Predictive Factors for Lymph Node Metastasis in Papillary Thyroid Microcarcinoma
Background Because lymph node (LN) metastasis has been proven to be a predictor for locoregional recurrence (LRR) in papillary thyroid microcarcinoma (PTMC), better knowledge about the predictors for LN metastasis in PTMC is required. Methods We retrospectively reviewed 5656 PTMC patients who underw...
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| Veröffentlicht in: | Annals of surgical oncology 2016-09, Vol.23 (9), p.2866-2873 |
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| creator | Kim, Seo Ki Park, Inhye Woo, Jung-Woo Lee, Jun Ho Choe, Jun-Ho Kim, Jung-Han Kim, Jee Soo |
| description | Background
Because lymph node (LN) metastasis has been proven to be a predictor for locoregional recurrence (LRR) in papillary thyroid microcarcinoma (PTMC), better knowledge about the predictors for LN metastasis in PTMC is required.
Methods
We retrospectively reviewed 5656 PTMC patients who underwent total thyroidectomy and central neck dissection and/or lateral neck dissection between January 1997 and June 2015.
Results
Male gender (adjusted odds ratio [OR] 2.332), conventional variant (adjusted OR 4.266), tumor size >0.5 cm (adjusted OR 1.753), multiplicity (adjusted OR 1.168), bilaterality (adjusted OR 1.177), and extrathyroidal extension (ETE) (adjusted OR 1.448) were independent predictors for high prevalence of central LN metastasis (CLNM), whereas per 10-year age increment (adjusted OR 0.760) and chronic lymphocytic thyroiditis (adjusted OR 0.791) were independent predictors for low prevalence of CLNM. In addition, male gender (adjusted OR 1.489), tumor size >0.5 cm (adjusted OR 1.295), multiplicity (adjusted OR 1.801), ETE (adjusted OR 1.659), and CLNM (adjusted OR 4.359) were independent predictors for high prevalence of lateral LN metastasis (LLNM), whereas per 10-year age increment (adjusted OR 0.838) was an independent predictor for low prevalence of LLNM. There was a statistically significant difference in LRR with regard to nodal stage (
p
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| doi_str_mv | 10.1245/s10434-016-5225-0 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1809602011</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>4145550951</sourcerecordid><originalsourceid>FETCH-LOGICAL-c372t-a1b0a80312299d08294bb8149695db1d01eb8482e8b32ff38a7011bc2ad94c5c3</originalsourceid><addsrcrecordid>eNp1kE1LxDAQhoMofv8ALxLw4qU6kzRtchTxC1bdg55DmqYa2TZr0hX23xvZVUQQAhMyz_tm5iXkCOEMWSnOE0LJywKwKgRjooANsosiv5SVxM18h0oWilVih-yl9AaANQexTXZYDbXgDHfJdBpd6-3oPxy9NnYMMdEuRDpZ9vNX-hBaR-_daFI-PlE_0KmZ-9nMxCV9el3G4Ft6720M1kTrh9CbA7LVmVlyh-u6T56vr54ub4vJ483d5cWksLxmY2GwASOBI2NKtSCZKptGYqkqJdoGW0DXyFIyJxvOuo5LUwNiY5lpVWmF5fvkdOU7j-F94dKoe5-sy6MNLiySRgmqApZFGT35g76FRRzydJlCUDVHUWcKV1TeJqXoOj2Pvs-LagT9Fbdexa1z3Porbg1Zc7x2XjS9a38U3_lmgK2AlFvDi4u_vv7X9RP2Y4j9</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1810973157</pqid></control><display><type>article</type><title>Predictive Factors for Lymph Node Metastasis in Papillary Thyroid Microcarcinoma</title><source>MEDLINE</source><source>SpringerLink Journals</source><creator>Kim, Seo Ki ; Park, Inhye ; Woo, Jung-Woo ; Lee, Jun Ho ; Choe, Jun-Ho ; Kim, Jung-Han ; Kim, Jee Soo</creator><creatorcontrib>Kim, Seo Ki ; Park, Inhye ; Woo, Jung-Woo ; Lee, Jun Ho ; Choe, Jun-Ho ; Kim, Jung-Han ; Kim, Jee Soo</creatorcontrib><description>Background
Because lymph node (LN) metastasis has been proven to be a predictor for locoregional recurrence (LRR) in papillary thyroid microcarcinoma (PTMC), better knowledge about the predictors for LN metastasis in PTMC is required.
Methods
We retrospectively reviewed 5656 PTMC patients who underwent total thyroidectomy and central neck dissection and/or lateral neck dissection between January 1997 and June 2015.
Results
Male gender (adjusted odds ratio [OR] 2.332), conventional variant (adjusted OR 4.266), tumor size >0.5 cm (adjusted OR 1.753), multiplicity (adjusted OR 1.168), bilaterality (adjusted OR 1.177), and extrathyroidal extension (ETE) (adjusted OR 1.448) were independent predictors for high prevalence of central LN metastasis (CLNM), whereas per 10-year age increment (adjusted OR 0.760) and chronic lymphocytic thyroiditis (adjusted OR 0.791) were independent predictors for low prevalence of CLNM. In addition, male gender (adjusted OR 1.489), tumor size >0.5 cm (adjusted OR 1.295), multiplicity (adjusted OR 1.801), ETE (adjusted OR 1.659), and CLNM (adjusted OR 4.359) were independent predictors for high prevalence of lateral LN metastasis (LLNM), whereas per 10-year age increment (adjusted OR 0.838) was an independent predictor for low prevalence of LLNM. There was a statistically significant difference in LRR with regard to nodal stage (
p
< 0.001).
Conclusions
Meticulous perioperative evaluation of LN metastasis is required for PTMC patients with the above predictors.</description><identifier>ISSN: 1068-9265</identifier><identifier>EISSN: 1534-4681</identifier><identifier>DOI: 10.1245/s10434-016-5225-0</identifier><identifier>PMID: 27075321</identifier><language>eng</language><publisher>Cham: Springer International Publishing</publisher><subject>Adult ; Age Factors ; Aged ; Aged, 80 and over ; Carcinoma, Papillary - secondary ; Carcinoma, Papillary - surgery ; Endocrine Tumors ; Female ; Hashimoto Disease - complications ; Humans ; Lymph Nodes - pathology ; Lymph Nodes - surgery ; Lymphatic Metastasis ; Male ; Medicine ; Medicine & Public Health ; Middle Aged ; Neck Dissection ; Neoplasm Invasiveness ; Neoplasm Recurrence, Local - pathology ; Neoplasms, Multiple Primary - secondary ; Neoplasms, Multiple Primary - surgery ; Oncology ; Retrospective Studies ; Risk Factors ; Sex Factors ; Surgery ; Surgical Oncology ; Thyroid Neoplasms - pathology ; Thyroid Neoplasms - surgery ; Thyroidectomy ; Tumor Burden ; Young Adult</subject><ispartof>Annals of surgical oncology, 2016-09, Vol.23 (9), p.2866-2873</ispartof><rights>Society of Surgical Oncology 2016</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c372t-a1b0a80312299d08294bb8149695db1d01eb8482e8b32ff38a7011bc2ad94c5c3</citedby><cites>FETCH-LOGICAL-c372t-a1b0a80312299d08294bb8149695db1d01eb8482e8b32ff38a7011bc2ad94c5c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1245/s10434-016-5225-0$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1245/s10434-016-5225-0$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27075321$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kim, Seo Ki</creatorcontrib><creatorcontrib>Park, Inhye</creatorcontrib><creatorcontrib>Woo, Jung-Woo</creatorcontrib><creatorcontrib>Lee, Jun Ho</creatorcontrib><creatorcontrib>Choe, Jun-Ho</creatorcontrib><creatorcontrib>Kim, Jung-Han</creatorcontrib><creatorcontrib>Kim, Jee Soo</creatorcontrib><title>Predictive Factors for Lymph Node Metastasis in Papillary Thyroid Microcarcinoma</title><title>Annals of surgical oncology</title><addtitle>Ann Surg Oncol</addtitle><addtitle>Ann Surg Oncol</addtitle><description>Background
Because lymph node (LN) metastasis has been proven to be a predictor for locoregional recurrence (LRR) in papillary thyroid microcarcinoma (PTMC), better knowledge about the predictors for LN metastasis in PTMC is required.
Methods
We retrospectively reviewed 5656 PTMC patients who underwent total thyroidectomy and central neck dissection and/or lateral neck dissection between January 1997 and June 2015.
Results
Male gender (adjusted odds ratio [OR] 2.332), conventional variant (adjusted OR 4.266), tumor size >0.5 cm (adjusted OR 1.753), multiplicity (adjusted OR 1.168), bilaterality (adjusted OR 1.177), and extrathyroidal extension (ETE) (adjusted OR 1.448) were independent predictors for high prevalence of central LN metastasis (CLNM), whereas per 10-year age increment (adjusted OR 0.760) and chronic lymphocytic thyroiditis (adjusted OR 0.791) were independent predictors for low prevalence of CLNM. In addition, male gender (adjusted OR 1.489), tumor size >0.5 cm (adjusted OR 1.295), multiplicity (adjusted OR 1.801), ETE (adjusted OR 1.659), and CLNM (adjusted OR 4.359) were independent predictors for high prevalence of lateral LN metastasis (LLNM), whereas per 10-year age increment (adjusted OR 0.838) was an independent predictor for low prevalence of LLNM. There was a statistically significant difference in LRR with regard to nodal stage (
p
< 0.001).
Conclusions
Meticulous perioperative evaluation of LN metastasis is required for PTMC patients with the above predictors.</description><subject>Adult</subject><subject>Age Factors</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Carcinoma, Papillary - secondary</subject><subject>Carcinoma, Papillary - surgery</subject><subject>Endocrine Tumors</subject><subject>Female</subject><subject>Hashimoto Disease - complications</subject><subject>Humans</subject><subject>Lymph Nodes - pathology</subject><subject>Lymph Nodes - surgery</subject><subject>Lymphatic Metastasis</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Neck Dissection</subject><subject>Neoplasm Invasiveness</subject><subject>Neoplasm Recurrence, Local - pathology</subject><subject>Neoplasms, Multiple Primary - secondary</subject><subject>Neoplasms, Multiple Primary - surgery</subject><subject>Oncology</subject><subject>Retrospective Studies</subject><subject>Risk Factors</subject><subject>Sex Factors</subject><subject>Surgery</subject><subject>Surgical Oncology</subject><subject>Thyroid Neoplasms - pathology</subject><subject>Thyroid Neoplasms - surgery</subject><subject>Thyroidectomy</subject><subject>Tumor Burden</subject><subject>Young Adult</subject><issn>1068-9265</issn><issn>1534-4681</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp1kE1LxDAQhoMofv8ALxLw4qU6kzRtchTxC1bdg55DmqYa2TZr0hX23xvZVUQQAhMyz_tm5iXkCOEMWSnOE0LJywKwKgRjooANsosiv5SVxM18h0oWilVih-yl9AaANQexTXZYDbXgDHfJdBpd6-3oPxy9NnYMMdEuRDpZ9vNX-hBaR-_daFI-PlE_0KmZ-9nMxCV9el3G4Ft6720M1kTrh9CbA7LVmVlyh-u6T56vr54ub4vJ483d5cWksLxmY2GwASOBI2NKtSCZKptGYqkqJdoGW0DXyFIyJxvOuo5LUwNiY5lpVWmF5fvkdOU7j-F94dKoe5-sy6MNLiySRgmqApZFGT35g76FRRzydJlCUDVHUWcKV1TeJqXoOj2Pvs-LagT9Fbdexa1z3Porbg1Zc7x2XjS9a38U3_lmgK2AlFvDi4u_vv7X9RP2Y4j9</recordid><startdate>20160901</startdate><enddate>20160901</enddate><creator>Kim, Seo Ki</creator><creator>Park, Inhye</creator><creator>Woo, Jung-Woo</creator><creator>Lee, Jun Ho</creator><creator>Choe, Jun-Ho</creator><creator>Kim, Jung-Han</creator><creator>Kim, Jee Soo</creator><general>Springer International Publishing</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TO</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope></search><sort><creationdate>20160901</creationdate><title>Predictive Factors for Lymph Node Metastasis in Papillary Thyroid Microcarcinoma</title><author>Kim, Seo Ki ; Park, Inhye ; Woo, Jung-Woo ; Lee, Jun Ho ; Choe, Jun-Ho ; Kim, Jung-Han ; Kim, Jee Soo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c372t-a1b0a80312299d08294bb8149695db1d01eb8482e8b32ff38a7011bc2ad94c5c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Adult</topic><topic>Age Factors</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Carcinoma, Papillary - secondary</topic><topic>Carcinoma, Papillary - surgery</topic><topic>Endocrine Tumors</topic><topic>Female</topic><topic>Hashimoto Disease - complications</topic><topic>Humans</topic><topic>Lymph Nodes - pathology</topic><topic>Lymph Nodes - surgery</topic><topic>Lymphatic Metastasis</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Neck Dissection</topic><topic>Neoplasm Invasiveness</topic><topic>Neoplasm Recurrence, Local - pathology</topic><topic>Neoplasms, Multiple Primary - secondary</topic><topic>Neoplasms, Multiple Primary - surgery</topic><topic>Oncology</topic><topic>Retrospective Studies</topic><topic>Risk Factors</topic><topic>Sex Factors</topic><topic>Surgery</topic><topic>Surgical Oncology</topic><topic>Thyroid Neoplasms - pathology</topic><topic>Thyroid Neoplasms - surgery</topic><topic>Thyroidectomy</topic><topic>Tumor Burden</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kim, Seo Ki</creatorcontrib><creatorcontrib>Park, Inhye</creatorcontrib><creatorcontrib>Woo, Jung-Woo</creatorcontrib><creatorcontrib>Lee, Jun Ho</creatorcontrib><creatorcontrib>Choe, Jun-Ho</creatorcontrib><creatorcontrib>Kim, Jung-Han</creatorcontrib><creatorcontrib>Kim, Jee Soo</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><jtitle>Annals of surgical oncology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kim, Seo Ki</au><au>Park, Inhye</au><au>Woo, Jung-Woo</au><au>Lee, Jun Ho</au><au>Choe, Jun-Ho</au><au>Kim, Jung-Han</au><au>Kim, Jee Soo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Predictive Factors for Lymph Node Metastasis in Papillary Thyroid Microcarcinoma</atitle><jtitle>Annals of surgical oncology</jtitle><stitle>Ann Surg Oncol</stitle><addtitle>Ann Surg Oncol</addtitle><date>2016-09-01</date><risdate>2016</risdate><volume>23</volume><issue>9</issue><spage>2866</spage><epage>2873</epage><pages>2866-2873</pages><issn>1068-9265</issn><eissn>1534-4681</eissn><abstract>Background
Because lymph node (LN) metastasis has been proven to be a predictor for locoregional recurrence (LRR) in papillary thyroid microcarcinoma (PTMC), better knowledge about the predictors for LN metastasis in PTMC is required.
Methods
We retrospectively reviewed 5656 PTMC patients who underwent total thyroidectomy and central neck dissection and/or lateral neck dissection between January 1997 and June 2015.
Results
Male gender (adjusted odds ratio [OR] 2.332), conventional variant (adjusted OR 4.266), tumor size >0.5 cm (adjusted OR 1.753), multiplicity (adjusted OR 1.168), bilaterality (adjusted OR 1.177), and extrathyroidal extension (ETE) (adjusted OR 1.448) were independent predictors for high prevalence of central LN metastasis (CLNM), whereas per 10-year age increment (adjusted OR 0.760) and chronic lymphocytic thyroiditis (adjusted OR 0.791) were independent predictors for low prevalence of CLNM. In addition, male gender (adjusted OR 1.489), tumor size >0.5 cm (adjusted OR 1.295), multiplicity (adjusted OR 1.801), ETE (adjusted OR 1.659), and CLNM (adjusted OR 4.359) were independent predictors for high prevalence of lateral LN metastasis (LLNM), whereas per 10-year age increment (adjusted OR 0.838) was an independent predictor for low prevalence of LLNM. There was a statistically significant difference in LRR with regard to nodal stage (
p
< 0.001).
Conclusions
Meticulous perioperative evaluation of LN metastasis is required for PTMC patients with the above predictors.</abstract><cop>Cham</cop><pub>Springer International Publishing</pub><pmid>27075321</pmid><doi>10.1245/s10434-016-5225-0</doi><tpages>8</tpages></addata></record> |
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| ispartof | Annals of surgical oncology, 2016-09, Vol.23 (9), p.2866-2873 |
| issn | 1068-9265 1534-4681 |
| language | eng |
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| subjects | Adult Age Factors Aged Aged, 80 and over Carcinoma, Papillary - secondary Carcinoma, Papillary - surgery Endocrine Tumors Female Hashimoto Disease - complications Humans Lymph Nodes - pathology Lymph Nodes - surgery Lymphatic Metastasis Male Medicine Medicine & Public Health Middle Aged Neck Dissection Neoplasm Invasiveness Neoplasm Recurrence, Local - pathology Neoplasms, Multiple Primary - secondary Neoplasms, Multiple Primary - surgery Oncology Retrospective Studies Risk Factors Sex Factors Surgery Surgical Oncology Thyroid Neoplasms - pathology Thyroid Neoplasms - surgery Thyroidectomy Tumor Burden Young Adult |
| title | Predictive Factors for Lymph Node Metastasis in Papillary Thyroid Microcarcinoma |
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