Umbilical cord-derived mesenchymal stem cells inhibit growth and promote apoptosis of HepG2 cells
Hepatocellular carcinoma is the fifth most common type of cancer worldwide and remains difficult to treat. The aim of this study was to investigate the effects of mesenchymal stem cells (MSCs) derived from the umbilical cord (UC-MSCs) on HepG2 hepatocellular carcinoma cells. UC-MSCs were co-cultured...
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| Veröffentlicht in: | Molecular medicine reports 2016-09, Vol.14 (3), p.2717-2724 |
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| creator | Tang, Ying-Mei Bao, Wei-Min Yang, Jin-Hui Ma, Lin-Kun Yang, Jing Xu, Ying Yang, Li-Hong Sha, Feng Xu, Zhi-Yuan Wu, Hua-Mei Zhou, Wei Li, Yan Li, Yu-Hua |
| description | Hepatocellular carcinoma is the fifth most common type of cancer worldwide and remains difficult to treat. The aim of this study was to investigate the effects of mesenchymal stem cells (MSCs) derived from the umbilical cord (UC-MSCs) on HepG2 hepatocellular carcinoma cells. UC-MSCs were co-cultured with HepG2 cells and biomarkers of UC-MSCs were analyzed by flow cytometry. mRNA and protein expression of genes were determined by reverse transcription-polymerase chain reaction and flow cytometry, respectively. Passage three and seven UC-MSCs expressed CD29, CD44, CD90 and CD105, whereas CD34 and CD45 were absent on these cells. Co-culture with UC-MSCs inhibited proliferation and promoted apoptosis of HepG2 cells in a time-dependent manner. The initial seeding density of UC-MSCs also influenced the proliferation and apoptosis of HepG2 cells, with an increased number of UC-MSCs causing enhanced proliferation inhibition and cell apoptosis. Co-culture with UC-MSCs downregulated mRNA and protein expression of α-fetoprotein (AFP), Bcl-2 and Survivin in HepG2 cells. Thus, UC-MSCs may inhibit growth and promote apoptosis of HepG2 cells through downregulation of AFP, Bcl-2 and Survivin. US-MSCs may be used as a novel therapy for treating hepatocellular carcinoma in the future. |
| doi_str_mv | 10.3892/mmr.2016.5537 |
| format | Article |
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The aim of this study was to investigate the effects of mesenchymal stem cells (MSCs) derived from the umbilical cord (UC-MSCs) on HepG2 hepatocellular carcinoma cells. UC-MSCs were co-cultured with HepG2 cells and biomarkers of UC-MSCs were analyzed by flow cytometry. mRNA and protein expression of genes were determined by reverse transcription-polymerase chain reaction and flow cytometry, respectively. Passage three and seven UC-MSCs expressed CD29, CD44, CD90 and CD105, whereas CD34 and CD45 were absent on these cells. Co-culture with UC-MSCs inhibited proliferation and promoted apoptosis of HepG2 cells in a time-dependent manner. The initial seeding density of UC-MSCs also influenced the proliferation and apoptosis of HepG2 cells, with an increased number of UC-MSCs causing enhanced proliferation inhibition and cell apoptosis. Co-culture with UC-MSCs downregulated mRNA and protein expression of α-fetoprotein (AFP), Bcl-2 and Survivin in HepG2 cells. Thus, UC-MSCs may inhibit growth and promote apoptosis of HepG2 cells through downregulation of AFP, Bcl-2 and Survivin. US-MSCs may be used as a novel therapy for treating hepatocellular carcinoma in the future.</description><identifier>ISSN: 1791-2997</identifier><identifier>EISSN: 1791-3004</identifier><identifier>DOI: 10.3892/mmr.2016.5537</identifier><identifier>PMID: 27485485</identifier><language>eng</language><publisher>Greece: D.A. Spandidos</publisher><subject>Antigens, Surface - metabolism ; Apoptosis ; Bcl-2 protein ; Biomarkers ; Biomarkers, Tumor ; Breast cancer ; Care and treatment ; CD105 antigen ; CD29 antigen ; CD34 antigen ; CD44 antigen ; CD45 antigen ; CD90 antigen ; Cell culture ; Cell Differentiation ; Cell growth ; Cell Proliferation ; co-culture ; Coculture Techniques ; Cytokines ; Flow cytometry ; Gene expression ; Gene Expression Regulation, Neoplastic ; Growth factors ; Health aspects ; Hep G2 Cells ; Hepatocellular carcinoma ; Hepatoma ; HepG2 cells ; Humans ; Immunoglobulins ; Immunophenotyping ; Liver cancer ; Mesenchymal stem cells ; Mesenchymal Stromal Cells - cytology ; Mesenchymal Stromal Cells - metabolism ; Mesenchyme ; Metastasis ; Polymerase chain reaction ; proliferation ; Reverse transcription ; RNA, Messenger - genetics ; RNA, Messenger - metabolism ; Stem cells ; Studies ; Survivin ; Umbilical cord ; Umbilical Cord - cytology ; umbilical cord-derived mesenchymal stem cells</subject><ispartof>Molecular medicine reports, 2016-09, Vol.14 (3), p.2717-2724</ispartof><rights>Copyright © 2016, Spandidos Publications</rights><rights>COPYRIGHT 2016 Spandidos Publications</rights><rights>Copyright Spandidos Publications UK Ltd. 2016</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c459t-6629cd981ffd034dc1593cb9a6dc9e080c5707474f8dd4ffb285a273c531ccd3</citedby><cites>FETCH-LOGICAL-c459t-6629cd981ffd034dc1593cb9a6dc9e080c5707474f8dd4ffb285a273c531ccd3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,5556,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27485485$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tang, Ying-Mei</creatorcontrib><creatorcontrib>Bao, Wei-Min</creatorcontrib><creatorcontrib>Yang, Jin-Hui</creatorcontrib><creatorcontrib>Ma, Lin-Kun</creatorcontrib><creatorcontrib>Yang, Jing</creatorcontrib><creatorcontrib>Xu, Ying</creatorcontrib><creatorcontrib>Yang, Li-Hong</creatorcontrib><creatorcontrib>Sha, Feng</creatorcontrib><creatorcontrib>Xu, Zhi-Yuan</creatorcontrib><creatorcontrib>Wu, Hua-Mei</creatorcontrib><creatorcontrib>Zhou, Wei</creatorcontrib><creatorcontrib>Li, Yan</creatorcontrib><creatorcontrib>Li, Yu-Hua</creatorcontrib><title>Umbilical cord-derived mesenchymal stem cells inhibit growth and promote apoptosis of HepG2 cells</title><title>Molecular medicine reports</title><addtitle>Mol Med Rep</addtitle><description>Hepatocellular carcinoma is the fifth most common type of cancer worldwide and remains difficult to treat. The aim of this study was to investigate the effects of mesenchymal stem cells (MSCs) derived from the umbilical cord (UC-MSCs) on HepG2 hepatocellular carcinoma cells. UC-MSCs were co-cultured with HepG2 cells and biomarkers of UC-MSCs were analyzed by flow cytometry. mRNA and protein expression of genes were determined by reverse transcription-polymerase chain reaction and flow cytometry, respectively. Passage three and seven UC-MSCs expressed CD29, CD44, CD90 and CD105, whereas CD34 and CD45 were absent on these cells. Co-culture with UC-MSCs inhibited proliferation and promoted apoptosis of HepG2 cells in a time-dependent manner. The initial seeding density of UC-MSCs also influenced the proliferation and apoptosis of HepG2 cells, with an increased number of UC-MSCs causing enhanced proliferation inhibition and cell apoptosis. Co-culture with UC-MSCs downregulated mRNA and protein expression of α-fetoprotein (AFP), Bcl-2 and Survivin in HepG2 cells. Thus, UC-MSCs may inhibit growth and promote apoptosis of HepG2 cells through downregulation of AFP, Bcl-2 and Survivin. US-MSCs may be used as a novel therapy for treating hepatocellular carcinoma in the future.</description><subject>Antigens, Surface - metabolism</subject><subject>Apoptosis</subject><subject>Bcl-2 protein</subject><subject>Biomarkers</subject><subject>Biomarkers, Tumor</subject><subject>Breast cancer</subject><subject>Care and treatment</subject><subject>CD105 antigen</subject><subject>CD29 antigen</subject><subject>CD34 antigen</subject><subject>CD44 antigen</subject><subject>CD45 antigen</subject><subject>CD90 antigen</subject><subject>Cell culture</subject><subject>Cell Differentiation</subject><subject>Cell growth</subject><subject>Cell Proliferation</subject><subject>co-culture</subject><subject>Coculture Techniques</subject><subject>Cytokines</subject><subject>Flow cytometry</subject><subject>Gene expression</subject><subject>Gene Expression Regulation, Neoplastic</subject><subject>Growth factors</subject><subject>Health aspects</subject><subject>Hep G2 Cells</subject><subject>Hepatocellular carcinoma</subject><subject>Hepatoma</subject><subject>HepG2 cells</subject><subject>Humans</subject><subject>Immunoglobulins</subject><subject>Immunophenotyping</subject><subject>Liver cancer</subject><subject>Mesenchymal stem cells</subject><subject>Mesenchymal Stromal Cells - cytology</subject><subject>Mesenchymal Stromal Cells - metabolism</subject><subject>Mesenchyme</subject><subject>Metastasis</subject><subject>Polymerase chain reaction</subject><subject>proliferation</subject><subject>Reverse transcription</subject><subject>RNA, Messenger - genetics</subject><subject>RNA, Messenger - metabolism</subject><subject>Stem cells</subject><subject>Studies</subject><subject>Survivin</subject><subject>Umbilical cord</subject><subject>Umbilical Cord - cytology</subject><subject>umbilical cord-derived mesenchymal stem cells</subject><issn>1791-2997</issn><issn>1791-3004</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNptkc1rHCEchofS0qRpj70WoYfk4tbPUY8hNEkhkEt6FsePrGEcpzrbkP--DrtJaQkKij6_lxeervuM0YZKRb6lVDYE4X7DORVvumMsFIYUIfb2cCdKiaPuQ60PCPWccPW-OyKCSd72cWd-piGO0ZoR2FwcdL7E396B5Kuf7PYptY-6-ASsH8cK4rSNQ1zAfcmPyxaYyYG55JQXD8yc5yXXWEEO4NrPV2Q_87F7F8xY_afDedLdXX6_u7iGN7dXPy7Ob6BlXC2w74myTkkcgkOUOYu5onZQpndWeSSR5QIJJliQzrEQBiK5IYJaTrG1jp50Z_vY1ufXztdFp1jXAmbyeVc1lhhRzoQkDf36H_qQd2Vq5TRWlDQGEfmXujej13EKeSnGrqH6nLWyknDCGrV5hWrL-RRtnnyI7f2fAbgfsCXXWnzQc4nJlCeNkV6N6mZUr0b1arTxXw5ld0Py7oV-VtiA0z1Q56YjulxfmJYEMYOIQiKwoH8A31en3w</recordid><startdate>20160901</startdate><enddate>20160901</enddate><creator>Tang, Ying-Mei</creator><creator>Bao, Wei-Min</creator><creator>Yang, Jin-Hui</creator><creator>Ma, Lin-Kun</creator><creator>Yang, Jing</creator><creator>Xu, Ying</creator><creator>Yang, Li-Hong</creator><creator>Sha, Feng</creator><creator>Xu, Zhi-Yuan</creator><creator>Wu, Hua-Mei</creator><creator>Zhou, Wei</creator><creator>Li, Yan</creator><creator>Li, Yu-Hua</creator><general>D.A. Spandidos</general><general>Spandidos Publications</general><general>Spandidos Publications UK Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AN0</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20160901</creationdate><title>Umbilical cord-derived mesenchymal stem cells inhibit growth and promote apoptosis of HepG2 cells</title><author>Tang, Ying-Mei ; Bao, Wei-Min ; Yang, Jin-Hui ; Ma, Lin-Kun ; Yang, Jing ; Xu, Ying ; Yang, Li-Hong ; Sha, Feng ; Xu, Zhi-Yuan ; Wu, Hua-Mei ; Zhou, Wei ; Li, Yan ; Li, Yu-Hua</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c459t-6629cd981ffd034dc1593cb9a6dc9e080c5707474f8dd4ffb285a273c531ccd3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Antigens, Surface - 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cytology</topic><topic>Mesenchymal Stromal Cells - metabolism</topic><topic>Mesenchyme</topic><topic>Metastasis</topic><topic>Polymerase chain reaction</topic><topic>proliferation</topic><topic>Reverse transcription</topic><topic>RNA, Messenger - genetics</topic><topic>RNA, Messenger - metabolism</topic><topic>Stem cells</topic><topic>Studies</topic><topic>Survivin</topic><topic>Umbilical cord</topic><topic>Umbilical Cord - cytology</topic><topic>umbilical cord-derived mesenchymal stem cells</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tang, Ying-Mei</creatorcontrib><creatorcontrib>Bao, Wei-Min</creatorcontrib><creatorcontrib>Yang, Jin-Hui</creatorcontrib><creatorcontrib>Ma, Lin-Kun</creatorcontrib><creatorcontrib>Yang, Jing</creatorcontrib><creatorcontrib>Xu, Ying</creatorcontrib><creatorcontrib>Yang, Li-Hong</creatorcontrib><creatorcontrib>Sha, Feng</creatorcontrib><creatorcontrib>Xu, Zhi-Yuan</creatorcontrib><creatorcontrib>Wu, Hua-Mei</creatorcontrib><creatorcontrib>Zhou, Wei</creatorcontrib><creatorcontrib>Li, Yan</creatorcontrib><creatorcontrib>Li, Yu-Hua</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>British Nursing Database</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Molecular medicine reports</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tang, Ying-Mei</au><au>Bao, Wei-Min</au><au>Yang, Jin-Hui</au><au>Ma, Lin-Kun</au><au>Yang, Jing</au><au>Xu, Ying</au><au>Yang, Li-Hong</au><au>Sha, Feng</au><au>Xu, Zhi-Yuan</au><au>Wu, Hua-Mei</au><au>Zhou, Wei</au><au>Li, Yan</au><au>Li, Yu-Hua</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Umbilical cord-derived mesenchymal stem cells inhibit growth and promote apoptosis of HepG2 cells</atitle><jtitle>Molecular medicine reports</jtitle><addtitle>Mol Med Rep</addtitle><date>2016-09-01</date><risdate>2016</risdate><volume>14</volume><issue>3</issue><spage>2717</spage><epage>2724</epage><pages>2717-2724</pages><issn>1791-2997</issn><eissn>1791-3004</eissn><abstract>Hepatocellular carcinoma is the fifth most common type of cancer worldwide and remains difficult to treat. The aim of this study was to investigate the effects of mesenchymal stem cells (MSCs) derived from the umbilical cord (UC-MSCs) on HepG2 hepatocellular carcinoma cells. UC-MSCs were co-cultured with HepG2 cells and biomarkers of UC-MSCs were analyzed by flow cytometry. mRNA and protein expression of genes were determined by reverse transcription-polymerase chain reaction and flow cytometry, respectively. Passage three and seven UC-MSCs expressed CD29, CD44, CD90 and CD105, whereas CD34 and CD45 were absent on these cells. Co-culture with UC-MSCs inhibited proliferation and promoted apoptosis of HepG2 cells in a time-dependent manner. The initial seeding density of UC-MSCs also influenced the proliferation and apoptosis of HepG2 cells, with an increased number of UC-MSCs causing enhanced proliferation inhibition and cell apoptosis. Co-culture with UC-MSCs downregulated mRNA and protein expression of α-fetoprotein (AFP), Bcl-2 and Survivin in HepG2 cells. Thus, UC-MSCs may inhibit growth and promote apoptosis of HepG2 cells through downregulation of AFP, Bcl-2 and Survivin. US-MSCs may be used as a novel therapy for treating hepatocellular carcinoma in the future.</abstract><cop>Greece</cop><pub>D.A. Spandidos</pub><pmid>27485485</pmid><doi>10.3892/mmr.2016.5537</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Molecular medicine reports, 2016-09, Vol.14 (3), p.2717-2724 |
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| source | Spandidos Publications Journals; MEDLINE; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Antigens, Surface - metabolism Apoptosis Bcl-2 protein Biomarkers Biomarkers, Tumor Breast cancer Care and treatment CD105 antigen CD29 antigen CD34 antigen CD44 antigen CD45 antigen CD90 antigen Cell culture Cell Differentiation Cell growth Cell Proliferation co-culture Coculture Techniques Cytokines Flow cytometry Gene expression Gene Expression Regulation, Neoplastic Growth factors Health aspects Hep G2 Cells Hepatocellular carcinoma Hepatoma HepG2 cells Humans Immunoglobulins Immunophenotyping Liver cancer Mesenchymal stem cells Mesenchymal Stromal Cells - cytology Mesenchymal Stromal Cells - metabolism Mesenchyme Metastasis Polymerase chain reaction proliferation Reverse transcription RNA, Messenger - genetics RNA, Messenger - metabolism Stem cells Studies Survivin Umbilical cord Umbilical Cord - cytology umbilical cord-derived mesenchymal stem cells |
| title | Umbilical cord-derived mesenchymal stem cells inhibit growth and promote apoptosis of HepG2 cells |
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