Respiratory syncytial virus infections in autologous blood and marrow transplant recipients with breast cancer : combination therapy with aerosolized ribavirin and parenteral immunoglobulins
Scant data are available concerning the impact and response to therapy of respiratory syncytial virus (RSV) infections in patients undergoing autologous blood and marrow transplantation (BMT) for breast cancer. During eight winter seasons from 1992-1993 to 1999-2000, nine (4%) of 249 such patients w...
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| Veröffentlicht in: | Bone marrow transplantation (Basingstoke) 2001-08, Vol.28 (3), p.271-275 |
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| creator | GHOSH, S CHAMPLIN, R. E WHIMBEY, E UENO, N. T ANDERLINI, P ROLSTON, K RAAD, I KONTOYIANNIS, D JACOBSON, K LUNA, M TARRAND, J |
| description | Scant data are available concerning the impact and response to therapy of respiratory syncytial virus (RSV) infections in patients undergoing autologous blood and marrow transplantation (BMT) for breast cancer. During eight winter seasons from 1992-1993 to 1999-2000, nine (4%) of 249 such patients were hospitalized with RSV infections. Six patients, including all five patients who were early post transplant in the pre-engraftment period, developed pneumonia and were treated with a combination of aerosolized ribavirin and IVIG. Among five patients with pneumonia in whom therapy was initiated prior to respiratory failure, one (20%) died. The sixth patient, in whom therapy was initiated after respiratory failure developed, also died. In total, two (1%) patients, both of whom were in the pre-engraftment period, died of progressive pneumonia. In conclusion, RSV is a significant cause of life-threatening pneumonia in autologous BMT recipients with breast cancer during the early post-transplant period, and accounted for a substantial portion of the overall transplant-related mortality, which in recent years has been minimal. |
| doi_str_mv | 10.1038/sj.bmt.1703131 |
| format | Article |
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E ; WHIMBEY, E ; UENO, N. T ; ANDERLINI, P ; ROLSTON, K ; RAAD, I ; KONTOYIANNIS, D ; JACOBSON, K ; LUNA, M ; TARRAND, J</creator><creatorcontrib>GHOSH, S ; CHAMPLIN, R. E ; WHIMBEY, E ; UENO, N. T ; ANDERLINI, P ; ROLSTON, K ; RAAD, I ; KONTOYIANNIS, D ; JACOBSON, K ; LUNA, M ; TARRAND, J</creatorcontrib><description>Scant data are available concerning the impact and response to therapy of respiratory syncytial virus (RSV) infections in patients undergoing autologous blood and marrow transplantation (BMT) for breast cancer. During eight winter seasons from 1992-1993 to 1999-2000, nine (4%) of 249 such patients were hospitalized with RSV infections. Six patients, including all five patients who were early post transplant in the pre-engraftment period, developed pneumonia and were treated with a combination of aerosolized ribavirin and IVIG. Among five patients with pneumonia in whom therapy was initiated prior to respiratory failure, one (20%) died. The sixth patient, in whom therapy was initiated after respiratory failure developed, also died. In total, two (1%) patients, both of whom were in the pre-engraftment period, died of progressive pneumonia. In conclusion, RSV is a significant cause of life-threatening pneumonia in autologous BMT recipients with breast cancer during the early post-transplant period, and accounted for a substantial portion of the overall transplant-related mortality, which in recent years has been minimal.</description><identifier>ISSN: 0268-3369</identifier><identifier>EISSN: 1476-5365</identifier><identifier>DOI: 10.1038/sj.bmt.1703131</identifier><identifier>PMID: 11535995</identifier><identifier>CODEN: BMTRE9</identifier><language>eng</language><publisher>Basingstoke: Nature Publishing Group</publisher><subject>Aerosols ; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy ; Antibiotics. Antiinfectious agents. Antiparasitic agents ; Antineoplastic Combined Chemotherapy Protocols - administration & dosage ; Antineoplastic Combined Chemotherapy Protocols - toxicity ; Antiviral agents ; Antiviral Agents - administration & dosage ; Autografts ; Biological and medical sciences ; Blood ; Bone marrow ; Bone marrow transplantation ; Bone Marrow Transplantation - adverse effects ; Bone Marrow Transplantation - mortality ; Bone marrow, stem cells transplantation. Graft versus host reaction ; Breast cancer ; Breast Neoplasms - complications ; Breast Neoplasms - therapy ; Disease Progression ; Female ; Hematopoietic Stem Cell Transplantation - adverse effects ; Hematopoietic Stem Cell Transplantation - mortality ; Humans ; Immunoglobulins ; Immunoglobulins, Intravenous - administration & dosage ; Infections ; Intravenous administration ; Medical sciences ; Pharmacology. Drug treatments ; Pneumonia ; Pneumonia, Viral - chemically induced ; Pneumonia, Viral - drug therapy ; Pneumonia, Viral - mortality ; Respiratory failure ; Respiratory syncytial virus ; Respiratory Syncytial Virus Infections - chemically induced ; Respiratory Syncytial Virus Infections - drug therapy ; Respiratory Syncytial Virus Infections - mortality ; Retrospective Studies ; Ribavirin ; Ribavirin - administration & dosage ; Stem cell transplantation ; Survival Rate ; Therapy ; Transfusions. Complications. Transfusion reactions. Cell and gene therapy ; Transplantation ; Transplantation, Autologous - adverse effects ; Transplantation, Autologous - mortality ; Transplants & implants ; Viruses</subject><ispartof>Bone marrow transplantation (Basingstoke), 2001-08, Vol.28 (3), p.271-275</ispartof><rights>2002 INIST-CNRS</rights><rights>Copyright Nature Publishing Group Aug 2001</rights><rights>Macmillan Publishers Limited 2001.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c449t-3447234245616be084885ac90f9c843ac77a0c674953db9093f0eb88ba1e29fc3</citedby><cites>FETCH-LOGICAL-c449t-3447234245616be084885ac90f9c843ac77a0c674953db9093f0eb88ba1e29fc3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=14112239$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11535995$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>GHOSH, S</creatorcontrib><creatorcontrib>CHAMPLIN, R. E</creatorcontrib><creatorcontrib>WHIMBEY, E</creatorcontrib><creatorcontrib>UENO, N. T</creatorcontrib><creatorcontrib>ANDERLINI, P</creatorcontrib><creatorcontrib>ROLSTON, K</creatorcontrib><creatorcontrib>RAAD, I</creatorcontrib><creatorcontrib>KONTOYIANNIS, D</creatorcontrib><creatorcontrib>JACOBSON, K</creatorcontrib><creatorcontrib>LUNA, M</creatorcontrib><creatorcontrib>TARRAND, J</creatorcontrib><title>Respiratory syncytial virus infections in autologous blood and marrow transplant recipients with breast cancer : combination therapy with aerosolized ribavirin and parenteral immunoglobulins</title><title>Bone marrow transplantation (Basingstoke)</title><addtitle>Bone Marrow Transplant</addtitle><description>Scant data are available concerning the impact and response to therapy of respiratory syncytial virus (RSV) infections in patients undergoing autologous blood and marrow transplantation (BMT) for breast cancer. During eight winter seasons from 1992-1993 to 1999-2000, nine (4%) of 249 such patients were hospitalized with RSV infections. Six patients, including all five patients who were early post transplant in the pre-engraftment period, developed pneumonia and were treated with a combination of aerosolized ribavirin and IVIG. Among five patients with pneumonia in whom therapy was initiated prior to respiratory failure, one (20%) died. The sixth patient, in whom therapy was initiated after respiratory failure developed, also died. In total, two (1%) patients, both of whom were in the pre-engraftment period, died of progressive pneumonia. In conclusion, RSV is a significant cause of life-threatening pneumonia in autologous BMT recipients with breast cancer during the early post-transplant period, and accounted for a substantial portion of the overall transplant-related mortality, which in recent years has been minimal.</description><subject>Aerosols</subject><subject>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</subject><subject>Antibiotics. Antiinfectious agents. Antiparasitic agents</subject><subject>Antineoplastic Combined Chemotherapy Protocols - administration & dosage</subject><subject>Antineoplastic Combined Chemotherapy Protocols - toxicity</subject><subject>Antiviral agents</subject><subject>Antiviral Agents - administration & dosage</subject><subject>Autografts</subject><subject>Biological and medical sciences</subject><subject>Blood</subject><subject>Bone marrow</subject><subject>Bone marrow transplantation</subject><subject>Bone Marrow Transplantation - adverse effects</subject><subject>Bone Marrow Transplantation - mortality</subject><subject>Bone marrow, stem cells transplantation. Graft versus host reaction</subject><subject>Breast cancer</subject><subject>Breast Neoplasms - complications</subject><subject>Breast Neoplasms - therapy</subject><subject>Disease Progression</subject><subject>Female</subject><subject>Hematopoietic Stem Cell Transplantation - adverse effects</subject><subject>Hematopoietic Stem Cell Transplantation - mortality</subject><subject>Humans</subject><subject>Immunoglobulins</subject><subject>Immunoglobulins, Intravenous - administration & dosage</subject><subject>Infections</subject><subject>Intravenous administration</subject><subject>Medical sciences</subject><subject>Pharmacology. Drug treatments</subject><subject>Pneumonia</subject><subject>Pneumonia, Viral - chemically induced</subject><subject>Pneumonia, Viral - drug therapy</subject><subject>Pneumonia, Viral - mortality</subject><subject>Respiratory failure</subject><subject>Respiratory syncytial virus</subject><subject>Respiratory Syncytial Virus Infections - chemically induced</subject><subject>Respiratory Syncytial Virus Infections - drug therapy</subject><subject>Respiratory Syncytial Virus Infections - mortality</subject><subject>Retrospective Studies</subject><subject>Ribavirin</subject><subject>Ribavirin - administration & dosage</subject><subject>Stem cell transplantation</subject><subject>Survival Rate</subject><subject>Therapy</subject><subject>Transfusions. Complications. Transfusion reactions. 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E ; WHIMBEY, E ; UENO, N. T ; ANDERLINI, P ; ROLSTON, K ; RAAD, I ; KONTOYIANNIS, D ; JACOBSON, K ; LUNA, M ; TARRAND, J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c449t-3447234245616be084885ac90f9c843ac77a0c674953db9093f0eb88ba1e29fc3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Aerosols</topic><topic>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</topic><topic>Antibiotics. Antiinfectious agents. Antiparasitic agents</topic><topic>Antineoplastic Combined Chemotherapy Protocols - administration & dosage</topic><topic>Antineoplastic Combined Chemotherapy Protocols - toxicity</topic><topic>Antiviral agents</topic><topic>Antiviral Agents - administration & dosage</topic><topic>Autografts</topic><topic>Biological and medical sciences</topic><topic>Blood</topic><topic>Bone marrow</topic><topic>Bone marrow transplantation</topic><topic>Bone Marrow Transplantation - adverse effects</topic><topic>Bone Marrow Transplantation - mortality</topic><topic>Bone marrow, stem cells transplantation. 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E</au><au>WHIMBEY, E</au><au>UENO, N. T</au><au>ANDERLINI, P</au><au>ROLSTON, K</au><au>RAAD, I</au><au>KONTOYIANNIS, D</au><au>JACOBSON, K</au><au>LUNA, M</au><au>TARRAND, J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Respiratory syncytial virus infections in autologous blood and marrow transplant recipients with breast cancer : combination therapy with aerosolized ribavirin and parenteral immunoglobulins</atitle><jtitle>Bone marrow transplantation (Basingstoke)</jtitle><addtitle>Bone Marrow Transplant</addtitle><date>2001-08-01</date><risdate>2001</risdate><volume>28</volume><issue>3</issue><spage>271</spage><epage>275</epage><pages>271-275</pages><issn>0268-3369</issn><eissn>1476-5365</eissn><coden>BMTRE9</coden><abstract>Scant data are available concerning the impact and response to therapy of respiratory syncytial virus (RSV) infections in patients undergoing autologous blood and marrow transplantation (BMT) for breast cancer. During eight winter seasons from 1992-1993 to 1999-2000, nine (4%) of 249 such patients were hospitalized with RSV infections. Six patients, including all five patients who were early post transplant in the pre-engraftment period, developed pneumonia and were treated with a combination of aerosolized ribavirin and IVIG. Among five patients with pneumonia in whom therapy was initiated prior to respiratory failure, one (20%) died. The sixth patient, in whom therapy was initiated after respiratory failure developed, also died. In total, two (1%) patients, both of whom were in the pre-engraftment period, died of progressive pneumonia. In conclusion, RSV is a significant cause of life-threatening pneumonia in autologous BMT recipients with breast cancer during the early post-transplant period, and accounted for a substantial portion of the overall transplant-related mortality, which in recent years has been minimal.</abstract><cop>Basingstoke</cop><pub>Nature Publishing Group</pub><pmid>11535995</pmid><doi>10.1038/sj.bmt.1703131</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 0268-3369 |
| ispartof | Bone marrow transplantation (Basingstoke), 2001-08, Vol.28 (3), p.271-275 |
| issn | 0268-3369 1476-5365 |
| language | eng |
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| source | MEDLINE; Nature; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; SpringerLink Journals - AutoHoldings |
| subjects | Aerosols Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Antibiotics. Antiinfectious agents. Antiparasitic agents Antineoplastic Combined Chemotherapy Protocols - administration & dosage Antineoplastic Combined Chemotherapy Protocols - toxicity Antiviral agents Antiviral Agents - administration & dosage Autografts Biological and medical sciences Blood Bone marrow Bone marrow transplantation Bone Marrow Transplantation - adverse effects Bone Marrow Transplantation - mortality Bone marrow, stem cells transplantation. Graft versus host reaction Breast cancer Breast Neoplasms - complications Breast Neoplasms - therapy Disease Progression Female Hematopoietic Stem Cell Transplantation - adverse effects Hematopoietic Stem Cell Transplantation - mortality Humans Immunoglobulins Immunoglobulins, Intravenous - administration & dosage Infections Intravenous administration Medical sciences Pharmacology. Drug treatments Pneumonia Pneumonia, Viral - chemically induced Pneumonia, Viral - drug therapy Pneumonia, Viral - mortality Respiratory failure Respiratory syncytial virus Respiratory Syncytial Virus Infections - chemically induced Respiratory Syncytial Virus Infections - drug therapy Respiratory Syncytial Virus Infections - mortality Retrospective Studies Ribavirin Ribavirin - administration & dosage Stem cell transplantation Survival Rate Therapy Transfusions. Complications. Transfusion reactions. Cell and gene therapy Transplantation Transplantation, Autologous - adverse effects Transplantation, Autologous - mortality Transplants & implants Viruses |
| title | Respiratory syncytial virus infections in autologous blood and marrow transplant recipients with breast cancer : combination therapy with aerosolized ribavirin and parenteral immunoglobulins |
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