Transcriptomic and metabolic analyses reveal salvage pathways in creatine-deficient AGAT−/− mice

Skeletal muscles require energy either at constant low (e.g., standing and posture) or immediate high rates (e.g., exercise). To fulfill these requirements, myocytes utilize the phosphocreatine (PCr)/creatine (Cr) system as a fast energy buffer and shuttle. We have generated mice lacking l -arginine...

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Veröffentlicht in:	Amino acids 2016-08, Vol.48 (8), p.2025-2039
Hauptverfasser:	Stockebrand, Malte, Nejad, Ali Sasani, Neu, Axel, Kharbanda, Kusum K., Sauter, Kathrin, Schillemeit, Stefan, Isbrandt, Dirk, Choe, Chi-un
Format:	Artikel
Sprache:	eng
Schlagworte:	Adipose Tissue, White - metabolism Adipose Tissue, White - pathology Amidinotransferases - deficiency Amidinotransferases - genetics Amidinotransferases - metabolism Amino Acid Metabolism, Inborn Errors - genetics Amino Acid Metabolism, Inborn Errors - metabolism Amino Acid Metabolism, Inborn Errors - pathology Analytical Chemistry Animals Biochemical Engineering Biochemistry Biomedical and Life Sciences Creatine Developmental Disabilities - genetics Developmental Disabilities - metabolism Developmental Disabilities - pathology Intellectual Disability - genetics Intellectual Disability - metabolism Intellectual Disability - pathology Life Sciences Metabolome Mice Mice, Knockout Muscle, Skeletal - metabolism Muscle, Skeletal - pathology Neurobiology Obesity - chemically induced Obesity - genetics Obesity - metabolism Obesity - pathology Original Article Oxidative Phosphorylation Phosphocreatine - genetics Phosphocreatine - metabolism Proteomics Speech Disorders - genetics Speech Disorders - metabolism Speech Disorders - pathology Transcriptome
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