Longitudinal study on diffusion tensor imaging and diffusion tensor tractography following spinal cord contusion injury in rats
Introduction Diffusion tensor imaging (DTI) as a potential technology has been used in spinal cord injury (SCI) studies, but the longitudinal evaluation of DTI parameters after SCI, and the correlation between DTI parameters and locomotor outcomes need to be defined. Methods Adult Wistar rats ( n =...
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| Veröffentlicht in: | Neuroradiology 2016-06, Vol.58 (6), p.607-614 |
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| creator | Zhao, Can Rao, Jia-Sheng Pei, Xiao-Jiao Lei, Jian-Feng Wang, Zhan-Jing Yang, Zhao-Yang Li, Xiao-Guang |
| description | Introduction
Diffusion tensor imaging (DTI) as a potential technology has been used in spinal cord injury (SCI) studies, but the longitudinal evaluation of DTI parameters after SCI, and the correlation between DTI parameters and locomotor outcomes need to be defined.
Methods
Adult Wistar rats (
n
= 6) underwent traumatic thoracic cord contusion by an NYU impactor. DTI and Basso–Beattie–Bresnahan datasets were collected pre-SCI and 1, 3, 7, 14, and 84 days post-SCI. Diffusion tensor tractography (DTT) of the spinal cord was also generated. Fractional anisotropy (FA) and connection rate of fibers at the injury epicenter and at 5 mm rostral/caudal to the epicenter were calculated. The variations of these parameters after SCI were observed by one-way analysis of variance and the correlations between these parameters and motor function were explored by Pearson’s correlation.
Results
FA at the epicenter decreased most remarkably on day 1 post-SCI (from 0.780 ± 0.012 to 0.330 ± 0.015), and continued to decrease slightly by day 3 post-SCI (0.313 ± 0.015), while other parameters decreased significantly over the first 3 days after SCI. DTT showed residual fibers concentrated on ventral and ventrolateral sides of the cord. Moreover, FA at the epicenter exhibited the strongest correlation (
r
= 0.887,
p
= 0.000) with the locomotion performance.
Conclusion
FA was sensitive to degeneration in white matter and DTT could directly reflect the distribution of the residual white matter. Moreover, days 1 to 3 post-SCI may be the optimal time window for SCI examination and therapy. |
| doi_str_mv | 10.1007/s00234-016-1660-7 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1808740014</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1791333251</sourcerecordid><originalsourceid>FETCH-LOGICAL-c471t-36bdf2e7baa1e62981798af975402c737f8c69f596cd82191fb0c2e0b75f2723</originalsourceid><addsrcrecordid>eNqFkU9r3DAQxUVpSDZ_PkAvwdBLLm5mJFuyjiG0SWEhl9yFLEuuF6-0lWzKnvLVo43TEFpKL5qB95snZh4hnxC-IIC4TgCUVSUgL5FzKMUHssKK0RIlhY9kleWmZLKCE3Ka0gYAmGDimJxQLhmKhq3I0zr4fpjmbvB6LFJu9kXwRTc4N6chd5P1KcRi2Op-8H2hffe3OEVtptBHvfuxL1wYx_DrwKbdi6kJscuPn5aZwW_muM-liHpK5-TI6THZi9d6Rh6_fX28vS_XD3ffb2_WpakETiXjbeeoFa3WaDmVDQrZaCdFXQE1eSnXGC5dLbnpGooSXQuGWmhF7aig7IxcLba7GH7ONk1qOyRjx1F7G-aksIFGVAD5ev9FhUTGGK0xo5__QDdhjnnnFwpqAZzXmcKFMjGkFK1Tu5jPGfcKQR1yVEuOKueoDjkqkWcuX53ndmu7t4nfwWWALkDKku9tfPf1P12fARWrqeE</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1790570665</pqid></control><display><type>article</type><title>Longitudinal study on diffusion tensor imaging and diffusion tensor tractography following spinal cord contusion injury in rats</title><source>MEDLINE</source><source>SpringerLink Journals - AutoHoldings</source><creator>Zhao, Can ; Rao, Jia-Sheng ; Pei, Xiao-Jiao ; Lei, Jian-Feng ; Wang, Zhan-Jing ; Yang, Zhao-Yang ; Li, Xiao-Guang</creator><creatorcontrib>Zhao, Can ; Rao, Jia-Sheng ; Pei, Xiao-Jiao ; Lei, Jian-Feng ; Wang, Zhan-Jing ; Yang, Zhao-Yang ; Li, Xiao-Guang</creatorcontrib><description>Introduction
Diffusion tensor imaging (DTI) as a potential technology has been used in spinal cord injury (SCI) studies, but the longitudinal evaluation of DTI parameters after SCI, and the correlation between DTI parameters and locomotor outcomes need to be defined.
Methods
Adult Wistar rats (
n
= 6) underwent traumatic thoracic cord contusion by an NYU impactor. DTI and Basso–Beattie–Bresnahan datasets were collected pre-SCI and 1, 3, 7, 14, and 84 days post-SCI. Diffusion tensor tractography (DTT) of the spinal cord was also generated. Fractional anisotropy (FA) and connection rate of fibers at the injury epicenter and at 5 mm rostral/caudal to the epicenter were calculated. The variations of these parameters after SCI were observed by one-way analysis of variance and the correlations between these parameters and motor function were explored by Pearson’s correlation.
Results
FA at the epicenter decreased most remarkably on day 1 post-SCI (from 0.780 ± 0.012 to 0.330 ± 0.015), and continued to decrease slightly by day 3 post-SCI (0.313 ± 0.015), while other parameters decreased significantly over the first 3 days after SCI. DTT showed residual fibers concentrated on ventral and ventrolateral sides of the cord. Moreover, FA at the epicenter exhibited the strongest correlation (
r
= 0.887,
p
= 0.000) with the locomotion performance.
Conclusion
FA was sensitive to degeneration in white matter and DTT could directly reflect the distribution of the residual white matter. Moreover, days 1 to 3 post-SCI may be the optimal time window for SCI examination and therapy.</description><identifier>ISSN: 0028-3940</identifier><identifier>EISSN: 1432-1920</identifier><identifier>DOI: 10.1007/s00234-016-1660-7</identifier><identifier>PMID: 26931783</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Aging - pathology ; Animals ; Anisotropy ; Diffusion Tensor Imaging - methods ; Disease Progression ; Female ; Functional Neuroradiology ; Image Interpretation, Computer-Assisted - methods ; Imaging ; Longitudinal Studies ; Medical imaging ; Medicine ; Medicine & Public Health ; Neurology ; Neuroradiology ; Neurosciences ; Neurosurgery ; Radiology ; Rats ; Rats, Wistar ; Reproducibility of Results ; Rodents ; Sensitivity and Specificity ; Severity of Illness Index ; Spinal cord injuries ; Spinal Cord Injuries - diagnostic imaging ; Spinal Cord Injuries - pathology ; Spinal Cord Injuries - physiopathology ; Studies ; Subtraction Technique ; White Matter - diagnostic imaging ; White Matter - pathology ; White Matter - physiopathology</subject><ispartof>Neuroradiology, 2016-06, Vol.58 (6), p.607-614</ispartof><rights>Springer-Verlag Berlin Heidelberg 2016</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c471t-36bdf2e7baa1e62981798af975402c737f8c69f596cd82191fb0c2e0b75f2723</citedby><cites>FETCH-LOGICAL-c471t-36bdf2e7baa1e62981798af975402c737f8c69f596cd82191fb0c2e0b75f2723</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00234-016-1660-7$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00234-016-1660-7$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26931783$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zhao, Can</creatorcontrib><creatorcontrib>Rao, Jia-Sheng</creatorcontrib><creatorcontrib>Pei, Xiao-Jiao</creatorcontrib><creatorcontrib>Lei, Jian-Feng</creatorcontrib><creatorcontrib>Wang, Zhan-Jing</creatorcontrib><creatorcontrib>Yang, Zhao-Yang</creatorcontrib><creatorcontrib>Li, Xiao-Guang</creatorcontrib><title>Longitudinal study on diffusion tensor imaging and diffusion tensor tractography following spinal cord contusion injury in rats</title><title>Neuroradiology</title><addtitle>Neuroradiology</addtitle><addtitle>Neuroradiology</addtitle><description>Introduction
Diffusion tensor imaging (DTI) as a potential technology has been used in spinal cord injury (SCI) studies, but the longitudinal evaluation of DTI parameters after SCI, and the correlation between DTI parameters and locomotor outcomes need to be defined.
Methods
Adult Wistar rats (
n
= 6) underwent traumatic thoracic cord contusion by an NYU impactor. DTI and Basso–Beattie–Bresnahan datasets were collected pre-SCI and 1, 3, 7, 14, and 84 days post-SCI. Diffusion tensor tractography (DTT) of the spinal cord was also generated. Fractional anisotropy (FA) and connection rate of fibers at the injury epicenter and at 5 mm rostral/caudal to the epicenter were calculated. The variations of these parameters after SCI were observed by one-way analysis of variance and the correlations between these parameters and motor function were explored by Pearson’s correlation.
Results
FA at the epicenter decreased most remarkably on day 1 post-SCI (from 0.780 ± 0.012 to 0.330 ± 0.015), and continued to decrease slightly by day 3 post-SCI (0.313 ± 0.015), while other parameters decreased significantly over the first 3 days after SCI. DTT showed residual fibers concentrated on ventral and ventrolateral sides of the cord. Moreover, FA at the epicenter exhibited the strongest correlation (
r
= 0.887,
p
= 0.000) with the locomotion performance.
Conclusion
FA was sensitive to degeneration in white matter and DTT could directly reflect the distribution of the residual white matter. Moreover, days 1 to 3 post-SCI may be the optimal time window for SCI examination and therapy.</description><subject>Aging - pathology</subject><subject>Animals</subject><subject>Anisotropy</subject><subject>Diffusion Tensor Imaging - methods</subject><subject>Disease Progression</subject><subject>Female</subject><subject>Functional Neuroradiology</subject><subject>Image Interpretation, Computer-Assisted - methods</subject><subject>Imaging</subject><subject>Longitudinal Studies</subject><subject>Medical imaging</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Neurology</subject><subject>Neuroradiology</subject><subject>Neurosciences</subject><subject>Neurosurgery</subject><subject>Radiology</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Reproducibility of Results</subject><subject>Rodents</subject><subject>Sensitivity and Specificity</subject><subject>Severity of Illness Index</subject><subject>Spinal cord injuries</subject><subject>Spinal Cord Injuries - diagnostic imaging</subject><subject>Spinal Cord Injuries - pathology</subject><subject>Spinal Cord Injuries - physiopathology</subject><subject>Studies</subject><subject>Subtraction Technique</subject><subject>White Matter - diagnostic imaging</subject><subject>White Matter - pathology</subject><subject>White Matter - physiopathology</subject><issn>0028-3940</issn><issn>1432-1920</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqFkU9r3DAQxUVpSDZ_PkAvwdBLLm5mJFuyjiG0SWEhl9yFLEuuF6-0lWzKnvLVo43TEFpKL5qB95snZh4hnxC-IIC4TgCUVSUgL5FzKMUHssKK0RIlhY9kleWmZLKCE3Ka0gYAmGDimJxQLhmKhq3I0zr4fpjmbvB6LFJu9kXwRTc4N6chd5P1KcRi2Op-8H2hffe3OEVtptBHvfuxL1wYx_DrwKbdi6kJscuPn5aZwW_muM-liHpK5-TI6THZi9d6Rh6_fX28vS_XD3ffb2_WpakETiXjbeeoFa3WaDmVDQrZaCdFXQE1eSnXGC5dLbnpGooSXQuGWmhF7aig7IxcLba7GH7ONk1qOyRjx1F7G-aksIFGVAD5ev9FhUTGGK0xo5__QDdhjnnnFwpqAZzXmcKFMjGkFK1Tu5jPGfcKQR1yVEuOKueoDjkqkWcuX53ndmu7t4nfwWWALkDKku9tfPf1P12fARWrqeE</recordid><startdate>20160601</startdate><enddate>20160601</enddate><creator>Zhao, Can</creator><creator>Rao, Jia-Sheng</creator><creator>Pei, Xiao-Jiao</creator><creator>Lei, Jian-Feng</creator><creator>Wang, Zhan-Jing</creator><creator>Yang, Zhao-Yang</creator><creator>Li, Xiao-Guang</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QO</scope><scope>7RV</scope><scope>7TK</scope><scope>7U7</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>M7P</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20160601</creationdate><title>Longitudinal study on diffusion tensor imaging and diffusion tensor tractography following spinal cord contusion injury in rats</title><author>Zhao, Can ; Rao, Jia-Sheng ; Pei, Xiao-Jiao ; Lei, Jian-Feng ; Wang, Zhan-Jing ; Yang, Zhao-Yang ; Li, Xiao-Guang</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c471t-36bdf2e7baa1e62981798af975402c737f8c69f596cd82191fb0c2e0b75f2723</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Aging - pathology</topic><topic>Animals</topic><topic>Anisotropy</topic><topic>Diffusion Tensor Imaging - methods</topic><topic>Disease Progression</topic><topic>Female</topic><topic>Functional Neuroradiology</topic><topic>Image Interpretation, Computer-Assisted - methods</topic><topic>Imaging</topic><topic>Longitudinal Studies</topic><topic>Medical imaging</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Neurology</topic><topic>Neuroradiology</topic><topic>Neurosciences</topic><topic>Neurosurgery</topic><topic>Radiology</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Reproducibility of Results</topic><topic>Rodents</topic><topic>Sensitivity and Specificity</topic><topic>Severity of Illness Index</topic><topic>Spinal cord injuries</topic><topic>Spinal Cord Injuries - diagnostic imaging</topic><topic>Spinal Cord Injuries - pathology</topic><topic>Spinal Cord Injuries - physiopathology</topic><topic>Studies</topic><topic>Subtraction Technique</topic><topic>White Matter - diagnostic imaging</topic><topic>White Matter - pathology</topic><topic>White Matter - physiopathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zhao, Can</creatorcontrib><creatorcontrib>Rao, Jia-Sheng</creatorcontrib><creatorcontrib>Pei, Xiao-Jiao</creatorcontrib><creatorcontrib>Lei, Jian-Feng</creatorcontrib><creatorcontrib>Wang, Zhan-Jing</creatorcontrib><creatorcontrib>Yang, Zhao-Yang</creatorcontrib><creatorcontrib>Li, Xiao-Guang</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Biotechnology Research Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Neurosciences Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection (ProQuest)</collection><collection>Natural Science Collection (ProQuest)</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Biological Science Database</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>Advanced Technologies & Aerospace Database</collection><collection>ProQuest Advanced Technologies & Aerospace Collection</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>Neuroradiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhao, Can</au><au>Rao, Jia-Sheng</au><au>Pei, Xiao-Jiao</au><au>Lei, Jian-Feng</au><au>Wang, Zhan-Jing</au><au>Yang, Zhao-Yang</au><au>Li, Xiao-Guang</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Longitudinal study on diffusion tensor imaging and diffusion tensor tractography following spinal cord contusion injury in rats</atitle><jtitle>Neuroradiology</jtitle><stitle>Neuroradiology</stitle><addtitle>Neuroradiology</addtitle><date>2016-06-01</date><risdate>2016</risdate><volume>58</volume><issue>6</issue><spage>607</spage><epage>614</epage><pages>607-614</pages><issn>0028-3940</issn><eissn>1432-1920</eissn><abstract>Introduction
Diffusion tensor imaging (DTI) as a potential technology has been used in spinal cord injury (SCI) studies, but the longitudinal evaluation of DTI parameters after SCI, and the correlation between DTI parameters and locomotor outcomes need to be defined.
Methods
Adult Wistar rats (
n
= 6) underwent traumatic thoracic cord contusion by an NYU impactor. DTI and Basso–Beattie–Bresnahan datasets were collected pre-SCI and 1, 3, 7, 14, and 84 days post-SCI. Diffusion tensor tractography (DTT) of the spinal cord was also generated. Fractional anisotropy (FA) and connection rate of fibers at the injury epicenter and at 5 mm rostral/caudal to the epicenter were calculated. The variations of these parameters after SCI were observed by one-way analysis of variance and the correlations between these parameters and motor function were explored by Pearson’s correlation.
Results
FA at the epicenter decreased most remarkably on day 1 post-SCI (from 0.780 ± 0.012 to 0.330 ± 0.015), and continued to decrease slightly by day 3 post-SCI (0.313 ± 0.015), while other parameters decreased significantly over the first 3 days after SCI. DTT showed residual fibers concentrated on ventral and ventrolateral sides of the cord. Moreover, FA at the epicenter exhibited the strongest correlation (
r
= 0.887,
p
= 0.000) with the locomotion performance.
Conclusion
FA was sensitive to degeneration in white matter and DTT could directly reflect the distribution of the residual white matter. Moreover, days 1 to 3 post-SCI may be the optimal time window for SCI examination and therapy.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>26931783</pmid><doi>10.1007/s00234-016-1660-7</doi><tpages>8</tpages></addata></record> |
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| ispartof | Neuroradiology, 2016-06, Vol.58 (6), p.607-614 |
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| subjects | Aging - pathology Animals Anisotropy Diffusion Tensor Imaging - methods Disease Progression Female Functional Neuroradiology Image Interpretation, Computer-Assisted - methods Imaging Longitudinal Studies Medical imaging Medicine Medicine & Public Health Neurology Neuroradiology Neurosciences Neurosurgery Radiology Rats Rats, Wistar Reproducibility of Results Rodents Sensitivity and Specificity Severity of Illness Index Spinal cord injuries Spinal Cord Injuries - diagnostic imaging Spinal Cord Injuries - pathology Spinal Cord Injuries - physiopathology Studies Subtraction Technique White Matter - diagnostic imaging White Matter - pathology White Matter - physiopathology |
| title | Longitudinal study on diffusion tensor imaging and diffusion tensor tractography following spinal cord contusion injury in rats |
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