Ribosome Inactivation Leads to Attenuation of Intestinal Polymeric Ig Receptor Expression via Differential Regulation of Human Antigen R

The polymeric IgR (pIgR) is a central component in the transport of IgA across enterocytes and thereby plays a crucial role in the defense against enteropathogens and in the regulation of circulating IgA levels. The present study was performed to address the novel regulation of pIgR expression in in...

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Veröffentlicht in:	The Journal of immunology (1950) 2016-08, Vol.197 (3), p.847-858
Hauptverfasser:	Do, Kee Hun, Park, Seong-Hwan, Kim, Juil, Yu, Mira, Moon, Yuseok
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Blotting, Western Cell Line Disease Models, Animal ELAV-Like Protein 1 - metabolism Enterocytes - metabolism Enteropathogenic Escherichia coli Escherichia coli Infections - metabolism Female Flow Cytometry Gene Expression Regulation Humans Immunity, Mucosal - physiology Immunoglobulin A - immunology Immunoglobulin A - metabolism Immunohistochemistry Immunoprecipitation Intestinal Mucosa - metabolism Mice Microscopy, Confocal Polymerase Chain Reaction Receptors, Polymeric Immunoglobulin - biosynthesis Ribosomes - metabolism
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