Modeling Physical Stability of Amorphous Solids Based on Temperature and Moisture Stresses

Isothermal microcalorimetry was utilized to monitor the crystallization process of amorphous ritonavir (RTV) and its hydroxypropylmethylcellulose acetate succinate–based amorphous solid dispersion under various stressed conditions. An empirical model was developed: ln(τ)=ln(A)+EaRT−b⋅wc, where τ is...

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