In situ demonstration of intraepithelial lymphocyte adhesion to villus microvessels of the small intestine

The recirculation of lymphocytes through the intestinal mucosa is important for specific immune defense, but the origin and differentiation of intraepithelial lymphocytes (IEL) are not fully understood. The present study therefore used intravital microscopy to investigate the migration of IEL to the...

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Veröffentlicht in:	International immunology 2001-09, Vol.13 (9), p.1165-1174
Hauptverfasser:	Koseki, Seiichiro, Miura, Soichiro, Fujimori, Hitoshi, Hokari, Ryota, Komoto, Shunsuke, Hara, Yuriko, Ogino, Tsuyoshi, Nagata, Hiroshi, Goto, Masao, Hachimura, Satoshi, Kaminogawa, Shuichi, Ishii, Hiromasa
Format:	Artikel
Sprache:	eng
Schlagworte:	adhesion molecules Animals Antigens, CD CD4 Antigens Cell Adhesion Cell Adhesion Molecules Cell Differentiation Cell Movement cell trafficking CFSE carboxyfluorescein succinimidyl ester Female HEV high endothelial venule IEL intraepithelial lymphocyte Immunoglobulins Integrin alpha Chains Integrin beta Chains Integrins Intestinal Mucosa - cytology Intestinal Mucosa - immunology Intestine, Small - blood supply Intestine, Small - cytology Intestine, Small - immunology intraepithelial lymphocytes Lymph Nodes - cytology Lymph Nodes - immunology Lymphocyte Subsets - cytology Lymphocyte Subsets - immunology Lymphocytes - cytology Lymphocytes - immunology MAdCAM mucosal addressin cell adhesion molecule Male Mesentery - cytology Mesentery - immunology Mice Mice, Inbred BALB C Mice, Inbred C57BL Microcirculation - cytology Microcirculation - immunology MLNL mesenteric lymph node lymphocyte Mucoproteins mucosal addressin cell adhesion molecule mucosal addressin cell adhesion molecule-1 PCV postcapillary venules Peyer's Patches - blood supply Peyer's Patches - cytology Peyer's Patches - immunology PTX pertussis toxin Receptors, Antigen, T-Cell, alpha-beta Receptors, Lymphocyte Homing β7-integrin
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