Quantitative analysis of endogenous compounds

•Quantification of endogenous analytes in biological matrices.•Presents an overview of the four approaches.•Summarize their applications, and compare their advantages and disadvantages.•Discuss validation requirements and compatibility with FDA guidelines. Accurate quantitative analysis of endogenou...

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Veröffentlicht in:	Journal of pharmaceutical and biomedical analysis 2016-09, Vol.128, p.426-437
Hauptverfasser:	Thakare, Rhishikesh, Chhonker, Yashpal S., Gautam, Nagsen, Alamoudi, Jawaher Abdullah, Alnouti, Yazen
Format:	Artikel
Sprache:	eng
Schlagworte:	Background subtraction Biomarker Chemistry Techniques, Analytical - methods Chemistry Techniques, Analytical - standards Chromatography, Liquid - methods Guidelines as Topic LC–MS/MS Standard addition Surrogate analyte Surrogate matrix Tandem Mass Spectrometry - methods United States United States Food and Drug Administration Validation Studies as Topic
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