Targeting ceramide metabolism in obesity

Obesity is a major health concern that increases the risk for insulin resistance, type 2 diabetes (T2D), and cardiovascular disease. Thus, an enormous research effort has been invested into understanding how obesity-associated dyslipidemia and obesity-induced alterations in lipid metabolism increase...

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Veröffentlicht in:	American journal of physiology: endocrinology and metabolism 2016-08, Vol.311 (2), p.E423-E435
Hauptverfasser:	Aburasayn, Hanin, Al Batran, Rami, Ussher, John R
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Atherosclerosis - metabolism Cardiovascular Diseases - metabolism Ceramides - metabolism Diabetes Mellitus, Type 2 - metabolism Dyslipidemias - metabolism Fatty Acids, Monounsaturated - pharmacology Heart Failure - metabolism Humans Insulin Resistance Lipid Metabolism - drug effects Liver - metabolism Mitochondria - metabolism Molecular Targeted Therapy Muscle, Skeletal - metabolism Myocardium - metabolism Obesity - metabolism
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