Multifunctional mesoporous bioactive glass/upconversion nanoparticle nanocomposites with strong red emission to monitor drug delivery and stimulate osteogenic differentiation of stem cells
For the therapy and regeneration of bone defects resulting from malignant bone tumors, it is necessary to develop multifunctional biomaterials that are able to deliver therapeutic drugs, monitor drug release, and stimulate bone formation. Herein, a multifunctional mesoporous bioactive glass （MBG）/up...
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| Veröffentlicht in: | Nano research 2016-04, Vol.9 (4), p.1193-1208 |
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| description | For the therapy and regeneration of bone defects resulting from malignant bone tumors, it is necessary to develop multifunctional biomaterials that are able to deliver therapeutic drugs, monitor drug release, and stimulate bone formation. Herein, a multifunctional mesoporous bioactive glass （MBG）/upconversion nanoparticle （UCNP） nanocomposite [UCNPs@SiO2@mSiO2-XCa （X = 0, 5, 10, 15, and 20）] with the ability to deliver anti-cancer drugs, monitor drug release, and stimulate osteogenic differentiation of bone marrow stromal cells （BMSCs） was successfully prepared using a layer-by-layer strategy. The nanocomposite spheres possess a core--sheU structure composed of UCNPs and a mesoporous SiO2/Ca layer with a uniform size distribution of 100 nm. The incorporation of Ca into the nanocomposites induced phase transformation from a pure hexagonal phase to a cubic phase, and facilitated the occurrence of red emission, which significantly improved fluorescence penetration for deep tissue imaging. In addition, since the red emission strongly overlaps with the maximum absorbance of the anti-cancer drug zinc phthalocyanine （ZnPc）, red luminescence could be strongly quenched by ZnPc. Consequently, drug release could be quantified by monitoring changes in fluorescence intensity. Furthermore, the incorporation of Ca into MBG/UCNP nanocomposites remarkably improved bioactivity, i.e., it stimulated apatite mineralization in simulated body fluids and enhanced cell proliferation and bone-related gene expression in BMSCs for the concentration range of 200-500 ~g/mL. Our results suggest that the prepared MBG/UCNP nanocomposites are useful for the therapy and regeneration of bone defects resulting from malignant bone tumors owing to their distinct multifunctionality, including strong red emission and functions in drug-delivery monitoring and osteostimulation. |
| doi_str_mv | 10.1007/s12274-016-1015-z |
| format | Article |
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Herein, a multifunctional mesoporous bioactive glass （MBG）/upconversion nanoparticle （UCNP） nanocomposite [UCNPs@SiO2@mSiO2-XCa （X = 0, 5, 10, 15, and 20）] with the ability to deliver anti-cancer drugs, monitor drug release, and stimulate osteogenic differentiation of bone marrow stromal cells （BMSCs） was successfully prepared using a layer-by-layer strategy. The nanocomposite spheres possess a core--sheU structure composed of UCNPs and a mesoporous SiO2/Ca layer with a uniform size distribution of 100 nm. The incorporation of Ca into the nanocomposites induced phase transformation from a pure hexagonal phase to a cubic phase, and facilitated the occurrence of red emission, which significantly improved fluorescence penetration for deep tissue imaging. In addition, since the red emission strongly overlaps with the maximum absorbance of the anti-cancer drug zinc phthalocyanine （ZnPc）, red luminescence could be strongly quenched by ZnPc. Consequently, drug release could be quantified by monitoring changes in fluorescence intensity. Furthermore, the incorporation of Ca into MBG/UCNP nanocomposites remarkably improved bioactivity, i.e., it stimulated apatite mineralization in simulated body fluids and enhanced cell proliferation and bone-related gene expression in BMSCs for the concentration range of 200-500 ~g/mL. Our results suggest that the prepared MBG/UCNP nanocomposites are useful for the therapy and regeneration of bone defects resulting from malignant bone tumors owing to their distinct multifunctionality, including strong red emission and functions in drug-delivery monitoring and osteostimulation.</description><identifier>ISSN: 1998-0124</identifier><identifier>EISSN: 1998-0000</identifier><identifier>DOI: 10.1007/s12274-016-1015-z</identifier><language>eng</language><publisher>Beijing: Tsinghua University Press</publisher><subject>Apatite ; Atomic/Molecular Structure and Spectra ; Biocompatibility ; Biological activity ; Biomaterials ; Biomedical materials ; Biomedicine ; Biotechnology ; Body fluids ; Bone biomaterials ; Bone cancer ; Bone growth ; Bone marrow ; Bone tumors ; Bones ; Cancer ; Cell proliferation ; Chemistry and Materials Science ; Condensed Matter Physics ; Defects ; Differentiation ; Drug delivery ; Drug delivery systems ; Emission ; Emission spectra ; Emissions ; Fluorescence ; Gene expression ; Hexagonal phase ; In vitro methods and tests ; Materials Science ; Mineralization ; Monitors ; Nanocomposites ; Nanoparticles ; Nanostructure ; Nanotechnology ; Osteogenesis ; Phase transitions ; Pollution monitoring ; Regeneration ; Research Article ; Silicon dioxide ; Size distribution ; Stem cells ; Stromal cells ; Surgical implants ; Therapy ; Tumors ; 介孔SiO2 ; 多功能性 ; 干细胞 ; 成骨细胞分化 ; 生物活性玻璃 ; 红光发射 ; 纳米复合材料 ; 药物输送</subject><ispartof>Nano research, 2016-04, Vol.9 (4), p.1193-1208</ispartof><rights>Tsinghua University Press and Springer-Verlag Berlin Heidelberg 2016</rights><rights>Nano Research is a copyright of Springer, (2016). All Rights Reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c409t-ffc8cd4b5ba5200d288386d758e9ca8e0e058433984d3f4f83afbde3c22aac4f3</citedby><cites>FETCH-LOGICAL-c409t-ffc8cd4b5ba5200d288386d758e9ca8e0e058433984d3f4f83afbde3c22aac4f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Uhttp://image.cqvip.com/vip1000/qk/71233X/71233X.jpg</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s12274-016-1015-z$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s12274-016-1015-z$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids></links><search><creatorcontrib>Wang, Fangfang</creatorcontrib><creatorcontrib>Zhai, Dong</creatorcontrib><creatorcontrib>Wu, Chengtie</creatorcontrib><creatorcontrib>Chang, Jiang</creatorcontrib><title>Multifunctional mesoporous bioactive glass/upconversion nanoparticle nanocomposites with strong red emission to monitor drug delivery and stimulate osteogenic differentiation of stem cells</title><title>Nano research</title><addtitle>Nano Res</addtitle><addtitle>Nano Research</addtitle><description>For the therapy and regeneration of bone defects resulting from malignant bone tumors, it is necessary to develop multifunctional biomaterials that are able to deliver therapeutic drugs, monitor drug release, and stimulate bone formation. Herein, a multifunctional mesoporous bioactive glass （MBG）/upconversion nanoparticle （UCNP） nanocomposite [UCNPs@SiO2@mSiO2-XCa （X = 0, 5, 10, 15, and 20）] with the ability to deliver anti-cancer drugs, monitor drug release, and stimulate osteogenic differentiation of bone marrow stromal cells （BMSCs） was successfully prepared using a layer-by-layer strategy. The nanocomposite spheres possess a core--sheU structure composed of UCNPs and a mesoporous SiO2/Ca layer with a uniform size distribution of 100 nm. The incorporation of Ca into the nanocomposites induced phase transformation from a pure hexagonal phase to a cubic phase, and facilitated the occurrence of red emission, which significantly improved fluorescence penetration for deep tissue imaging. In addition, since the red emission strongly overlaps with the maximum absorbance of the anti-cancer drug zinc phthalocyanine （ZnPc）, red luminescence could be strongly quenched by ZnPc. Consequently, drug release could be quantified by monitoring changes in fluorescence intensity. Furthermore, the incorporation of Ca into MBG/UCNP nanocomposites remarkably improved bioactivity, i.e., it stimulated apatite mineralization in simulated body fluids and enhanced cell proliferation and bone-related gene expression in BMSCs for the concentration range of 200-500 ~g/mL. Our results suggest that the prepared MBG/UCNP nanocomposites are useful for the therapy and regeneration of bone defects resulting from malignant bone tumors owing to their distinct multifunctionality, including strong red emission and functions in drug-delivery monitoring and osteostimulation.</description><subject>Apatite</subject><subject>Atomic/Molecular Structure and Spectra</subject><subject>Biocompatibility</subject><subject>Biological activity</subject><subject>Biomaterials</subject><subject>Biomedical materials</subject><subject>Biomedicine</subject><subject>Biotechnology</subject><subject>Body fluids</subject><subject>Bone biomaterials</subject><subject>Bone cancer</subject><subject>Bone growth</subject><subject>Bone marrow</subject><subject>Bone tumors</subject><subject>Bones</subject><subject>Cancer</subject><subject>Cell proliferation</subject><subject>Chemistry and Materials Science</subject><subject>Condensed Matter 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Research</addtitle><date>2016-04-01</date><risdate>2016</risdate><volume>9</volume><issue>4</issue><spage>1193</spage><epage>1208</epage><pages>1193-1208</pages><issn>1998-0124</issn><eissn>1998-0000</eissn><abstract>For the therapy and regeneration of bone defects resulting from malignant bone tumors, it is necessary to develop multifunctional biomaterials that are able to deliver therapeutic drugs, monitor drug release, and stimulate bone formation. Herein, a multifunctional mesoporous bioactive glass （MBG）/upconversion nanoparticle （UCNP） nanocomposite [UCNPs@SiO2@mSiO2-XCa （X = 0, 5, 10, 15, and 20）] with the ability to deliver anti-cancer drugs, monitor drug release, and stimulate osteogenic differentiation of bone marrow stromal cells （BMSCs） was successfully prepared using a layer-by-layer strategy. The nanocomposite spheres possess a core--sheU structure composed of UCNPs and a mesoporous SiO2/Ca layer with a uniform size distribution of 100 nm. The incorporation of Ca into the nanocomposites induced phase transformation from a pure hexagonal phase to a cubic phase, and facilitated the occurrence of red emission, which significantly improved fluorescence penetration for deep tissue imaging. In addition, since the red emission strongly overlaps with the maximum absorbance of the anti-cancer drug zinc phthalocyanine （ZnPc）, red luminescence could be strongly quenched by ZnPc. Consequently, drug release could be quantified by monitoring changes in fluorescence intensity. Furthermore, the incorporation of Ca into MBG/UCNP nanocomposites remarkably improved bioactivity, i.e., it stimulated apatite mineralization in simulated body fluids and enhanced cell proliferation and bone-related gene expression in BMSCs for the concentration range of 200-500 ~g/mL. Our results suggest that the prepared MBG/UCNP nanocomposites are useful for the therapy and regeneration of bone defects resulting from malignant bone tumors owing to their distinct multifunctionality, including strong red emission and functions in drug-delivery monitoring and osteostimulation.</abstract><cop>Beijing</cop><pub>Tsinghua University Press</pub><doi>10.1007/s12274-016-1015-z</doi><tpages>16</tpages></addata></record> |
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| source | SpringerNature Journals |
| subjects | Apatite Atomic/Molecular Structure and Spectra Biocompatibility Biological activity Biomaterials Biomedical materials Biomedicine Biotechnology Body fluids Bone biomaterials Bone cancer Bone growth Bone marrow Bone tumors Bones Cancer Cell proliferation Chemistry and Materials Science Condensed Matter Physics Defects Differentiation Drug delivery Drug delivery systems Emission Emission spectra Emissions Fluorescence Gene expression Hexagonal phase In vitro methods and tests Materials Science Mineralization Monitors Nanocomposites Nanoparticles Nanostructure Nanotechnology Osteogenesis Phase transitions Pollution monitoring Regeneration Research Article Silicon dioxide Size distribution Stem cells Stromal cells Surgical implants Therapy Tumors 介孔SiO2 多功能性 干细胞 成骨细胞分化 生物活性玻璃 红光发射 纳米复合材料 药物输送 |
| title | Multifunctional mesoporous bioactive glass/upconversion nanoparticle nanocomposites with strong red emission to monitor drug delivery and stimulate osteogenic differentiation of stem cells |
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