A DNA microarray screen for genes involved in c-MYC and N-MYC oncogenesis in human tumors

MYC proto-oncogenes play a major role in various types of human tumors. The products of these genes are transcription factors that bind to specific sequences and activate the expression of target genes. Identifying these target genes and their downstream effectors is a crucial step in understanding...

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Veröffentlicht in:	Oncogene 2001-08, Vol.20 (36), p.4984-4994
Hauptverfasser:	SCHULDINER, Oren, BENVENISTY, Nissim
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Binding sites Biological and medical sciences Brain Neoplasms - etiology Brain Neoplasms - metabolism c-MYC gene c-Myc protein Carcinogenesis Cell cycle Cell Cycle Proteins Cell physiology Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes DNA microarrays DNA-Binding Proteins E2F Transcription Factors E2F1 gene E2F1 Transcription Factor Fundamental and applied biological sciences. Psychology Gene Expression Profiling Gene Expression Regulation, Neoplastic Humans Lymphoma Lymphoma - etiology Lymphoma - metabolism Mice Molecular and cellular biology Myc protein N-MYC gene Neoplasms - etiology Neoplasms - metabolism Oligonucleotide Array Sequence Analysis - methods Promoter Regions, Genetic Proto-Oncogene Proteins c-myc - physiology Proto-oncogenes Rats Regulatory sequences Repressor Proteins - biosynthesis Repressor Proteins - genetics RNA, Neoplasm - biosynthesis Transcription factors Transcription Factors - biosynthesis Transcription Factors - genetics Transgenic mice TSC2 gene Tuberous Sclerosis Complex 2 Tumor cell lines Tumor Cells, Cultured Tumor Suppressor Proteins Tumorigenesis Tumors
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