Cu super(2+)-selective ratiometric fluorescence signaling probe based on the hydrolysis of dansylhydrazine

A simple Cu super(2+)-selective ratiometric fluorescence signaling probe based on the hydrolysis of dansylhydrazine was developed. Dansylhydrazine 1 showed prominent ratiometric fluorescence signaling behavior toward Cu super(2+) ions in a 50% aqueous (pH 7.4) acetonitrile solution. The ratiometric...

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Veröffentlicht in:	Tetrahedron letters 2016-03, Vol.57 (9), p.975-978
Hauptverfasser:	Choi, Myung Gil, Kim, Jieun, Hong, Ja Min, Chang, In Jung, Ahn, Sangdoo, Chang, Suk-Kyu
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetonitrile Copper Fluorescence Hydrolysis Metal ions Tetrahedrons Urine
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creator	Choi, Myung Gil Kim, Jieun Hong, Ja Min Chang, In Jung Ahn, Sangdoo Chang, Suk-Kyu
description	A simple Cu super(2+)-selective ratiometric fluorescence signaling probe based on the hydrolysis of dansylhydrazine was developed. Dansylhydrazine 1 showed prominent ratiometric fluorescence signaling behavior toward Cu super(2+) ions in a 50% aqueous (pH 7.4) acetonitrile solution. The ratiometric signaling behavior was due to the Cu super(2+)-assisted hydrolysis of the yellow-colored fluorescent dansylhydrazine to strongly blue-fluorescent dansyl acid. The Cu super(2+)-selective signaling of probe 1 was not affected by the presence of biologically important metal ions. The ratiometric signaling of Cu super(2+) by 1 was possible with a detection limit of 6.0 10 super(-8) M (3.8 ppb). In addition, the signaling of Cu super(2+) in biological samples using synthetic urine was also tested. InChIKeys * WAZWAZXWPDTCKG-UHFFFAOYSA-N * KPQYDVAFRDWIBW-UHFFFAOYSA-N
doi_str_mv	10.1016/j.tetlet.2016.01.052
format	Article
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Dansylhydrazine 1 showed prominent ratiometric fluorescence signaling behavior toward Cu super(2+) ions in a 50% aqueous (pH 7.4) acetonitrile solution. The ratiometric signaling behavior was due to the Cu super(2+)-assisted hydrolysis of the yellow-colored fluorescent dansylhydrazine to strongly blue-fluorescent dansyl acid. The Cu super(2+)-selective signaling of probe 1 was not affected by the presence of biologically important metal ions. The ratiometric signaling of Cu super(2+) by 1 was possible with a detection limit of 6.0 10 super(-8) M (3.8 ppb). In addition, the signaling of Cu super(2+) in biological samples using synthetic urine was also tested. 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Dansylhydrazine 1 showed prominent ratiometric fluorescence signaling behavior toward Cu super(2+) ions in a 50% aqueous (pH 7.4) acetonitrile solution. The ratiometric signaling behavior was due to the Cu super(2+)-assisted hydrolysis of the yellow-colored fluorescent dansylhydrazine to strongly blue-fluorescent dansyl acid. The Cu super(2+)-selective signaling of probe 1 was not affected by the presence of biologically important metal ions. The ratiometric signaling of Cu super(2+) by 1 was possible with a detection limit of 6.0 10 super(-8) M (3.8 ppb). In addition, the signaling of Cu super(2+) in biological samples using synthetic urine was also tested. InChIKeys * WAZWAZXWPDTCKG-UHFFFAOYSA-N * KPQYDVAFRDWIBW-UHFFFAOYSA-N</description><subject>Acetonitrile</subject><subject>Copper</subject><subject>Fluorescence</subject><subject>Hydrolysis</subject><subject>Metal ions</subject><subject>Tetrahedrons</subject><subject>Urine</subject><issn>0040-4039</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><recordid>eNqVjc1OwzAQhH0AqeXnDXrYYxGKu05ClJwrEA_AvXKTTetoaxevjRSeniDxAsxlNJ9GM0ptDGqDptlNOlFiSrpckkaj8aW8UWvEGosaq26l7kQmXNS0uFbTPoPkK8Vt-fxUCDH1yX0RRJtcuFCKroeRc4gkPfmeQNzJW3b-BNcYjgRHKzRA8JDOBOd5iIFncQJhhMF6mfmX2W_n6UHdjpaFHv_8Xm3fXj_278Uy9JlJ0uHilhNm6ylkOZgWu6aqurqt_lH9AaJ8U9w</recordid><startdate>20160302</startdate><enddate>20160302</enddate><creator>Choi, Myung Gil</creator><creator>Kim, Jieun</creator><creator>Hong, Ja Min</creator><creator>Chang, In Jung</creator><creator>Ahn, Sangdoo</creator><creator>Chang, Suk-Kyu</creator><scope>7SR</scope><scope>8BQ</scope><scope>8FD</scope><scope>JG9</scope></search><sort><creationdate>20160302</creationdate><title>Cu super(2+)-selective ratiometric fluorescence signaling probe based on the hydrolysis of dansylhydrazine</title><author>Choi, Myung Gil ; Kim, Jieun ; Hong, Ja Min ; Chang, In Jung ; Ahn, Sangdoo ; Chang, Suk-Kyu</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-proquest_miscellaneous_18096339483</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Acetonitrile</topic><topic>Copper</topic><topic>Fluorescence</topic><topic>Hydrolysis</topic><topic>Metal ions</topic><topic>Tetrahedrons</topic><topic>Urine</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Choi, Myung Gil</creatorcontrib><creatorcontrib>Kim, Jieun</creatorcontrib><creatorcontrib>Hong, Ja Min</creatorcontrib><creatorcontrib>Chang, In Jung</creatorcontrib><creatorcontrib>Ahn, Sangdoo</creatorcontrib><creatorcontrib>Chang, Suk-Kyu</creatorcontrib><collection>Engineered Materials Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>Materials Research Database</collection><jtitle>Tetrahedron letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Choi, Myung Gil</au><au>Kim, Jieun</au><au>Hong, Ja Min</au><au>Chang, In Jung</au><au>Ahn, Sangdoo</au><au>Chang, Suk-Kyu</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cu super(2+)-selective ratiometric fluorescence signaling probe based on the hydrolysis of dansylhydrazine</atitle><jtitle>Tetrahedron letters</jtitle><date>2016-03-02</date><risdate>2016</risdate><volume>57</volume><issue>9</issue><spage>975</spage><epage>978</epage><pages>975-978</pages><issn>0040-4039</issn><abstract>A simple Cu super(2+)-selective ratiometric fluorescence signaling probe based on the hydrolysis of dansylhydrazine was developed. Dansylhydrazine 1 showed prominent ratiometric fluorescence signaling behavior toward Cu super(2+) ions in a 50% aqueous (pH 7.4) acetonitrile solution. The ratiometric signaling behavior was due to the Cu super(2+)-assisted hydrolysis of the yellow-colored fluorescent dansylhydrazine to strongly blue-fluorescent dansyl acid. The Cu super(2+)-selective signaling of probe 1 was not affected by the presence of biologically important metal ions. The ratiometric signaling of Cu super(2+) by 1 was possible with a detection limit of 6.0 10 super(-8) M (3.8 ppb). In addition, the signaling of Cu super(2+) in biological samples using synthetic urine was also tested. InChIKeys * WAZWAZXWPDTCKG-UHFFFAOYSA-N * KPQYDVAFRDWIBW-UHFFFAOYSA-N</abstract><doi>10.1016/j.tetlet.2016.01.052</doi></addata></record>
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subjects	Acetonitrile Copper Fluorescence Hydrolysis Metal ions Tetrahedrons Urine
title	Cu super(2+)-selective ratiometric fluorescence signaling probe based on the hydrolysis of dansylhydrazine
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