A mutation in subunit B of the DNA polymerase α-primase complex from Novikoff hepatoma cells concomitant with a conformational change and abnormal catalytic properties of the DNA polymerase α-primase complex

Mutated constituents of the DNA replication complex might contribute to the mutational load of the genome during tumor development by impairing DNA synthesis as well as cell cycle–related control of DNA replication. To prove or disprove this hypothesis, we looked for mutations in the cDNA sequences...

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