Beyond knockout: a novel homodimerization-targeting MyD88 inhibitor prevents and cures type 1 diabetes in NOD mice

Abstract Introduction and Aims Studies have reported that myeloid differentiation factor 88 (MyD88) plays an important role in the development of Type 1 diabetes (T1D). The aim of this study was to determine the effects of the self-created MyD88 inhibitor, TJ-M2010–6, in preventing and treating T1D....

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Veröffentlicht in:	Metabolism, clinical and experimental clinical and experimental, 2016-09, Vol.65 (9), p.1267-1277
Hauptverfasser:	Zhang, Xue, Xing, Shuai, Li, Mingqiang, Zhang, Limin, Xie, Lin, He, Wentao, Liu, Jianhua, Chang, Sheng, Jiang, Fengchao, Zhou, Ping
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acids - drug effects Animals Blood Glucose - metabolism Cytokines - biosynthesis Dendritic Cells - drug effects Dendritic Cells - metabolism Diabetes Mellitus, Type 1 - drug therapy Diabetes Mellitus, Type 1 - pathology Diabetes Mellitus, Type 1 - prevention & control Endocrinology & Metabolism Female Hypoglycemic Agents - therapeutic use Immunity, Innate - drug effects Lymphocyte Activation - drug effects Mice Mice, Inbred NOD Mice, Knockout Models, Molecular Molecular Docking Simulation MyD88 MyD88 inhibitor Myeloid Differentiation Factor 88 - antagonists & inhibitors Myeloid Differentiation Factor 88 - genetics Pancreas - pathology Piperazines - therapeutic use T-Lymphocytes - drug effects T-Lymphocytes - immunology Therapeutics Thiazoles - therapeutic use Type 1 diabetes
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