Exercise improves quality of life in patients with cancer: a systematic review and meta-analysis of randomised controlled trials
PurposeExercise may be associated with increased health-related quality of life (QoL) in patients with cancer, but it is not prescribed as standard care during or after cancer treatment. We systematically reviewed the methodological quality of, and summarised the evidence from, randomised controlled...
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| Veröffentlicht in: | British journal of sports medicine 2016-07, Vol.50 (13), p.796-803 |
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| creator | Gerritsen, Jasper K W Vincent, Arnaud J P E |
| description | PurposeExercise may be associated with increased health-related quality of life (QoL) in patients with cancer, but it is not prescribed as standard care during or after cancer treatment. We systematically reviewed the methodological quality of, and summarised the evidence from, randomised controlled trials (RCTs). A meta-analysis was performed to examine the effectiveness of exercise in improving the QoL in patients with cancer, during and after medical treatment.MethodsRCTs that met the PICO (Patient Intervention Control Outcome) format were included in this study. 16 RCTs were identified through a search of Embase, Medline (OvidSP) and the Cochrane Library. These trials were reviewed for substantive results and the methodological quality was assessed using the Delphi criteria list.ResultsExercise interventions differed widely in content, frequency, duration and intensity. Based on the meta-analysis, exercise improved QoL significantly in patients with cancer as compared to usual care (mean difference 5.55, 95% CI (3.19 to 7.90), p |
| doi_str_mv | 10.1136/bjsports-2015-094787 |
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We systematically reviewed the methodological quality of, and summarised the evidence from, randomised controlled trials (RCTs). A meta-analysis was performed to examine the effectiveness of exercise in improving the QoL in patients with cancer, during and after medical treatment.MethodsRCTs that met the PICO (Patient Intervention Control Outcome) format were included in this study. 16 RCTs were identified through a search of Embase, Medline (OvidSP) and the Cochrane Library. These trials were reviewed for substantive results and the methodological quality was assessed using the Delphi criteria list.ResultsExercise interventions differed widely in content, frequency, duration and intensity. Based on the meta-analysis, exercise improved QoL significantly in patients with cancer as compared to usual care (mean difference 5.55, 95% CI (3.19 to 7.90), p<0.001). Other outcomes closely related to QoL, such as fatigue and physical functioning, also improved.ConclusionsExercise has a direct positive impact on QoL in patients with cancer, during and following medical intervention. Exercise is a clinically relevant treatment and should be an adjunct to disease therapy in oncology.</description><identifier>ISSN: 0306-3674</identifier><identifier>EISSN: 1473-0480</identifier><identifier>DOI: 10.1136/bjsports-2015-094787</identifier><identifier>PMID: 26719503</identifier><language>eng</language><publisher>England: BMJ Publishing Group LTD</publisher><subject>Cancer ; Clinical trials ; Exercise ; Exercise Therapy ; Humans ; Neoplasms - therapy ; Patients ; Quality of Life ; Randomized Controlled Trials as Topic</subject><ispartof>British journal of sports medicine, 2016-07, Vol.50 (13), p.796-803</ispartof><rights>Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing</rights><rights>Copyright: 2016 Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b408t-81373c1341c1a0da3e053630b8111837993132445be6be0e19b7291e417ed9173</citedby><cites>FETCH-LOGICAL-b408t-81373c1341c1a0da3e053630b8111837993132445be6be0e19b7291e417ed9173</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttp://bjsm.bmj.com/content/50/13/796.full.pdf$$EPDF$$P50$$Gbmj$$H</linktopdf><linktohtml>$$Uhttp://bjsm.bmj.com/content/50/13/796.full$$EHTML$$P50$$Gbmj$$H</linktohtml><link.rule.ids>114,115,313,314,776,780,788,3183,23550,27899,27901,27902,77343,77374</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26719503$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gerritsen, Jasper K W</creatorcontrib><creatorcontrib>Vincent, Arnaud J P E</creatorcontrib><title>Exercise improves quality of life in patients with cancer: a systematic review and meta-analysis of randomised controlled trials</title><title>British journal of sports medicine</title><addtitle>Br J Sports Med</addtitle><description>PurposeExercise may be associated with increased health-related quality of life (QoL) in patients with cancer, but it is not prescribed as standard care during or after cancer treatment. We systematically reviewed the methodological quality of, and summarised the evidence from, randomised controlled trials (RCTs). A meta-analysis was performed to examine the effectiveness of exercise in improving the QoL in patients with cancer, during and after medical treatment.MethodsRCTs that met the PICO (Patient Intervention Control Outcome) format were included in this study. 16 RCTs were identified through a search of Embase, Medline (OvidSP) and the Cochrane Library. These trials were reviewed for substantive results and the methodological quality was assessed using the Delphi criteria list.ResultsExercise interventions differed widely in content, frequency, duration and intensity. Based on the meta-analysis, exercise improved QoL significantly in patients with cancer as compared to usual care (mean difference 5.55, 95% CI (3.19 to 7.90), p<0.001). Other outcomes closely related to QoL, such as fatigue and physical functioning, also improved.ConclusionsExercise has a direct positive impact on QoL in patients with cancer, during and following medical intervention. Exercise is a clinically relevant treatment and should be an adjunct to disease therapy in oncology.</description><subject>Cancer</subject><subject>Clinical trials</subject><subject>Exercise</subject><subject>Exercise Therapy</subject><subject>Humans</subject><subject>Neoplasms - therapy</subject><subject>Patients</subject><subject>Quality of Life</subject><subject>Randomized Controlled Trials as Topic</subject><issn>0306-3674</issn><issn>1473-0480</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqNkU1v1DAQhi0EokvhHyBkiQuX0JmMEzvcUFU-pEpc4Bw5zqzwKom3ttOyN346XrblwAVOM5p55h2PXyFeIrxFpPZi2KV9iDlVNWBTQae00Y_EBpWmCpSBx2IDBG1FrVZn4llKOwCsGzBPxVndauwaoI34efWDo_OJpZ_3MdxykjernXw-yLCVk9-WxiL3NntecpJ3Pn-Xzi6O4ztpZTqkzHNpOhn51vOdtMsoZ862soudDsmno0ws1TCXJaN0YckxTFNJc_R2Ss_Fk20J_OI-notvH66-Xn6qrr98_Hz5_roaFJhcGSRNDkmhQwujJYaGWoLBIKIh3XWEVCvVDNwODIzdoOsOWaHmsUNN5-LNSbdcebNyyn15kONpsguHNfVowGhqjKn_jequ_LWqGyro67_QXVhjOf23ICpUrTGFUifKxZBS5G2_j3628dAj9Ecz-wcz-6OZ_cnMMvbqXnwdZh7_DD24V4CLEzDMu_-T_AWsRKwj</recordid><startdate>201607</startdate><enddate>201607</enddate><creator>Gerritsen, Jasper K W</creator><creator>Vincent, Arnaud J P E</creator><general>BMJ Publishing Group LTD</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7TS</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88I</scope><scope>8AF</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>BTHHO</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>M2P</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>201607</creationdate><title>Exercise improves quality of life in patients with cancer: a systematic review and meta-analysis of randomised controlled trials</title><author>Gerritsen, Jasper K W ; Vincent, Arnaud J P E</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b408t-81373c1341c1a0da3e053630b8111837993132445be6be0e19b7291e417ed9173</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Cancer</topic><topic>Clinical trials</topic><topic>Exercise</topic><topic>Exercise Therapy</topic><topic>Humans</topic><topic>Neoplasms - therapy</topic><topic>Patients</topic><topic>Quality of Life</topic><topic>Randomized Controlled Trials as Topic</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gerritsen, Jasper K W</creatorcontrib><creatorcontrib>Vincent, Arnaud J P E</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Physical Education Index</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>STEM Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>BMJ Journals</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Science Database</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>British journal of sports medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gerritsen, Jasper K W</au><au>Vincent, Arnaud J P E</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Exercise improves quality of life in patients with cancer: a systematic review and meta-analysis of randomised controlled trials</atitle><jtitle>British journal of sports medicine</jtitle><addtitle>Br J Sports Med</addtitle><date>2016-07</date><risdate>2016</risdate><volume>50</volume><issue>13</issue><spage>796</spage><epage>803</epage><pages>796-803</pages><issn>0306-3674</issn><eissn>1473-0480</eissn><abstract>PurposeExercise may be associated with increased health-related quality of life (QoL) in patients with cancer, but it is not prescribed as standard care during or after cancer treatment. We systematically reviewed the methodological quality of, and summarised the evidence from, randomised controlled trials (RCTs). A meta-analysis was performed to examine the effectiveness of exercise in improving the QoL in patients with cancer, during and after medical treatment.MethodsRCTs that met the PICO (Patient Intervention Control Outcome) format were included in this study. 16 RCTs were identified through a search of Embase, Medline (OvidSP) and the Cochrane Library. These trials were reviewed for substantive results and the methodological quality was assessed using the Delphi criteria list.ResultsExercise interventions differed widely in content, frequency, duration and intensity. Based on the meta-analysis, exercise improved QoL significantly in patients with cancer as compared to usual care (mean difference 5.55, 95% CI (3.19 to 7.90), p<0.001). Other outcomes closely related to QoL, such as fatigue and physical functioning, also improved.ConclusionsExercise has a direct positive impact on QoL in patients with cancer, during and following medical intervention. Exercise is a clinically relevant treatment and should be an adjunct to disease therapy in oncology.</abstract><cop>England</cop><pub>BMJ Publishing Group LTD</pub><pmid>26719503</pmid><doi>10.1136/bjsports-2015-094787</doi><tpages>8</tpages></addata></record> |
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| subjects | Cancer Clinical trials Exercise Exercise Therapy Humans Neoplasms - therapy Patients Quality of Life Randomized Controlled Trials as Topic |
| title | Exercise improves quality of life in patients with cancer: a systematic review and meta-analysis of randomised controlled trials |
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