DNA Immunization with Trypanosoma cruzi HSP70 Fused to the KMP11 Protein Elicits a Cytotoxic and Humoral Immune Response against the Antigen and Leads to Protection

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Veröffentlicht in:	Infection and Immunity 2001-10, Vol.69 (10), p.6558-6563
Hauptverfasser:	PLANELLES, Lourdes, THOMAS, M. Carmen, ALONSO, Carlos, LOPEZ, Manuel C
Format:	Artikel
Sprache:	eng
Schlagworte:	Adjuvants, Immunologic Animals Antibodies, Protozoan - biosynthesis Antibody Formation Artificial Gene Fusion Bacteriology Biological and medical sciences Chagas Disease - immunology Chagas Disease - parasitology Chagas Disease - prevention & control Chlorocebus aethiops COS Cells Disease Models, Animal DNA, Protozoan - immunology Female Fundamental and applied biological sciences. Psychology Fungal and Parasitic Infections Gene Expression Hsp70 gene HSP70 Heat-Shock Proteins - genetics HSP70 Heat-Shock Proteins - immunology Immunoglobulin G - biosynthesis KMP11 gene Membrane Glycoproteins - genetics Membrane Glycoproteins - immunology Mice Mice, Inbred BALB C Mice, Inbred C57BL Microbiology Pathogenicity, virulence, toxins, bacteriocins, pyrogens, host-bacteria relations, miscellaneous strains Protozoan Proteins - genetics Protozoan Proteins - immunology Protozoan Vaccines - immunology T-Lymphocytes, Cytotoxic - immunology Trypanosoma cruzi Trypanosoma cruzi - genetics Trypanosoma cruzi - immunology Vaccination Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies Vaccines, DNA - immunology
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