Local Tolerance Testing under REACH: Accepted Non-animal Methods are Not on Equal Footing with Animal Tests

In general, no single non-animal method can cover the complexity of any given animal test. Therefore, fixed sets of in vitro (and in chemico) methods have been combined into testing strategies for skin and eye irritation and skin sensitisation testing, with pre-defined prediction models for substanc...

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Veröffentlicht in:	Alternatives to laboratory animals 2016-07, Vol.44 (3), p.281-299
Hauptverfasser:	Sauer, Ursula G., Hill, Erin H., Curren, Rodger D., Kolle, Susanne N., Teubner, Wera, Mehling, Annette, Landsiedel, Robert
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal Testing Alternatives Animals Dermatitis, Contact European Union Eye Diseases - chemically induced Eye Injuries - chemically induced Hazardous Substances - toxicity Legislation, Drug Skin Diseases - chemically induced Toxicity Tests - standards
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