Endometrial thickness as a predictor of pregnancy outcomes in 10787 fresh IVF–ICSI cycles
Abstract This retrospective study assessed the predictive value of endometrial thickness (EMT) on HCG administration day for the clinical outcome of fresh IVF and intracytoplasmic sperm injection (ICSI) cycles. A total of 8690 consecutive women undergoing 10,787 cycles over a 5-year period were incl...
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| Veröffentlicht in: | Reproductive biomedicine online 2016-08, Vol.33 (2), p.197-205 |
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| creator | Yuan, Xi Saravelos, Sotirios H Wang, Qiong Xu, Yanwen Li, Tin-Chiu Zhou, Canquan |
| description | Abstract This retrospective study assessed the predictive value of endometrial thickness (EMT) on HCG administration day for the clinical outcome of fresh IVF and intracytoplasmic sperm injection (ICSI) cycles. A total of 8690 consecutive women undergoing 10,787 cycles over a 5-year period were included. The 5th, 50th and 95th centiles for EMT were determined as 8, 11 and 15 mm, respectively. Group analysis according to these centiles (Group 1: 11 and ≤15 mm; Group 4: >15 mm) demonstrated significant differences ( P < 0.001) in clinical pregnancy rates (23.0%, 37.2%, 46.2% and 53.3%, respectively), live birth rates per clinical pregnancy (63.3%, 72.0%, 78.1% and 80.3%, respectively), spontaneous abortion rates (26.7%, 23.8%, 19.9% and 17.5%, respectively), and ectopic pregnancy rates (10.0%, 4.3%, 2.1% and 2.2%, respectively). Logistic regression analyses showed EMT as one of the independent variables predictive of clinical pregnancy (OR = 1.097; P < 0.001), live birth (OR = 1.078; P < 0.001), spontaneous abortion (OR = 0.948; P < 0.001), and ectopic pregnancy (OR = 0.851; P < 0.001). Future research should aim to understand the underlying mechanisms relating EMT to conception, ectopic implantation and spontaneous abortion. |
| doi_str_mv | 10.1016/j.rbmo.2016.05.002 |
| format | Article |
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A total of 8690 consecutive women undergoing 10,787 cycles over a 5-year period were included. The 5th, 50th and 95th centiles for EMT were determined as 8, 11 and 15 mm, respectively. Group analysis according to these centiles (Group 1: <8 mm; Group 2: ≥8 and ≤11 mm; Group 3: >11 and ≤15 mm; Group 4: >15 mm) demonstrated significant differences ( P < 0.001) in clinical pregnancy rates (23.0%, 37.2%, 46.2% and 53.3%, respectively), live birth rates per clinical pregnancy (63.3%, 72.0%, 78.1% and 80.3%, respectively), spontaneous abortion rates (26.7%, 23.8%, 19.9% and 17.5%, respectively), and ectopic pregnancy rates (10.0%, 4.3%, 2.1% and 2.2%, respectively). Logistic regression analyses showed EMT as one of the independent variables predictive of clinical pregnancy (OR = 1.097; P < 0.001), live birth (OR = 1.078; P < 0.001), spontaneous abortion (OR = 0.948; P < 0.001), and ectopic pregnancy (OR = 0.851; P < 0.001). Future research should aim to understand the underlying mechanisms relating EMT to conception, ectopic implantation and spontaneous abortion.]]></description><identifier>ISSN: 1472-6483</identifier><identifier>EISSN: 1472-6491</identifier><identifier>DOI: 10.1016/j.rbmo.2016.05.002</identifier><identifier>PMID: 27238372</identifier><language>eng</language><publisher>Netherlands: Elsevier Ltd</publisher><subject>Abortion, Spontaneous - diagnosis ; Adult ; Chorionic Gonadotropin - metabolism ; clinical outcome ; endometrial thickness ; endometrium ; Endometrium - physiology ; Female ; Fertilization in Vitro - methods ; Humans ; IVF–ICSI ; Live Birth ; Male ; Maternal Age ; Obstetrics and Gynecology ; Predictive Value of Tests ; Pregnancy ; Pregnancy Outcome ; Pregnancy Rate ; Regression Analysis ; Retrospective Studies ; Single Embryo Transfer ; Sperm Injections, Intracytoplasmic - methods</subject><ispartof>Reproductive biomedicine online, 2016-08, Vol.33 (2), p.197-205</ispartof><rights>2016 Reproductive Healthcare Ltd.</rights><rights>Copyright © 2016 Reproductive Healthcare Ltd. Published by Elsevier Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c455t-3384d1a50acb6157e59b866ded6dce61a2ed81c3566776c998b3bbee634734863</citedby><cites>FETCH-LOGICAL-c455t-3384d1a50acb6157e59b866ded6dce61a2ed81c3566776c998b3bbee634734863</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.rbmo.2016.05.002$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27238372$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yuan, Xi</creatorcontrib><creatorcontrib>Saravelos, Sotirios H</creatorcontrib><creatorcontrib>Wang, Qiong</creatorcontrib><creatorcontrib>Xu, Yanwen</creatorcontrib><creatorcontrib>Li, Tin-Chiu</creatorcontrib><creatorcontrib>Zhou, Canquan</creatorcontrib><title>Endometrial thickness as a predictor of pregnancy outcomes in 10787 fresh IVF–ICSI cycles</title><title>Reproductive biomedicine online</title><addtitle>Reprod Biomed Online</addtitle><description><![CDATA[Abstract This retrospective study assessed the predictive value of endometrial thickness (EMT) on HCG administration day for the clinical outcome of fresh IVF and intracytoplasmic sperm injection (ICSI) cycles. A total of 8690 consecutive women undergoing 10,787 cycles over a 5-year period were included. The 5th, 50th and 95th centiles for EMT were determined as 8, 11 and 15 mm, respectively. Group analysis according to these centiles (Group 1: <8 mm; Group 2: ≥8 and ≤11 mm; Group 3: >11 and ≤15 mm; Group 4: >15 mm) demonstrated significant differences ( P < 0.001) in clinical pregnancy rates (23.0%, 37.2%, 46.2% and 53.3%, respectively), live birth rates per clinical pregnancy (63.3%, 72.0%, 78.1% and 80.3%, respectively), spontaneous abortion rates (26.7%, 23.8%, 19.9% and 17.5%, respectively), and ectopic pregnancy rates (10.0%, 4.3%, 2.1% and 2.2%, respectively). Logistic regression analyses showed EMT as one of the independent variables predictive of clinical pregnancy (OR = 1.097; P < 0.001), live birth (OR = 1.078; P < 0.001), spontaneous abortion (OR = 0.948; P < 0.001), and ectopic pregnancy (OR = 0.851; P < 0.001). Future research should aim to understand the underlying mechanisms relating EMT to conception, ectopic implantation and spontaneous abortion.]]></description><subject>Abortion, Spontaneous - diagnosis</subject><subject>Adult</subject><subject>Chorionic Gonadotropin - metabolism</subject><subject>clinical outcome</subject><subject>endometrial thickness</subject><subject>endometrium</subject><subject>Endometrium - physiology</subject><subject>Female</subject><subject>Fertilization in Vitro - methods</subject><subject>Humans</subject><subject>IVF–ICSI</subject><subject>Live Birth</subject><subject>Male</subject><subject>Maternal Age</subject><subject>Obstetrics and Gynecology</subject><subject>Predictive Value of Tests</subject><subject>Pregnancy</subject><subject>Pregnancy Outcome</subject><subject>Pregnancy Rate</subject><subject>Regression Analysis</subject><subject>Retrospective Studies</subject><subject>Single Embryo Transfer</subject><subject>Sperm Injections, Intracytoplasmic - methods</subject><issn>1472-6483</issn><issn>1472-6491</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kc2KFDEUhYMozo--gAvJ0k2X-alKUiCCNDNjw4CLUTcuQurWbSc9VUmbVA30znfwDX0SU_Q4CxdCIPfCOQfOdwl5xVnFGVdvd1XqxliJMlesqRgTT8gpr7VYqbrlTx9nI0_IWc47xrhhRj4nJ0ILaaQWp-TbRejjiFPybqDTrYe7gDlTVx7dJ-w9TDHRuF2W78EFONA4T1AsmfpAOdNG023CfEs3Xy9___y1Wd9sKBxgwPyCPNu6IePLh_-cfLm8-Lz-uLr-dLVZf7heQd0000pKU_fcNcxBp3ijsWk7o1SPveoBFXcCe8NBNkppraBtTSe7DlHJWsvaKHlO3hxz9yn-mDFPdvQZcBhcwDhnW1q3qhRXokjFUQop5pxwa_fJjy4dLGd2gWp3doFqF6iWNbZALabXD_lzN2L_aPlLsQjeHQVYWt57TDaDxwAFX0KYbB_9__Pf_2OHwQcPbrjDA-ZdnFMo_Cy3WVhmb5azLlflSjLRSib_AMTenK8</recordid><startdate>20160801</startdate><enddate>20160801</enddate><creator>Yuan, Xi</creator><creator>Saravelos, Sotirios H</creator><creator>Wang, Qiong</creator><creator>Xu, Yanwen</creator><creator>Li, Tin-Chiu</creator><creator>Zhou, Canquan</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20160801</creationdate><title>Endometrial thickness as a predictor of pregnancy outcomes in 10787 fresh IVF–ICSI cycles</title><author>Yuan, Xi ; Saravelos, Sotirios H ; Wang, Qiong ; Xu, Yanwen ; Li, Tin-Chiu ; Zhou, Canquan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c455t-3384d1a50acb6157e59b866ded6dce61a2ed81c3566776c998b3bbee634734863</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Abortion, Spontaneous - diagnosis</topic><topic>Adult</topic><topic>Chorionic Gonadotropin - metabolism</topic><topic>clinical outcome</topic><topic>endometrial thickness</topic><topic>endometrium</topic><topic>Endometrium - physiology</topic><topic>Female</topic><topic>Fertilization in Vitro - methods</topic><topic>Humans</topic><topic>IVF–ICSI</topic><topic>Live Birth</topic><topic>Male</topic><topic>Maternal Age</topic><topic>Obstetrics and Gynecology</topic><topic>Predictive Value of Tests</topic><topic>Pregnancy</topic><topic>Pregnancy Outcome</topic><topic>Pregnancy Rate</topic><topic>Regression Analysis</topic><topic>Retrospective Studies</topic><topic>Single Embryo Transfer</topic><topic>Sperm Injections, Intracytoplasmic - methods</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yuan, Xi</creatorcontrib><creatorcontrib>Saravelos, Sotirios H</creatorcontrib><creatorcontrib>Wang, Qiong</creatorcontrib><creatorcontrib>Xu, Yanwen</creatorcontrib><creatorcontrib>Li, Tin-Chiu</creatorcontrib><creatorcontrib>Zhou, Canquan</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Reproductive biomedicine online</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yuan, Xi</au><au>Saravelos, Sotirios H</au><au>Wang, Qiong</au><au>Xu, Yanwen</au><au>Li, Tin-Chiu</au><au>Zhou, Canquan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Endometrial thickness as a predictor of pregnancy outcomes in 10787 fresh IVF–ICSI cycles</atitle><jtitle>Reproductive biomedicine online</jtitle><addtitle>Reprod Biomed Online</addtitle><date>2016-08-01</date><risdate>2016</risdate><volume>33</volume><issue>2</issue><spage>197</spage><epage>205</epage><pages>197-205</pages><issn>1472-6483</issn><eissn>1472-6491</eissn><abstract><![CDATA[Abstract This retrospective study assessed the predictive value of endometrial thickness (EMT) on HCG administration day for the clinical outcome of fresh IVF and intracytoplasmic sperm injection (ICSI) cycles. A total of 8690 consecutive women undergoing 10,787 cycles over a 5-year period were included. The 5th, 50th and 95th centiles for EMT were determined as 8, 11 and 15 mm, respectively. Group analysis according to these centiles (Group 1: <8 mm; Group 2: ≥8 and ≤11 mm; Group 3: >11 and ≤15 mm; Group 4: >15 mm) demonstrated significant differences ( P < 0.001) in clinical pregnancy rates (23.0%, 37.2%, 46.2% and 53.3%, respectively), live birth rates per clinical pregnancy (63.3%, 72.0%, 78.1% and 80.3%, respectively), spontaneous abortion rates (26.7%, 23.8%, 19.9% and 17.5%, respectively), and ectopic pregnancy rates (10.0%, 4.3%, 2.1% and 2.2%, respectively). Logistic regression analyses showed EMT as one of the independent variables predictive of clinical pregnancy (OR = 1.097; P < 0.001), live birth (OR = 1.078; P < 0.001), spontaneous abortion (OR = 0.948; P < 0.001), and ectopic pregnancy (OR = 0.851; P < 0.001). Future research should aim to understand the underlying mechanisms relating EMT to conception, ectopic implantation and spontaneous abortion.]]></abstract><cop>Netherlands</cop><pub>Elsevier Ltd</pub><pmid>27238372</pmid><doi>10.1016/j.rbmo.2016.05.002</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Abortion, Spontaneous - diagnosis Adult Chorionic Gonadotropin - metabolism clinical outcome endometrial thickness endometrium Endometrium - physiology Female Fertilization in Vitro - methods Humans IVF–ICSI Live Birth Male Maternal Age Obstetrics and Gynecology Predictive Value of Tests Pregnancy Pregnancy Outcome Pregnancy Rate Regression Analysis Retrospective Studies Single Embryo Transfer Sperm Injections, Intracytoplasmic - methods |
| title | Endometrial thickness as a predictor of pregnancy outcomes in 10787 fresh IVF–ICSI cycles |
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