Immunotoxin FN18-CRM9 induces stronger T cell signaling than unconjugated monoclonal antibody FN18

The T-cell receptor (TCR)/CD3 complex is the target of therapeutic strategies aimed at prolonging allograft survival. The immunotoxin FN18-CRM9, composed of the anti-CD3 monoclonal antibody FN18 and the mutated diphtheria toxin CRM9, is useful for prolonging allograft survival in preclinical models...

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Veröffentlicht in:	Transplantation 2001-08, Vol.72 (3), p.496-503
Hauptverfasser:	HAMAWY, Majed M, TSUCHIDA, Masahiro, CHO, Clifford S, MANTHEI, Eric R, FECHNER, John H, KNECHTLE, Stuart J
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Motifs - physiology Animals Antibodies, Monoclonal - genetics Antibodies, Monoclonal - metabolism Antibodies, Monoclonal - pharmacology Biological and medical sciences Biological Transport - drug effects CD3 Complex - drug effects CD3 Complex - metabolism Diphtheria Toxin - genetics Diphtheria Toxin - metabolism Diphtheria Toxin - pharmacology Down-Regulation Enzyme Inhibitors - pharmacology fluorescein isothiocyanate Fundamental and applied biological sciences. Psychology Fundamental immunology Genistein - pharmacology Immunotoxins - genetics Immunotoxins - metabolism Immunotoxins - pharmacology Macaca mulatta Male Phosphorylation - drug effects Recombinant Fusion Proteins - genetics Recombinant Fusion Proteins - metabolism Recombinant Fusion Proteins - pharmacology Signal Transduction - physiology T-Lymphocytes - drug effects T-Lymphocytes - physiology Tissue, organ and graft immunology toxin CRM9 tyrosine Tyrosine - metabolism
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