A Common Mechanism Underlies Vertebrate Calcium Signaling and Drosophila Phototransduction

Drosophila phototransduction is an important model system for studies of inositol lipid signaling. Light excitation in Drosophila photoreceptors depends on phospholipase C, because null mutants of this enzyme do not respond to light. Surprisingly, genetic elimination of the apparently single inosito...

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Veröffentlicht in:	The Journal of neuroscience 2001-04, Vol.21 (8), p.2622-2629
Hauptverfasser:	Chorna-Ornan, Irit, Joel-Almagor, Tamar, Ben-Ami, Hagit Cohen, Frechter, Shahar, Gillo, Boaz, Selinger, Zvi, Gill, Donald L, Minke, Baruch
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Boron Compounds - pharmacology calcium Calcium - metabolism Calcium Channels - metabolism Calcium Signaling - drug effects Calcium Signaling - physiology Calmodulin-Binding Proteins - metabolism Cells, Cultured Chloride Channels - immunology Chloride Channels - metabolism Dose-Response Relationship, Drug Dose-Response Relationship, Radiation Drosophila Drosophila Proteins Electroretinography - drug effects In Vitro Techniques Inositol 1,4,5-Trisphosphate - metabolism Inositol 1,4,5-Trisphosphate - pharmacology Inositol 1,4,5-Trisphosphate Receptors Insect Proteins - metabolism Light Membrane Proteins - metabolism Oocytes - cytology Oocytes - drug effects Oocytes - metabolism Patch-Clamp Techniques phospholipase Photoreceptor Cells, Invertebrate - drug effects Photoreceptor Cells, Invertebrate - metabolism Photoreceptor Cells, Invertebrate - radiation effects Receptors, Cytoplasmic and Nuclear - antagonists & inhibitors Transient Receptor Potential Channels Trp protein Vision, Ocular - drug effects Vision, Ocular - physiology Vision, Ocular - radiation effects Xenopus
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