Targeting the interaction of Aurora kinases and SIRT1 mediated by Wnt signaling pathway in colorectal cancer: A critical review

Abstract The Aurora kinases belong to the family of serine/threonine kinase, a central regulator of mitosis and their expression increased during G2/M phase. It is classified into Aurora A, B and C, each has distinct roles in cellular processes, which includes regulation of spindle assembly, functio...

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Veröffentlicht in:	Biomedicine & pharmacotherapy 2016-08, Vol.82, p.413-424
Hauptverfasser:	Subramaniyan, Boopathi, Jagadeesan, Kaviya, Ramakrishnan, Sabitha, Mathan, Ganeshan
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic Agents - pharmacology Antineoplastic Agents - therapeutic use Aurora kinases Aurora Kinases - metabolism Colorectal Neoplasms - drug therapy Colorectal Neoplasms - metabolism Humans Internal Medicine Medical Education Protein Binding - drug effects SIRT1 Sirtuin 1 - metabolism Wnt Signaling Pathway - drug effects Wnt signaling pathway and colorectal cancer
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