MicroRNAs as Noninvasive Biomarkers in Bladder Cancer Detection: A Diagnostic Meta-Analysis Based on qRT-PCR Data
Objective As the diagnostic significance of microRNAs (miRNAs) in the detection of bladder cancer is controversial, we aimed to perform a meta-analysis to comprehensively assess the diagnostic value of miRNAs in blood and urine for detecting bladder cancer. Methods A systematic literature search of...
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| Veröffentlicht in: | The International journal of biological markers 2016-07, Vol.31 (3), p.276-285 |
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| container_title | The International journal of biological markers |
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| creator | Xiao, Shuhui Wang, Jinfeng Xiao, Ning |
| description | Objective
As the diagnostic significance of microRNAs (miRNAs) in the detection of bladder cancer is controversial, we aimed to perform a meta-analysis to comprehensively assess the diagnostic value of miRNAs in blood and urine for detecting bladder cancer.
Methods
A systematic literature search of public databases was conducted to obtain qualified studies. Sensitivity was utilized to plot the summary receiver operator characteristic (SROC) curve against specificity and the area under the SROC curve (AUC) was generated to evaluate the pooled diagnostic efficiency. Subgroup analyses and meta-regression were applied to investigate the underlying sources of heterogeneity. The STATA 12.0 software was used to perform all statistic analyses.
Results
A total of 58 studies from 22 articles comprising 4,558 bladder cancer patients and 4,456 controls were included in our meta-analysis. MiRNAs in blood and urine manifested relatively good diagnostic efficiency in detecting bladder cancer, with a sensitivity of 0.74, a specificity of 0.78, and an AUC of 0.83. Multiple-miRNA assays were more accurate than single-miRNA ones in bladder cancer diagnosis. Blood-based miRNA assays displayed better diagnostic performance than urine-based ones. In addition, miRNAs showed reduced diagnostic value in bladder cancer among Caucasians compared with Asians.
Conclusions
MiRNAs in blood and urine, especially the combination of multiple miRNAs, may serve as hopeful noninvasive biomarkers for early diagnosis of bladder cancer. Further extensive prospective research is needed to verify their clinical significance in bladder cancer diagnosis. |
| doi_str_mv | 10.5301/jbm.5000199 |
| format | Article |
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As the diagnostic significance of microRNAs (miRNAs) in the detection of bladder cancer is controversial, we aimed to perform a meta-analysis to comprehensively assess the diagnostic value of miRNAs in blood and urine for detecting bladder cancer.
Methods
A systematic literature search of public databases was conducted to obtain qualified studies. Sensitivity was utilized to plot the summary receiver operator characteristic (SROC) curve against specificity and the area under the SROC curve (AUC) was generated to evaluate the pooled diagnostic efficiency. Subgroup analyses and meta-regression were applied to investigate the underlying sources of heterogeneity. The STATA 12.0 software was used to perform all statistic analyses.
Results
A total of 58 studies from 22 articles comprising 4,558 bladder cancer patients and 4,456 controls were included in our meta-analysis. MiRNAs in blood and urine manifested relatively good diagnostic efficiency in detecting bladder cancer, with a sensitivity of 0.74, a specificity of 0.78, and an AUC of 0.83. Multiple-miRNA assays were more accurate than single-miRNA ones in bladder cancer diagnosis. Blood-based miRNA assays displayed better diagnostic performance than urine-based ones. In addition, miRNAs showed reduced diagnostic value in bladder cancer among Caucasians compared with Asians.
Conclusions
MiRNAs in blood and urine, especially the combination of multiple miRNAs, may serve as hopeful noninvasive biomarkers for early diagnosis of bladder cancer. Further extensive prospective research is needed to verify their clinical significance in bladder cancer diagnosis.</description><identifier>ISSN: 1724-6008</identifier><identifier>ISSN: 0393-6155</identifier><identifier>EISSN: 1724-6008</identifier><identifier>DOI: 10.5301/jbm.5000199</identifier><identifier>PMID: 26954073</identifier><language>eng</language><publisher>London, England: SAGE Publications</publisher><subject>Biomarkers ; Biomarkers, Tumor - blood ; Biomarkers, Tumor - genetics ; Bladder cancer ; Blood ; Cancer ; Diagnosis ; Humans ; Medical diagnosis ; Meta-analysis ; MicroRNAs ; MicroRNAs - blood ; MicroRNAs - genetics ; miRNA ; Neoplasm Invasiveness ; Reverse Transcriptase Polymerase Chain Reaction ; Urinary Bladder Neoplasms - blood ; Urinary Bladder Neoplasms - genetics ; Urinary Bladder Neoplasms - pathology ; Urine</subject><ispartof>The International journal of biological markers, 2016-07, Vol.31 (3), p.276-285</ispartof><rights>2016 SAGE Publications</rights><rights>2016 SAGE Publications. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the associated terms available at: https://uk.sagepub.com/en-gb/eur/reusing-open-access-and-sage-choice-content</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c317t-6689bda7309d835ed8fce5a756693a56509eeab538b3ca6031fa104d6ad8a8f33</citedby><cites>FETCH-LOGICAL-c317t-6689bda7309d835ed8fce5a756693a56509eeab538b3ca6031fa104d6ad8a8f33</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://journals.sagepub.com/doi/pdf/10.5301/jbm.5000199$$EPDF$$P50$$Gsage$$H</linktopdf><linktohtml>$$Uhttps://journals.sagepub.com/doi/10.5301/jbm.5000199$$EHTML$$P50$$Gsage$$H</linktohtml><link.rule.ids>314,776,780,21945,27830,27901,27902,44921,45309</link.rule.ids><linktorsrc>$$Uhttps://journals.sagepub.com/doi/full/10.5301/jbm.5000199?utm_source=summon&utm_medium=discovery-provider$$EView_record_in_SAGE_Publications$$FView_record_in_$$GSAGE_Publications</linktorsrc><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26954073$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Xiao, Shuhui</creatorcontrib><creatorcontrib>Wang, Jinfeng</creatorcontrib><creatorcontrib>Xiao, Ning</creatorcontrib><title>MicroRNAs as Noninvasive Biomarkers in Bladder Cancer Detection: A Diagnostic Meta-Analysis Based on qRT-PCR Data</title><title>The International journal of biological markers</title><addtitle>Int J Biol Markers</addtitle><description>Objective
As the diagnostic significance of microRNAs (miRNAs) in the detection of bladder cancer is controversial, we aimed to perform a meta-analysis to comprehensively assess the diagnostic value of miRNAs in blood and urine for detecting bladder cancer.
Methods
A systematic literature search of public databases was conducted to obtain qualified studies. Sensitivity was utilized to plot the summary receiver operator characteristic (SROC) curve against specificity and the area under the SROC curve (AUC) was generated to evaluate the pooled diagnostic efficiency. Subgroup analyses and meta-regression were applied to investigate the underlying sources of heterogeneity. The STATA 12.0 software was used to perform all statistic analyses.
Results
A total of 58 studies from 22 articles comprising 4,558 bladder cancer patients and 4,456 controls were included in our meta-analysis. MiRNAs in blood and urine manifested relatively good diagnostic efficiency in detecting bladder cancer, with a sensitivity of 0.74, a specificity of 0.78, and an AUC of 0.83. Multiple-miRNA assays were more accurate than single-miRNA ones in bladder cancer diagnosis. Blood-based miRNA assays displayed better diagnostic performance than urine-based ones. In addition, miRNAs showed reduced diagnostic value in bladder cancer among Caucasians compared with Asians.
Conclusions
MiRNAs in blood and urine, especially the combination of multiple miRNAs, may serve as hopeful noninvasive biomarkers for early diagnosis of bladder cancer. Further extensive prospective research is needed to verify their clinical significance in bladder cancer diagnosis.</description><subject>Biomarkers</subject><subject>Biomarkers, Tumor - blood</subject><subject>Biomarkers, Tumor - genetics</subject><subject>Bladder cancer</subject><subject>Blood</subject><subject>Cancer</subject><subject>Diagnosis</subject><subject>Humans</subject><subject>Medical diagnosis</subject><subject>Meta-analysis</subject><subject>MicroRNAs</subject><subject>MicroRNAs - blood</subject><subject>MicroRNAs - genetics</subject><subject>miRNA</subject><subject>Neoplasm Invasiveness</subject><subject>Reverse Transcriptase Polymerase Chain Reaction</subject><subject>Urinary Bladder Neoplasms - blood</subject><subject>Urinary Bladder Neoplasms - genetics</subject><subject>Urinary Bladder Neoplasms - pathology</subject><subject>Urine</subject><issn>1724-6008</issn><issn>0393-6155</issn><issn>1724-6008</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNptkc1P3DAQxa2qCCjtqffKUi-VqsA4jp2E236UDwlotaLnaBJPkLdZm81kkfjvCWKBCnF6c_jpzcx7QnxVcGg0qKNlvTo0AKDK8oPYV3maJRag-PjfvCc-MS8BUgW53RV7qS1NBrneF-tL3_RxcTVhiSyvYvDhDtnfkZz6uML-H_UsfZDTDp2jXs4wNKPMaaBm8DEcy4mce7wJkQffyEsaMJkE7O7Zs5wik5MxyPXiOvkzW8g5DvhZ7LTYMX3Z6oH4e_LrenaWXPw-PZ9NLpJGq3xIrC3K2mGuoXSFNuSKtiGDubG21GisgZIIa6OLWjdoQasWFWTOoiuwaLU-ED-efG_7uN4QD9XKc0Ndh4HihitVQAmZ1Zka0e9v0GXc9OMXXKVZmmmTQ2pH6ucTNQbG3FNb3fZ-jOi-UlA9NlGNTVTbJkb629ZzU6_IvbDP0b_ex3hDrwvf83oA072OsA</recordid><startdate>20160701</startdate><enddate>20160701</enddate><creator>Xiao, Shuhui</creator><creator>Wang, Jinfeng</creator><creator>Xiao, Ning</creator><general>SAGE Publications</general><general>Sage Publications Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7XB</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>KB0</scope><scope>LK8</scope><scope>M7P</scope><scope>NAPCQ</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20160701</creationdate><title>MicroRNAs as Noninvasive Biomarkers in Bladder Cancer Detection: A Diagnostic Meta-Analysis Based on qRT-PCR Data</title><author>Xiao, Shuhui ; Wang, Jinfeng ; Xiao, Ning</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c317t-6689bda7309d835ed8fce5a756693a56509eeab538b3ca6031fa104d6ad8a8f33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Biomarkers</topic><topic>Biomarkers, Tumor - blood</topic><topic>Biomarkers, Tumor - genetics</topic><topic>Bladder cancer</topic><topic>Blood</topic><topic>Cancer</topic><topic>Diagnosis</topic><topic>Humans</topic><topic>Medical diagnosis</topic><topic>Meta-analysis</topic><topic>MicroRNAs</topic><topic>MicroRNAs - blood</topic><topic>MicroRNAs - genetics</topic><topic>miRNA</topic><topic>Neoplasm Invasiveness</topic><topic>Reverse Transcriptase Polymerase Chain Reaction</topic><topic>Urinary Bladder Neoplasms - blood</topic><topic>Urinary Bladder Neoplasms - genetics</topic><topic>Urinary Bladder Neoplasms - pathology</topic><topic>Urine</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Xiao, Shuhui</creatorcontrib><creatorcontrib>Wang, Jinfeng</creatorcontrib><creatorcontrib>Xiao, Ning</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Biological Science Database</collection><collection>Nursing & Allied Health Premium</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>The International journal of biological markers</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>Xiao, Shuhui</au><au>Wang, Jinfeng</au><au>Xiao, Ning</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>MicroRNAs as Noninvasive Biomarkers in Bladder Cancer Detection: A Diagnostic Meta-Analysis Based on qRT-PCR Data</atitle><jtitle>The International journal of biological markers</jtitle><addtitle>Int J Biol Markers</addtitle><date>2016-07-01</date><risdate>2016</risdate><volume>31</volume><issue>3</issue><spage>276</spage><epage>285</epage><pages>276-285</pages><issn>1724-6008</issn><issn>0393-6155</issn><eissn>1724-6008</eissn><abstract>Objective
As the diagnostic significance of microRNAs (miRNAs) in the detection of bladder cancer is controversial, we aimed to perform a meta-analysis to comprehensively assess the diagnostic value of miRNAs in blood and urine for detecting bladder cancer.
Methods
A systematic literature search of public databases was conducted to obtain qualified studies. Sensitivity was utilized to plot the summary receiver operator characteristic (SROC) curve against specificity and the area under the SROC curve (AUC) was generated to evaluate the pooled diagnostic efficiency. Subgroup analyses and meta-regression were applied to investigate the underlying sources of heterogeneity. The STATA 12.0 software was used to perform all statistic analyses.
Results
A total of 58 studies from 22 articles comprising 4,558 bladder cancer patients and 4,456 controls were included in our meta-analysis. MiRNAs in blood and urine manifested relatively good diagnostic efficiency in detecting bladder cancer, with a sensitivity of 0.74, a specificity of 0.78, and an AUC of 0.83. Multiple-miRNA assays were more accurate than single-miRNA ones in bladder cancer diagnosis. Blood-based miRNA assays displayed better diagnostic performance than urine-based ones. In addition, miRNAs showed reduced diagnostic value in bladder cancer among Caucasians compared with Asians.
Conclusions
MiRNAs in blood and urine, especially the combination of multiple miRNAs, may serve as hopeful noninvasive biomarkers for early diagnosis of bladder cancer. Further extensive prospective research is needed to verify their clinical significance in bladder cancer diagnosis.</abstract><cop>London, England</cop><pub>SAGE Publications</pub><pmid>26954073</pmid><doi>10.5301/jbm.5000199</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Biomarkers Biomarkers, Tumor - blood Biomarkers, Tumor - genetics Bladder cancer Blood Cancer Diagnosis Humans Medical diagnosis Meta-analysis MicroRNAs MicroRNAs - blood MicroRNAs - genetics miRNA Neoplasm Invasiveness Reverse Transcriptase Polymerase Chain Reaction Urinary Bladder Neoplasms - blood Urinary Bladder Neoplasms - genetics Urinary Bladder Neoplasms - pathology Urine |
| title | MicroRNAs as Noninvasive Biomarkers in Bladder Cancer Detection: A Diagnostic Meta-Analysis Based on qRT-PCR Data |
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