Cryptotanshinone induces melanoma cancer cells apoptosis via ROS-mitochondrial apoptotic pathway and impairs cell migration and invasion

Abstract Melanoma is the most serious type of skin cancer because it is highly frequency of drug resistance and can spread earlier and more quickly than other skin cancers. The objective of this research was to investigate the anticancer effects of cryptotanshinone on human melanoma cells in vitro,...

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Veröffentlicht in:	Biomedicine & pharmacotherapy 2016-08, Vol.82, p.319-326
Hauptverfasser:	Ye, Tinghong, Zhu, Shirui, Zhu, Yongxia, Feng, Qiang, He, Bing, Xiong, Yiong, Zhao, Lifeng, Zhang, Yiwen, Yu, Luoting, Yang, Li
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis Apoptosis - drug effects Cell cycle Cell Line, Tumor Cell Movement - drug effects Cell Proliferation - drug effects Cell Shape - drug effects Cell Survival - drug effects Cryptotanshinone G2 Phase Cell Cycle Checkpoints - drug effects Humans Internal Medicine Medical Education Melanoma Melanoma - metabolism Melanoma - pathology Migration and invasion Mitochondria - drug effects Mitochondria - metabolism Neoplasm Invasiveness Phenanthrenes - chemistry Phenanthrenes - pharmacology Reactive Oxygen Species - metabolism Signal Transduction - drug effects Skin Neoplasms - metabolism Skin Neoplasms - pathology Tumor Stem Cell Assay
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