Preclinical evaluation of docusate as protective agent from herpes simplex viruses

Prevention of sexually transmitted infections (STIs) is key to public health efforts to control these diseases. An effective vaginal microbicide could provide topical, broad-spectrum prevention against the transmission of several STI pathogens. Docusate is a sulfated surfactant and, as such, may ina...

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Veröffentlicht in:	Antiviral research 2001-10, Vol.52 (1), p.25-32
Hauptverfasser:	Gong, Yunhao, Wen, Aimin, Cheung, Dorothy, Wong, Michelle, Sacks, Stephen L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibiotics. Antiinfectious agents. Antiparasitic agents Antiviral agents Biological and medical sciences Cells, Cultured Cercopithecus aethiops Dioctyl Sulfosuccinic Acid - pharmacology Dioctyl Sulfosuccinic Acid - toxicity Docusate Dose-Response Relationship, Drug Herpes simplex virus Herpesvirus 1, Human - drug effects Herpesvirus 1, Human - growth & development Herpesvirus 2, Human - drug effects Herpesvirus 2, Human - growth & development Kinetics Medical sciences Pharmacology. Drug treatments Preclinical evaluation Protective Agents - pharmacology Protective Agents - toxicity Sexually Transmitted Diseases, Viral - prevention & control Simplexvirus - drug effects Sodium Dodecyl Sulfate - pharmacology Sodium Dodecyl Sulfate - toxicity Surface-Active Agents - pharmacology Surface-Active Agents - toxicity Time Factors Vero Cells Viral Plaque Assay Virus Latency - drug effects
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