AFAP-1L1-mediated actin filaments crosslinks hinder Trypanosoma cruzi cell invasion and intracellular multiplication
Knocking-down AFAP-1L1 increased Trypanosoma cruzi cell invasion and intracellular multiplication. Thus, we have shown that the integrity of the machinery formed by AFAP-1L1 in actin cytoskeleton polymerization is important to hinder parasite infection. [Display omitted] •AFAP-1L1 forms a physical b...
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| Veröffentlicht in: | Acta tropica 2016-10, Vol.162, p.167-170 |
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| creator | de Araújo, Karine Canuto Loureiro Teixeira, Thaise Lara Machado, Fabrício Castro da Silva, Aline Alves Quintal, Amanda Pifano Neto da Silva, Claudio Vieira |
| description | Knocking-down AFAP-1L1 increased Trypanosoma cruzi cell invasion and intracellular multiplication. Thus, we have shown that the integrity of the machinery formed by AFAP-1L1 in actin cytoskeleton polymerization is important to hinder parasite infection.
[Display omitted]
•AFAP-1L1 forms a physical barrier to Trypanosoma cruzi cell invasion and intracellular multiplication.•Knocking-down AFAP-1L1 induces softening of actin filaments.•Knocking-down AFAP-1L1 facilitates T. cruzi cell invasion and intracellular multiplication.
Host actin cytoskeleton polymerization has been shown to play an important role during Trypanosoma cruzi internalization into mammalian cell. The structure and dynamics of the actin cytoskeleton in cells are regulated by a vast number of actin-binding proteins. Here we aimed to verify the impact of AFAP-1L1, during invasion and multiplication of T. cruzi. Knocking-down AFAP-1L1 increased parasite cell invasion and intracellular multiplication. Thus, we have shown that the integrity of the machinery formed by AFAP-1L1 in actin cytoskeleton polymerization is important to hinder parasite infection. |
| doi_str_mv | 10.1016/j.actatropica.2016.06.028 |
| format | Article |
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[Display omitted]
•AFAP-1L1 forms a physical barrier to Trypanosoma cruzi cell invasion and intracellular multiplication.•Knocking-down AFAP-1L1 induces softening of actin filaments.•Knocking-down AFAP-1L1 facilitates T. cruzi cell invasion and intracellular multiplication.
Host actin cytoskeleton polymerization has been shown to play an important role during Trypanosoma cruzi internalization into mammalian cell. The structure and dynamics of the actin cytoskeleton in cells are regulated by a vast number of actin-binding proteins. Here we aimed to verify the impact of AFAP-1L1, during invasion and multiplication of T. cruzi. Knocking-down AFAP-1L1 increased parasite cell invasion and intracellular multiplication. Thus, we have shown that the integrity of the machinery formed by AFAP-1L1 in actin cytoskeleton polymerization is important to hinder parasite infection.</description><identifier>ISSN: 0001-706X</identifier><identifier>EISSN: 1873-6254</identifier><identifier>DOI: 10.1016/j.actatropica.2016.06.028</identifier><identifier>PMID: 27349187</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Actin cytoskeleton ; Actin Cytoskeleton - metabolism ; Adaptor Proteins, Signal Transducing - pharmacology ; AFAP-1L1 ; Animals ; Cell invasion ; Chagas Disease - parasitology ; Cytoplasm - metabolism ; Female ; Humans ; Male ; Mice ; Mice, Inbred C57BL ; Microfilament Proteins - metabolism ; Microfilament Proteins - pharmacology ; Multiplication ; Trypanosoma cruzi ; Trypanosoma cruzi - drug effects ; Trypanosoma cruzi - metabolism</subject><ispartof>Acta tropica, 2016-10, Vol.162, p.167-170</ispartof><rights>2016 Elsevier B.V.</rights><rights>Copyright © 2016 Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c428t-6a9b4c939e1863b71523f326aa660a017e94665c28f7b14b70f42059902a2143</citedby><cites>FETCH-LOGICAL-c428t-6a9b4c939e1863b71523f326aa660a017e94665c28f7b14b70f42059902a2143</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0001706X16304260$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27349187$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>de Araújo, Karine Canuto Loureiro</creatorcontrib><creatorcontrib>Teixeira, Thaise Lara</creatorcontrib><creatorcontrib>Machado, Fabrício Castro</creatorcontrib><creatorcontrib>da Silva, Aline Alves</creatorcontrib><creatorcontrib>Quintal, Amanda Pifano Neto</creatorcontrib><creatorcontrib>da Silva, Claudio Vieira</creatorcontrib><title>AFAP-1L1-mediated actin filaments crosslinks hinder Trypanosoma cruzi cell invasion and intracellular multiplication</title><title>Acta tropica</title><addtitle>Acta Trop</addtitle><description>Knocking-down AFAP-1L1 increased Trypanosoma cruzi cell invasion and intracellular multiplication. Thus, we have shown that the integrity of the machinery formed by AFAP-1L1 in actin cytoskeleton polymerization is important to hinder parasite infection.
[Display omitted]
•AFAP-1L1 forms a physical barrier to Trypanosoma cruzi cell invasion and intracellular multiplication.•Knocking-down AFAP-1L1 induces softening of actin filaments.•Knocking-down AFAP-1L1 facilitates T. cruzi cell invasion and intracellular multiplication.
Host actin cytoskeleton polymerization has been shown to play an important role during Trypanosoma cruzi internalization into mammalian cell. The structure and dynamics of the actin cytoskeleton in cells are regulated by a vast number of actin-binding proteins. Here we aimed to verify the impact of AFAP-1L1, during invasion and multiplication of T. cruzi. Knocking-down AFAP-1L1 increased parasite cell invasion and intracellular multiplication. Thus, we have shown that the integrity of the machinery formed by AFAP-1L1 in actin cytoskeleton polymerization is important to hinder parasite infection.</description><subject>Actin cytoskeleton</subject><subject>Actin Cytoskeleton - metabolism</subject><subject>Adaptor Proteins, Signal Transducing - pharmacology</subject><subject>AFAP-1L1</subject><subject>Animals</subject><subject>Cell invasion</subject><subject>Chagas Disease - parasitology</subject><subject>Cytoplasm - metabolism</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Mice</subject><subject>Mice, Inbred C57BL</subject><subject>Microfilament Proteins - metabolism</subject><subject>Microfilament Proteins - pharmacology</subject><subject>Multiplication</subject><subject>Trypanosoma cruzi</subject><subject>Trypanosoma cruzi - drug effects</subject><subject>Trypanosoma cruzi - metabolism</subject><issn>0001-706X</issn><issn>1873-6254</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkE1r3DAQhkVISLZp_0JQb7l4O5Jt2TouSz4KC81hD72JsSwTbWzZkeRA-usjd5PSY2BgmJlnvl5CvjNYM2Dix2GNOmL042Q1rnlKrSEZr0_IitVVngleFqdkBQAsq0D8viBfQjikiFclPycXvMoLmcgViZvbzUPGdiwbTGsxmpam2dbRzvY4GBcD1X4MobfuKdBH61rj6d6_TujGMA6YqvMfS7Xpe2rdCwY7OoquTUH0uKTnHj0d5j7aqU_nxgR8JWcd9sF8e_eXZH97s9_eZ7tfdz-3m12mC17HTKBsCi1zaVgt8qZiJc-7nAtEIQCBVUYWQpSa113VsKKpoCs4lFICR86K_JJcH8dOfnyeTYhqsGE5CZ0Z56BYDVIAg3pB5RH9-6w3nZq8HdC_KgZq0Vwd1H-aq0VzBcl4nXqv3tfMTRLxX-eHyAnYHgGTfn2xxqugrXE6Ce6Njqod7SfWvAFKEZnB</recordid><startdate>201610</startdate><enddate>201610</enddate><creator>de Araújo, Karine Canuto Loureiro</creator><creator>Teixeira, Thaise Lara</creator><creator>Machado, Fabrício Castro</creator><creator>da Silva, Aline Alves</creator><creator>Quintal, Amanda Pifano Neto</creator><creator>da Silva, Claudio Vieira</creator><general>Elsevier B.V</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201610</creationdate><title>AFAP-1L1-mediated actin filaments crosslinks hinder Trypanosoma cruzi cell invasion and intracellular multiplication</title><author>de Araújo, Karine Canuto Loureiro ; Teixeira, Thaise Lara ; Machado, Fabrício Castro ; da Silva, Aline Alves ; Quintal, Amanda Pifano Neto ; da Silva, Claudio Vieira</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c428t-6a9b4c939e1863b71523f326aa660a017e94665c28f7b14b70f42059902a2143</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Actin cytoskeleton</topic><topic>Actin Cytoskeleton - metabolism</topic><topic>Adaptor Proteins, Signal Transducing - pharmacology</topic><topic>AFAP-1L1</topic><topic>Animals</topic><topic>Cell invasion</topic><topic>Chagas Disease - parasitology</topic><topic>Cytoplasm - metabolism</topic><topic>Female</topic><topic>Humans</topic><topic>Male</topic><topic>Mice</topic><topic>Mice, Inbred C57BL</topic><topic>Microfilament Proteins - metabolism</topic><topic>Microfilament Proteins - pharmacology</topic><topic>Multiplication</topic><topic>Trypanosoma cruzi</topic><topic>Trypanosoma cruzi - drug effects</topic><topic>Trypanosoma cruzi - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>de Araújo, Karine Canuto Loureiro</creatorcontrib><creatorcontrib>Teixeira, Thaise Lara</creatorcontrib><creatorcontrib>Machado, Fabrício Castro</creatorcontrib><creatorcontrib>da Silva, Aline Alves</creatorcontrib><creatorcontrib>Quintal, Amanda Pifano Neto</creatorcontrib><creatorcontrib>da Silva, Claudio Vieira</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Acta tropica</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>de Araújo, Karine Canuto Loureiro</au><au>Teixeira, Thaise Lara</au><au>Machado, Fabrício Castro</au><au>da Silva, Aline Alves</au><au>Quintal, Amanda Pifano Neto</au><au>da Silva, Claudio Vieira</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>AFAP-1L1-mediated actin filaments crosslinks hinder Trypanosoma cruzi cell invasion and intracellular multiplication</atitle><jtitle>Acta tropica</jtitle><addtitle>Acta Trop</addtitle><date>2016-10</date><risdate>2016</risdate><volume>162</volume><spage>167</spage><epage>170</epage><pages>167-170</pages><issn>0001-706X</issn><eissn>1873-6254</eissn><abstract>Knocking-down AFAP-1L1 increased Trypanosoma cruzi cell invasion and intracellular multiplication. Thus, we have shown that the integrity of the machinery formed by AFAP-1L1 in actin cytoskeleton polymerization is important to hinder parasite infection.
[Display omitted]
•AFAP-1L1 forms a physical barrier to Trypanosoma cruzi cell invasion and intracellular multiplication.•Knocking-down AFAP-1L1 induces softening of actin filaments.•Knocking-down AFAP-1L1 facilitates T. cruzi cell invasion and intracellular multiplication.
Host actin cytoskeleton polymerization has been shown to play an important role during Trypanosoma cruzi internalization into mammalian cell. The structure and dynamics of the actin cytoskeleton in cells are regulated by a vast number of actin-binding proteins. Here we aimed to verify the impact of AFAP-1L1, during invasion and multiplication of T. cruzi. Knocking-down AFAP-1L1 increased parasite cell invasion and intracellular multiplication. Thus, we have shown that the integrity of the machinery formed by AFAP-1L1 in actin cytoskeleton polymerization is important to hinder parasite infection.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>27349187</pmid><doi>10.1016/j.actatropica.2016.06.028</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Actin cytoskeleton Actin Cytoskeleton - metabolism Adaptor Proteins, Signal Transducing - pharmacology AFAP-1L1 Animals Cell invasion Chagas Disease - parasitology Cytoplasm - metabolism Female Humans Male Mice Mice, Inbred C57BL Microfilament Proteins - metabolism Microfilament Proteins - pharmacology Multiplication Trypanosoma cruzi Trypanosoma cruzi - drug effects Trypanosoma cruzi - metabolism |
| title | AFAP-1L1-mediated actin filaments crosslinks hinder Trypanosoma cruzi cell invasion and intracellular multiplication |
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