Effect of secondary anchor amino acid substitutions on the immunogenic properties of an HLA-A0201-restricted T cell epitope derived from the Trypanosoma cruzi KMP-11 protein

•Residues 3, 6 and 7 of TcTLE (TLEEFSAKL) peptide are critical for binding affinity.•Amino acids at positions 3, 6 and 7 of TcTLE have limited effect on immunogenicity.•Binding affinity is not the only parameter to evaluate immunogenic peptides. The TcTLE peptide (TLEEFSAKL) is a CD8+ T cell HLA-A*0...

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Veröffentlicht in:	Peptides (New York, N.Y. : 1980) N.Y. : 1980), 2016-04, Vol.78, p.68-76
Hauptverfasser:	Lasso, Paola, Cárdenas, Constanza, Guzmán, Fanny, Rosas, Fernando, Thomas, María Carmen, López, Manuel Carlos, González, John Mario, Cuéllar, Adriana, Campanera, Josep Maria, Luque, F. Javier, Puerta, Concepción Judith
Format:	Artikel
Sprache:	eng
Schlagworte:	Affinity Amino Acid Sequence Amino Acid Substitution Amino acids Anchors Antibodies, Protozoan - biosynthesis Binding Binding Sites CD8+ T cells CD8-Positive T-Lymphocytes - cytology CD8-Positive T-Lymphocytes - drug effects CD8-Positive T-Lymphocytes - immunology Cell Line Chagas disease Chagas Disease - immunology Chagas Disease - parasitology Epitopes, T-Lymphocyte - chemistry Epitopes, T-Lymphocyte - genetics Epitopes, T-Lymphocyte - immunology Gene Expression Regulation HLA-A2 Antigen - chemistry HLA-A2 Antigen - genetics HLA-A2 Antigen - immunology Humans Interferon-gamma - genetics Interferon-gamma - immunology Lysosomal-Associated Membrane Protein 1 - genetics Lysosomal-Associated Membrane Protein 1 - immunology Lysosomal-Associated Membrane Protein 2 - genetics Lysosomal-Associated Membrane Protein 2 - immunology MHC class I Mutation Mutations Patients Peptides Peptides - chemical synthesis Peptides - immunology Peptides - pharmacology Protein Binding Proteins Protozoan Proteins - chemistry Protozoan Proteins - immunology Trypanosoma cruzi Trypanosoma cruzi - chemistry Trypanosoma cruzi - immunology Tumor Necrosis Factor-alpha - genetics Tumor Necrosis Factor-alpha - immunology
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