Increased TEAD4 expression and nuclear localization in colorectal cancer promote epithelial–mesenchymal transition and metastasis in a YAP-independent manner

Dysregulation of the Hippo pathway occurs in a variety of cancers and often correlates with a poor prognosis. To further explore the potential role of Hippo pathway dysregulation in tumor development and progression, we investigated its downstream transcription factor TEAD4 in colorectal cancer (CRC...

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Veröffentlicht in:	Oncogene 2016-05, Vol.35 (21), p.2789-2800
Hauptverfasser:	Liu, Y, Wang, G, Yang, Y, Mei, Z, Liang, Z, Cui, A, Wu, T, Liu, C-Y, Cui, L
Format:	Artikel
Sprache:	eng
Schlagworte:	631/67 631/80 Adaptor Proteins, Signal Transducing - metabolism Animals Apoptosis Apoptosis - physiology Cell adhesion Cell Biology Cell Line, Tumor Cell Nucleus - metabolism Cell Proliferation - physiology Cellular signal transduction Colorectal cancer Colorectal carcinoma Colorectal Neoplasms - metabolism Colorectal Neoplasms - pathology Development and progression DNA microarrays DNA-Binding Proteins - biosynthesis DNA-Binding Proteins - metabolism E-cadherin Epithelial-Mesenchymal Transition Gene expression Gene regulation Genetic aspects Health aspects Heterografts Human Genetics Humans Internal Medicine Localization Male Medical prognosis Medicine Medicine & Public Health Mesenchyme Metastases Metastasis Mice Mice, Nude Mobility Muscle Proteins - biosynthesis Muscle Proteins - metabolism Mutants Neoplasm Metastasis Oncology original-article Phosphoproteins - metabolism Prognosis Properties Protein-Serine-Threonine Kinases - metabolism Transcription factors Transcription Factors - biosynthesis Transcription Factors - metabolism Transcriptional Activation Transcriptomes Transfection Tumor proteins Tumors Vimentin Xenografts Yes-associated protein
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