High prevalence of anti-hepatitis E virus antibodies among blood donors in central Italy, February to March 2014
Prevalence of anti-hepatitis E virus (HEV) antibodies is highly variable in developed countries, which seems partly due to differences in assay sensitivity. Using validated sensitive assays, we tested 313 blood donors attending a hospital transfusion unit in central Italy in January and February 201...
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| Veröffentlicht in: | Euro surveillance : bulletin européen sur les maladies transmissibles 2016-07, Vol.21 (30), p.1 |
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| creator | Lucarelli, Claudia Spada, Enea Taliani, Gloria Chionne, Paola Madonna, Elisabetta Marcantonio, Cinzia Pezzotti, Patrizio Bruni, Roberto La Rosa, Giuseppina Pisani, Giulio Dell'Orso, Luigi Ragone, Katia Tomei, Carla Ciccaglione, Anna Rita |
| description | Prevalence of anti-hepatitis E virus (HEV) antibodies is highly variable in developed countries, which seems partly due to differences in assay sensitivity. Using validated sensitive assays, we tested 313 blood donors attending a hospital transfusion unit in central Italy in January and February 2014 for anti-HEV IgG and IgM and HEV RNA. Data on HEV exposure were collected from all donors. Overall anti-HEV IgG prevalence was 49% (153/313). Eating raw dried pig-liver sausage was the only independent predictor of HEV infection (adjusted prevalence rate ratio = 2.14; 95% confidence interval: 1.23-3.74). Three donors were positive for either anti-HEV IgM (n = 2; 0.6%) or HEV RNA (n = 2; 0.6%); they were completely asymptomatic, without alanine aminotransferase (ALT) abnormalities. Of the two HEV RNA-positive donors (both harbouring genotype 3), one was anti-HEV IgG- and IgM-positive, the other was anti-HEV IgG- and IgM-negative. The third donor was positive for anti-HEV IgG and IgM but HEV RNA-negative. HEV infection is therefore hyperendemic among blood donors (80% men 18-64 years-old) from central Italy and associated with local dietary habits. Nearly 1% of donors have acute or recent infection, implying potential transmission to blood recipients. Neither ALT nor anti-HEV IgM testing seems useful to prevent transfusion-transmitted HEV infection. |
| doi_str_mv | 10.2807/1560-7917.ES.2016.21.30.30299 |
| format | Article |
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Using validated sensitive assays, we tested 313 blood donors attending a hospital transfusion unit in central Italy in January and February 2014 for anti-HEV IgG and IgM and HEV RNA. Data on HEV exposure were collected from all donors. Overall anti-HEV IgG prevalence was 49% (153/313). Eating raw dried pig-liver sausage was the only independent predictor of HEV infection (adjusted prevalence rate ratio = 2.14; 95% confidence interval: 1.23-3.74). Three donors were positive for either anti-HEV IgM (n = 2; 0.6%) or HEV RNA (n = 2; 0.6%); they were completely asymptomatic, without alanine aminotransferase (ALT) abnormalities. Of the two HEV RNA-positive donors (both harbouring genotype 3), one was anti-HEV IgG- and IgM-positive, the other was anti-HEV IgG- and IgM-negative. The third donor was positive for anti-HEV IgG and IgM but HEV RNA-negative. HEV infection is therefore hyperendemic among blood donors (80% men 18-64 years-old) from central Italy and associated with local dietary habits. Nearly 1% of donors have acute or recent infection, implying potential transmission to blood recipients. Neither ALT nor anti-HEV IgM testing seems useful to prevent transfusion-transmitted HEV infection.</description><identifier>ISSN: 1560-7917</identifier><identifier>ISSN: 1025-496X</identifier><identifier>EISSN: 1560-7917</identifier><identifier>DOI: 10.2807/1560-7917.ES.2016.21.30.30299</identifier><identifier>PMID: 27494608</identifier><language>eng</language><publisher>Sweden: Centre Europeen pour la Surveillance Epidemiologique du SIDA (European Centre for the Epidemiological Monitoring of AIDS)</publisher><subject>Adolescent ; Adult ; Aged ; Blood & organ donations ; Blood Donors ; Blood Transfusion ; Confidence intervals ; Female ; Genotype ; Hepatitis ; Hepatitis Antibodies - blood ; Hepatitis E - blood ; Hepatitis E - epidemiology ; Hepatitis E - transmission ; Hepatitis E virus - classification ; Hepatitis E virus - genetics ; Hepatitis E virus - immunology ; Humans ; Immunoglobulin G - blood ; Immunoglobulin M - blood ; Italy - epidemiology ; Male ; Middle Aged ; Molecular Sequence Data ; Prevalence ; Reverse Transcriptase Polymerase Chain Reaction ; Ribonucleic acid ; Risk Factors ; RNA ; RNA, Viral - blood ; RNA, Viral - genetics ; Sequence Analysis, DNA ; Young Adult</subject><ispartof>Euro surveillance : bulletin européen sur les maladies transmissibles, 2016-07, Vol.21 (30), p.1</ispartof><rights>This article is copyright of The Authors, 2016.</rights><rights>Copyright Centre Europeen pour la Surveillance Epidemiologique du SIDA (European Centre for the Epidemiological Monitoring of AIDS) Jul 28, 2016</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c538t-62d0b5d4d03ba72c4e1a67b8aa8343f3ee1e7e2f055a453be750a0be9bc78d2b3</citedby><cites>FETCH-LOGICAL-c538t-62d0b5d4d03ba72c4e1a67b8aa8343f3ee1e7e2f055a453be750a0be9bc78d2b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,860,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27494608$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lucarelli, Claudia</creatorcontrib><creatorcontrib>Spada, Enea</creatorcontrib><creatorcontrib>Taliani, Gloria</creatorcontrib><creatorcontrib>Chionne, Paola</creatorcontrib><creatorcontrib>Madonna, Elisabetta</creatorcontrib><creatorcontrib>Marcantonio, Cinzia</creatorcontrib><creatorcontrib>Pezzotti, Patrizio</creatorcontrib><creatorcontrib>Bruni, Roberto</creatorcontrib><creatorcontrib>La Rosa, Giuseppina</creatorcontrib><creatorcontrib>Pisani, Giulio</creatorcontrib><creatorcontrib>Dell'Orso, Luigi</creatorcontrib><creatorcontrib>Ragone, Katia</creatorcontrib><creatorcontrib>Tomei, Carla</creatorcontrib><creatorcontrib>Ciccaglione, Anna Rita</creatorcontrib><title>High prevalence of anti-hepatitis E virus antibodies among blood donors in central Italy, February to March 2014</title><title>Euro surveillance : bulletin européen sur les maladies transmissibles</title><addtitle>Euro Surveill</addtitle><description>Prevalence of anti-hepatitis E virus (HEV) antibodies is highly variable in developed countries, which seems partly due to differences in assay sensitivity. Using validated sensitive assays, we tested 313 blood donors attending a hospital transfusion unit in central Italy in January and February 2014 for anti-HEV IgG and IgM and HEV RNA. Data on HEV exposure were collected from all donors. Overall anti-HEV IgG prevalence was 49% (153/313). Eating raw dried pig-liver sausage was the only independent predictor of HEV infection (adjusted prevalence rate ratio = 2.14; 95% confidence interval: 1.23-3.74). Three donors were positive for either anti-HEV IgM (n = 2; 0.6%) or HEV RNA (n = 2; 0.6%); they were completely asymptomatic, without alanine aminotransferase (ALT) abnormalities. Of the two HEV RNA-positive donors (both harbouring genotype 3), one was anti-HEV IgG- and IgM-positive, the other was anti-HEV IgG- and IgM-negative. The third donor was positive for anti-HEV IgG and IgM but HEV RNA-negative. HEV infection is therefore hyperendemic among blood donors (80% men 18-64 years-old) from central Italy and associated with local dietary habits. Nearly 1% of donors have acute or recent infection, implying potential transmission to blood recipients. Neither ALT nor anti-HEV IgM testing seems useful to prevent transfusion-transmitted HEV infection.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Blood & organ donations</subject><subject>Blood Donors</subject><subject>Blood Transfusion</subject><subject>Confidence intervals</subject><subject>Female</subject><subject>Genotype</subject><subject>Hepatitis</subject><subject>Hepatitis Antibodies - blood</subject><subject>Hepatitis E - blood</subject><subject>Hepatitis E - epidemiology</subject><subject>Hepatitis E - transmission</subject><subject>Hepatitis E virus - classification</subject><subject>Hepatitis E virus - genetics</subject><subject>Hepatitis E virus - immunology</subject><subject>Humans</subject><subject>Immunoglobulin G - blood</subject><subject>Immunoglobulin M - blood</subject><subject>Italy - epidemiology</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Molecular Sequence Data</subject><subject>Prevalence</subject><subject>Reverse Transcriptase Polymerase Chain Reaction</subject><subject>Ribonucleic acid</subject><subject>Risk Factors</subject><subject>RNA</subject><subject>RNA, Viral - blood</subject><subject>RNA, Viral - genetics</subject><subject>Sequence Analysis, DNA</subject><subject>Young Adult</subject><issn>1560-7917</issn><issn>1025-496X</issn><issn>1560-7917</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkV1L5TAQhsPisrquf0ECInixrZOPNumFFyLHVXDxwvU6JO3UE-lpatIK_ntz1JVlYWCG5JnJm3kJOWZQcg3qlFU1FKphqlzdlRxYXXJWCsjBm-YL2fu83_mn3iXfU3oEkAIa_o3sciUbWYPeI9OVf1jTKeKzHXBskYae2nH2xRonO_vZJ7qizz4u6e3Yhc5jLjdhfKBuCKGjXRhDTNSPtMVxjnag17MdXn7SS3RxsfGFzoH-trFd0yxX_iBfezskPPjI--T-cvXn4qq4uf11fXF-U7SV0HNR8w5c1ckOhLOKtxKZrZXT1mohRS8QGSrkPVSVlZVwqCqw4LBxrdIdd2KfnLzPnWJ4WjDNZuNTi8NgRwxLMkxDUwNoxTJ69B_6GJY4ZnWZYlzyqm50ps7eqTaGlCL2Zop-k_9nGJitNWa7brNdt1ndma01hjMjwLxZk_sPP15Z3Aa7z-6_XohX_12KWw</recordid><startdate>20160728</startdate><enddate>20160728</enddate><creator>Lucarelli, Claudia</creator><creator>Spada, Enea</creator><creator>Taliani, Gloria</creator><creator>Chionne, Paola</creator><creator>Madonna, Elisabetta</creator><creator>Marcantonio, Cinzia</creator><creator>Pezzotti, Patrizio</creator><creator>Bruni, Roberto</creator><creator>La Rosa, Giuseppina</creator><creator>Pisani, Giulio</creator><creator>Dell'Orso, Luigi</creator><creator>Ragone, Katia</creator><creator>Tomei, Carla</creator><creator>Ciccaglione, Anna Rita</creator><general>Centre Europeen pour la Surveillance Epidemiologique du SIDA (European Centre for the Epidemiological Monitoring of AIDS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20160728</creationdate><title>High prevalence of anti-hepatitis E virus antibodies among blood donors in central Italy, February to March 2014</title><author>Lucarelli, Claudia ; Spada, Enea ; Taliani, Gloria ; Chionne, Paola ; Madonna, Elisabetta ; Marcantonio, Cinzia ; Pezzotti, Patrizio ; Bruni, Roberto ; La Rosa, Giuseppina ; Pisani, Giulio ; Dell'Orso, Luigi ; Ragone, Katia ; Tomei, Carla ; Ciccaglione, Anna Rita</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c538t-62d0b5d4d03ba72c4e1a67b8aa8343f3ee1e7e2f055a453be750a0be9bc78d2b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Blood & organ donations</topic><topic>Blood Donors</topic><topic>Blood Transfusion</topic><topic>Confidence intervals</topic><topic>Female</topic><topic>Genotype</topic><topic>Hepatitis</topic><topic>Hepatitis Antibodies - blood</topic><topic>Hepatitis E - blood</topic><topic>Hepatitis E - epidemiology</topic><topic>Hepatitis E - transmission</topic><topic>Hepatitis E virus - classification</topic><topic>Hepatitis E virus - genetics</topic><topic>Hepatitis E virus - immunology</topic><topic>Humans</topic><topic>Immunoglobulin G - blood</topic><topic>Immunoglobulin M - blood</topic><topic>Italy - epidemiology</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Molecular Sequence Data</topic><topic>Prevalence</topic><topic>Reverse Transcriptase Polymerase Chain Reaction</topic><topic>Ribonucleic acid</topic><topic>Risk Factors</topic><topic>RNA</topic><topic>RNA, Viral - blood</topic><topic>RNA, Viral - genetics</topic><topic>Sequence Analysis, DNA</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lucarelli, Claudia</creatorcontrib><creatorcontrib>Spada, Enea</creatorcontrib><creatorcontrib>Taliani, Gloria</creatorcontrib><creatorcontrib>Chionne, Paola</creatorcontrib><creatorcontrib>Madonna, Elisabetta</creatorcontrib><creatorcontrib>Marcantonio, Cinzia</creatorcontrib><creatorcontrib>Pezzotti, Patrizio</creatorcontrib><creatorcontrib>Bruni, Roberto</creatorcontrib><creatorcontrib>La Rosa, Giuseppina</creatorcontrib><creatorcontrib>Pisani, Giulio</creatorcontrib><creatorcontrib>Dell'Orso, Luigi</creatorcontrib><creatorcontrib>Ragone, Katia</creatorcontrib><creatorcontrib>Tomei, Carla</creatorcontrib><creatorcontrib>Ciccaglione, Anna Rita</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Euro surveillance : bulletin européen sur les maladies transmissibles</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lucarelli, Claudia</au><au>Spada, Enea</au><au>Taliani, Gloria</au><au>Chionne, Paola</au><au>Madonna, Elisabetta</au><au>Marcantonio, Cinzia</au><au>Pezzotti, Patrizio</au><au>Bruni, Roberto</au><au>La Rosa, Giuseppina</au><au>Pisani, Giulio</au><au>Dell'Orso, Luigi</au><au>Ragone, Katia</au><au>Tomei, Carla</au><au>Ciccaglione, Anna Rita</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>High prevalence of anti-hepatitis E virus antibodies among blood donors in central Italy, February to March 2014</atitle><jtitle>Euro surveillance : bulletin européen sur les maladies transmissibles</jtitle><addtitle>Euro Surveill</addtitle><date>2016-07-28</date><risdate>2016</risdate><volume>21</volume><issue>30</issue><spage>1</spage><pages>1-</pages><issn>1560-7917</issn><issn>1025-496X</issn><eissn>1560-7917</eissn><abstract>Prevalence of anti-hepatitis E virus (HEV) antibodies is highly variable in developed countries, which seems partly due to differences in assay sensitivity. Using validated sensitive assays, we tested 313 blood donors attending a hospital transfusion unit in central Italy in January and February 2014 for anti-HEV IgG and IgM and HEV RNA. Data on HEV exposure were collected from all donors. Overall anti-HEV IgG prevalence was 49% (153/313). Eating raw dried pig-liver sausage was the only independent predictor of HEV infection (adjusted prevalence rate ratio = 2.14; 95% confidence interval: 1.23-3.74). Three donors were positive for either anti-HEV IgM (n = 2; 0.6%) or HEV RNA (n = 2; 0.6%); they were completely asymptomatic, without alanine aminotransferase (ALT) abnormalities. Of the two HEV RNA-positive donors (both harbouring genotype 3), one was anti-HEV IgG- and IgM-positive, the other was anti-HEV IgG- and IgM-negative. The third donor was positive for anti-HEV IgG and IgM but HEV RNA-negative. HEV infection is therefore hyperendemic among blood donors (80% men 18-64 years-old) from central Italy and associated with local dietary habits. Nearly 1% of donors have acute or recent infection, implying potential transmission to blood recipients. Neither ALT nor anti-HEV IgM testing seems useful to prevent transfusion-transmitted HEV infection.</abstract><cop>Sweden</cop><pub>Centre Europeen pour la Surveillance Epidemiologique du SIDA (European Centre for the Epidemiological Monitoring of AIDS)</pub><pmid>27494608</pmid><doi>10.2807/1560-7917.ES.2016.21.30.30299</doi><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central |
| subjects | Adolescent Adult Aged Blood & organ donations Blood Donors Blood Transfusion Confidence intervals Female Genotype Hepatitis Hepatitis Antibodies - blood Hepatitis E - blood Hepatitis E - epidemiology Hepatitis E - transmission Hepatitis E virus - classification Hepatitis E virus - genetics Hepatitis E virus - immunology Humans Immunoglobulin G - blood Immunoglobulin M - blood Italy - epidemiology Male Middle Aged Molecular Sequence Data Prevalence Reverse Transcriptase Polymerase Chain Reaction Ribonucleic acid Risk Factors RNA RNA, Viral - blood RNA, Viral - genetics Sequence Analysis, DNA Young Adult |
| title | High prevalence of anti-hepatitis E virus antibodies among blood donors in central Italy, February to March 2014 |
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