Involvement of MAK-1 and MAK-2 MAP kinases in cell wall integrity in Neurospora crassa

Among three MAPK disruptants of Neurospora crassa, Δmak-1 was sensitive and Δmak-2 was hypersensitive to micafungin, a beta-1,3-glucan synthase inhibitor, than the wild-type or Δos-2 strains. We identified six micafungin-inducible genes that are involved in cell wall integrity (CWI) and found that M...

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Veröffentlicht in:	Bioscience, biotechnology, and biochemistry biotechnology, and biochemistry, 2016-09, Vol.80 (9), p.1843-1852
Hauptverfasser:	Kamei, Masayuki, Yamashita, Kazuhiro, Takahashi, Masakazu, Fukumori, Fumiyasu, Ichiishi, Akihiko, Fujimura, Makoto
Format:	Artikel
Sprache:	eng
Schlagworte:	beta-Glucans - metabolism Cell Wall - enzymology Cell Wall - genetics cell wall integrity Echinocandins - pharmacology Enzyme Inhibitors - pharmacology Fungal Proteins - genetics Gene Expression Regulation, Fungal - drug effects Glucan 1,3-beta-Glucosidase - genetics Hyphae - genetics Lipopeptides - pharmacology MAP kinase MAP Kinase Signaling System - drug effects micafungin Mitogen-Activated Protein Kinase 1 - genetics Neurospora crassa Neurospora crassa - enzymology Neurospora crassa - genetics
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