Bipolar disorder course, impaired glucose metabolism and antioxidant enzymes activities: A preliminary report
Abstract This study aimed to examine the role of oxidative stress in bipolar disorder (BD) by evaluating the relationship among antioxidant enzymes activities, impaired glucose metabolism (IGM) and illness course. We measured the activities of plasma superoxide dismutase (SOD) and glutathione peroxi...
Gespeichert in:
| Veröffentlicht in: | Journal of psychiatric research 2016-09, Vol.80, p.38-44 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 44 |
|---|---|
| container_issue | |
| container_start_page | 38 |
| container_title | Journal of psychiatric research |
| container_volume | 80 |
| creator | Mansur, Rodrigo B Rizzo, Lucas B Santos, Camila M Asevedo, Elson Cunha, Graccielle R Noto, Mariane N Pedrini, Mariana Zeni-Graiff, Maiara Gouvea, Eduardo S Cordeiro, Quirino Reininghaus, Eva Z McIntyre, Roger S Brietzke, Elisa |
| description | Abstract This study aimed to examine the role of oxidative stress in bipolar disorder (BD) by evaluating the relationship among antioxidant enzymes activities, impaired glucose metabolism (IGM) and illness course. We measured the activities of plasma superoxide dismutase (SOD) and glutathione peroxidase (GPx) in individuals with BD (N = 55) and healthy controls (N = 28). Information related to current and past psychiatric/medical history, as well as prescription of any pharmacological treatments was captured. Impaired glucose metabolism was operationalized as pre-diabetes or type 2 diabetes mellitus. Our results showed that, after adjustment for age, gender, alcohol use, smoking and current medication, both BD (p |
| doi_str_mv | 10.1016/j.jpsychires.2016.05.014 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1810354291</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>1_s2_0_S0022395616301054</els_id><sourcerecordid>1810354291</sourcerecordid><originalsourceid>FETCH-LOGICAL-c429t-fd0483215f96c7b0b6f23d81f9c1745bdbaeda814fd42a95ba8aedfe104574f53</originalsourceid><addsrcrecordid>eNqNkU9v1DAQxS0EotvCV0A-ciDB49j5wwGpraAgVeIAnC3HnoCXJA6epGL59Hi1BSROHKyRRm_ejH-PMQ6iBAH1y325X-jgvoaEVMrcKYUuBagHbAdt0xVQNd1DthNCyqLqdH3Gzon2QohGgnrMzmQjW5A17Nh0FZY42sR9oJg8Ju7ilghf8DAtNvt7_mXcXCTkE662j2OgidvZ57eG-CP4XDnOPw8TErduDXdhDUiv-CVfEo5hCrNNB55wiWl9wh4NdiR8el8v2Oe3bz5dvytuP9y8v768LZyS3VoMXqi2kqCHrnZNL_p6kJVvYegcNEr3vrfobQtq8EraTve2zY0BQSjdqEFXF-z5yXdJ8fuGtJopkMNxtDPGjQy0ICqdd0GWtiepS5Eo4WCWFKZ8sgFhjrDN3vyFbY6wjdAmw86jz-63bP2E_s_gb7pZcHUSYP7rXcBkyAWcHfrs5VbjY_ifLa__MXFjmIOz4zc8IO1zXHNmacCQNMJ8PIZ-zBzqSoDQqvoFu1etqw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1810354291</pqid></control><display><type>article</type><title>Bipolar disorder course, impaired glucose metabolism and antioxidant enzymes activities: A preliminary report</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><creator>Mansur, Rodrigo B ; Rizzo, Lucas B ; Santos, Camila M ; Asevedo, Elson ; Cunha, Graccielle R ; Noto, Mariane N ; Pedrini, Mariana ; Zeni-Graiff, Maiara ; Gouvea, Eduardo S ; Cordeiro, Quirino ; Reininghaus, Eva Z ; McIntyre, Roger S ; Brietzke, Elisa</creator><creatorcontrib>Mansur, Rodrigo B ; Rizzo, Lucas B ; Santos, Camila M ; Asevedo, Elson ; Cunha, Graccielle R ; Noto, Mariane N ; Pedrini, Mariana ; Zeni-Graiff, Maiara ; Gouvea, Eduardo S ; Cordeiro, Quirino ; Reininghaus, Eva Z ; McIntyre, Roger S ; Brietzke, Elisa</creatorcontrib><description>Abstract This study aimed to examine the role of oxidative stress in bipolar disorder (BD) by evaluating the relationship among antioxidant enzymes activities, impaired glucose metabolism (IGM) and illness course. We measured the activities of plasma superoxide dismutase (SOD) and glutathione peroxidase (GPx) in individuals with BD (N = 55) and healthy controls (N = 28). Information related to current and past psychiatric/medical history, as well as prescription of any pharmacological treatments was captured. Impaired glucose metabolism was operationalized as pre-diabetes or type 2 diabetes mellitus. Our results showed that, after adjustment for age, gender, alcohol use, smoking and current medication, both BD (p < 0.001) and IGM (p = 0.019) were associated with increased GPx activity, whereas only BD was associated with decreased SOD activity (p = 0.008). We also observed an interaction between BD and IGM on SOD activity (p = 0.017), whereas the difference between BD and controls was only significant in individuals with IGM (p = 0.009). IGM, GPx and SOD activity were independently associated with variables of illness course. Moreover, IGM moderated the association between SOD activity and number of mood episodes (p < 0.001), as a positive correlation between SOD activity and mood episodes was observed only in participants with IGM. In conclusion, BD and IGM are associated with independent and synergistic effects on markers of oxidative stress. The foregoing observations suggest that the heterogeneity observed in previous studies evaluating antioxidant enzymes in BD may be a function of concurrent IGM; and that imbalances in the oxidative system may subserve the association between BD and IGM, as well as its relationship with illness course.</description><identifier>ISSN: 0022-3956</identifier><identifier>EISSN: 1879-1379</identifier><identifier>DOI: 10.1016/j.jpsychires.2016.05.014</identifier><identifier>PMID: 27281261</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Adult ; bipolar disorder ; Bipolar Disorder - blood ; Bipolar Disorder - complications ; Body Mass Index ; Comorbidity ; Diabetes mellitus ; Diabetes Mellitus, Type 2 - blood ; Diabetes Mellitus, Type 2 - complications ; Female ; Glucose - metabolism ; Glutathione Peroxidase - blood ; Humans ; Impaired glucose metabolism ; Male ; Middle Aged ; Oxidative stress ; Psychiatric Status Rating Scales ; Psychiatry ; Statistics as Topic ; Superoxide Dismutase - blood</subject><ispartof>Journal of psychiatric research, 2016-09, Vol.80, p.38-44</ispartof><rights>2016 Elsevier Ltd</rights><rights>Copyright © 2016 Elsevier Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c429t-fd0483215f96c7b0b6f23d81f9c1745bdbaeda814fd42a95ba8aedfe104574f53</citedby><cites>FETCH-LOGICAL-c429t-fd0483215f96c7b0b6f23d81f9c1745bdbaeda814fd42a95ba8aedfe104574f53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0022395616301054$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27281261$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mansur, Rodrigo B</creatorcontrib><creatorcontrib>Rizzo, Lucas B</creatorcontrib><creatorcontrib>Santos, Camila M</creatorcontrib><creatorcontrib>Asevedo, Elson</creatorcontrib><creatorcontrib>Cunha, Graccielle R</creatorcontrib><creatorcontrib>Noto, Mariane N</creatorcontrib><creatorcontrib>Pedrini, Mariana</creatorcontrib><creatorcontrib>Zeni-Graiff, Maiara</creatorcontrib><creatorcontrib>Gouvea, Eduardo S</creatorcontrib><creatorcontrib>Cordeiro, Quirino</creatorcontrib><creatorcontrib>Reininghaus, Eva Z</creatorcontrib><creatorcontrib>McIntyre, Roger S</creatorcontrib><creatorcontrib>Brietzke, Elisa</creatorcontrib><title>Bipolar disorder course, impaired glucose metabolism and antioxidant enzymes activities: A preliminary report</title><title>Journal of psychiatric research</title><addtitle>J Psychiatr Res</addtitle><description>Abstract This study aimed to examine the role of oxidative stress in bipolar disorder (BD) by evaluating the relationship among antioxidant enzymes activities, impaired glucose metabolism (IGM) and illness course. We measured the activities of plasma superoxide dismutase (SOD) and glutathione peroxidase (GPx) in individuals with BD (N = 55) and healthy controls (N = 28). Information related to current and past psychiatric/medical history, as well as prescription of any pharmacological treatments was captured. Impaired glucose metabolism was operationalized as pre-diabetes or type 2 diabetes mellitus. Our results showed that, after adjustment for age, gender, alcohol use, smoking and current medication, both BD (p < 0.001) and IGM (p = 0.019) were associated with increased GPx activity, whereas only BD was associated with decreased SOD activity (p = 0.008). We also observed an interaction between BD and IGM on SOD activity (p = 0.017), whereas the difference between BD and controls was only significant in individuals with IGM (p = 0.009). IGM, GPx and SOD activity were independently associated with variables of illness course. Moreover, IGM moderated the association between SOD activity and number of mood episodes (p < 0.001), as a positive correlation between SOD activity and mood episodes was observed only in participants with IGM. In conclusion, BD and IGM are associated with independent and synergistic effects on markers of oxidative stress. The foregoing observations suggest that the heterogeneity observed in previous studies evaluating antioxidant enzymes in BD may be a function of concurrent IGM; and that imbalances in the oxidative system may subserve the association between BD and IGM, as well as its relationship with illness course.</description><subject>Adult</subject><subject>bipolar disorder</subject><subject>Bipolar Disorder - blood</subject><subject>Bipolar Disorder - complications</subject><subject>Body Mass Index</subject><subject>Comorbidity</subject><subject>Diabetes mellitus</subject><subject>Diabetes Mellitus, Type 2 - blood</subject><subject>Diabetes Mellitus, Type 2 - complications</subject><subject>Female</subject><subject>Glucose - metabolism</subject><subject>Glutathione Peroxidase - blood</subject><subject>Humans</subject><subject>Impaired glucose metabolism</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Oxidative stress</subject><subject>Psychiatric Status Rating Scales</subject><subject>Psychiatry</subject><subject>Statistics as Topic</subject><subject>Superoxide Dismutase - blood</subject><issn>0022-3956</issn><issn>1879-1379</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkU9v1DAQxS0EotvCV0A-ciDB49j5wwGpraAgVeIAnC3HnoCXJA6epGL59Hi1BSROHKyRRm_ejH-PMQ6iBAH1y325X-jgvoaEVMrcKYUuBagHbAdt0xVQNd1DthNCyqLqdH3Gzon2QohGgnrMzmQjW5A17Nh0FZY42sR9oJg8Ju7ilghf8DAtNvt7_mXcXCTkE662j2OgidvZ57eG-CP4XDnOPw8TErduDXdhDUiv-CVfEo5hCrNNB55wiWl9wh4NdiR8el8v2Oe3bz5dvytuP9y8v768LZyS3VoMXqi2kqCHrnZNL_p6kJVvYegcNEr3vrfobQtq8EraTve2zY0BQSjdqEFXF-z5yXdJ8fuGtJopkMNxtDPGjQy0ICqdd0GWtiepS5Eo4WCWFKZ8sgFhjrDN3vyFbY6wjdAmw86jz-63bP2E_s_gb7pZcHUSYP7rXcBkyAWcHfrs5VbjY_ifLa__MXFjmIOz4zc8IO1zXHNmacCQNMJ8PIZ-zBzqSoDQqvoFu1etqw</recordid><startdate>20160901</startdate><enddate>20160901</enddate><creator>Mansur, Rodrigo B</creator><creator>Rizzo, Lucas B</creator><creator>Santos, Camila M</creator><creator>Asevedo, Elson</creator><creator>Cunha, Graccielle R</creator><creator>Noto, Mariane N</creator><creator>Pedrini, Mariana</creator><creator>Zeni-Graiff, Maiara</creator><creator>Gouvea, Eduardo S</creator><creator>Cordeiro, Quirino</creator><creator>Reininghaus, Eva Z</creator><creator>McIntyre, Roger S</creator><creator>Brietzke, Elisa</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20160901</creationdate><title>Bipolar disorder course, impaired glucose metabolism and antioxidant enzymes activities: A preliminary report</title><author>Mansur, Rodrigo B ; Rizzo, Lucas B ; Santos, Camila M ; Asevedo, Elson ; Cunha, Graccielle R ; Noto, Mariane N ; Pedrini, Mariana ; Zeni-Graiff, Maiara ; Gouvea, Eduardo S ; Cordeiro, Quirino ; Reininghaus, Eva Z ; McIntyre, Roger S ; Brietzke, Elisa</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c429t-fd0483215f96c7b0b6f23d81f9c1745bdbaeda814fd42a95ba8aedfe104574f53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Adult</topic><topic>bipolar disorder</topic><topic>Bipolar Disorder - blood</topic><topic>Bipolar Disorder - complications</topic><topic>Body Mass Index</topic><topic>Comorbidity</topic><topic>Diabetes mellitus</topic><topic>Diabetes Mellitus, Type 2 - blood</topic><topic>Diabetes Mellitus, Type 2 - complications</topic><topic>Female</topic><topic>Glucose - metabolism</topic><topic>Glutathione Peroxidase - blood</topic><topic>Humans</topic><topic>Impaired glucose metabolism</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Oxidative stress</topic><topic>Psychiatric Status Rating Scales</topic><topic>Psychiatry</topic><topic>Statistics as Topic</topic><topic>Superoxide Dismutase - blood</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mansur, Rodrigo B</creatorcontrib><creatorcontrib>Rizzo, Lucas B</creatorcontrib><creatorcontrib>Santos, Camila M</creatorcontrib><creatorcontrib>Asevedo, Elson</creatorcontrib><creatorcontrib>Cunha, Graccielle R</creatorcontrib><creatorcontrib>Noto, Mariane N</creatorcontrib><creatorcontrib>Pedrini, Mariana</creatorcontrib><creatorcontrib>Zeni-Graiff, Maiara</creatorcontrib><creatorcontrib>Gouvea, Eduardo S</creatorcontrib><creatorcontrib>Cordeiro, Quirino</creatorcontrib><creatorcontrib>Reininghaus, Eva Z</creatorcontrib><creatorcontrib>McIntyre, Roger S</creatorcontrib><creatorcontrib>Brietzke, Elisa</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of psychiatric research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mansur, Rodrigo B</au><au>Rizzo, Lucas B</au><au>Santos, Camila M</au><au>Asevedo, Elson</au><au>Cunha, Graccielle R</au><au>Noto, Mariane N</au><au>Pedrini, Mariana</au><au>Zeni-Graiff, Maiara</au><au>Gouvea, Eduardo S</au><au>Cordeiro, Quirino</au><au>Reininghaus, Eva Z</au><au>McIntyre, Roger S</au><au>Brietzke, Elisa</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Bipolar disorder course, impaired glucose metabolism and antioxidant enzymes activities: A preliminary report</atitle><jtitle>Journal of psychiatric research</jtitle><addtitle>J Psychiatr Res</addtitle><date>2016-09-01</date><risdate>2016</risdate><volume>80</volume><spage>38</spage><epage>44</epage><pages>38-44</pages><issn>0022-3956</issn><eissn>1879-1379</eissn><abstract>Abstract This study aimed to examine the role of oxidative stress in bipolar disorder (BD) by evaluating the relationship among antioxidant enzymes activities, impaired glucose metabolism (IGM) and illness course. We measured the activities of plasma superoxide dismutase (SOD) and glutathione peroxidase (GPx) in individuals with BD (N = 55) and healthy controls (N = 28). Information related to current and past psychiatric/medical history, as well as prescription of any pharmacological treatments was captured. Impaired glucose metabolism was operationalized as pre-diabetes or type 2 diabetes mellitus. Our results showed that, after adjustment for age, gender, alcohol use, smoking and current medication, both BD (p < 0.001) and IGM (p = 0.019) were associated with increased GPx activity, whereas only BD was associated with decreased SOD activity (p = 0.008). We also observed an interaction between BD and IGM on SOD activity (p = 0.017), whereas the difference between BD and controls was only significant in individuals with IGM (p = 0.009). IGM, GPx and SOD activity were independently associated with variables of illness course. Moreover, IGM moderated the association between SOD activity and number of mood episodes (p < 0.001), as a positive correlation between SOD activity and mood episodes was observed only in participants with IGM. In conclusion, BD and IGM are associated with independent and synergistic effects on markers of oxidative stress. The foregoing observations suggest that the heterogeneity observed in previous studies evaluating antioxidant enzymes in BD may be a function of concurrent IGM; and that imbalances in the oxidative system may subserve the association between BD and IGM, as well as its relationship with illness course.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>27281261</pmid><doi>10.1016/j.jpsychires.2016.05.014</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0022-3956 |
| ispartof | Journal of psychiatric research, 2016-09, Vol.80, p.38-44 |
| issn | 0022-3956 1879-1379 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1810354291 |
| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Adult bipolar disorder Bipolar Disorder - blood Bipolar Disorder - complications Body Mass Index Comorbidity Diabetes mellitus Diabetes Mellitus, Type 2 - blood Diabetes Mellitus, Type 2 - complications Female Glucose - metabolism Glutathione Peroxidase - blood Humans Impaired glucose metabolism Male Middle Aged Oxidative stress Psychiatric Status Rating Scales Psychiatry Statistics as Topic Superoxide Dismutase - blood |
| title | Bipolar disorder course, impaired glucose metabolism and antioxidant enzymes activities: A preliminary report |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-05T09%3A30%3A50IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Bipolar%20disorder%20course,%20impaired%20glucose%20metabolism%20and%20antioxidant%20enzymes%20activities:%20A%20preliminary%20report&rft.jtitle=Journal%20of%20psychiatric%20research&rft.au=Mansur,%20Rodrigo%20B&rft.date=2016-09-01&rft.volume=80&rft.spage=38&rft.epage=44&rft.pages=38-44&rft.issn=0022-3956&rft.eissn=1879-1379&rft_id=info:doi/10.1016/j.jpsychires.2016.05.014&rft_dat=%3Cproquest_cross%3E1810354291%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1810354291&rft_id=info:pmid/27281261&rft_els_id=1_s2_0_S0022395616301054&rfr_iscdi=true |