Functional Analysis of CP2-Like Domain and SAM-Like Domain in TFCP2L1, Novel Pluripotency Factor of Embryonic Stem Cells

TFCP2L1 is a transcription factor that facilitates establishment and maintenance of pluripotency in embryonic stem cells by forming a complex transcriptional network with other transcription factors (OCT4, SOX2, and NANOG). TFCP2L1 contains two distinct domains, the CP2-like domain at the N-terminus...

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Veröffentlicht in:	Applied biochemistry and biotechnology 2016-06, Vol.179 (4), p.650-658
Hauptverfasser:	Kim, Chang Min, Jang, Tae-ho, Park, Hyun Ho
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biochemistry Biotechnology Cell Differentiation - genetics Chemistry Chemistry and Materials Science DNA-Binding Proteins - chemistry DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism Embryonic Stem Cells - chemistry Embryonic Stem Cells - metabolism Embryos Mice Nanog Homeobox Protein - genetics Nanog Homeobox Protein - metabolism Octamer Transcription Factor-3 - genetics Octamer Transcription Factor-3 - metabolism Protein Domains - genetics Protein Multimerization Proteins Repressor Proteins - chemistry Repressor Proteins - genetics Repressor Proteins - metabolism SOXB1 Transcription Factors - genetics SOXB1 Transcription Factors - metabolism Stem cells Transcription factors
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