A humanized bone marrow ossicle xenotransplantation model enables improved engraftment of healthy and leukemic human hematopoietic cells

Mice bearing ossicles containing human bone marrow stromal cells enable improved leukemia engraftment and detection of high frequencies of human leukemia-initiating cells. Xenotransplantation models represent powerful tools for the investigation of healthy and malignant human hematopoiesis. However,...

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Veröffentlicht in:	Nature medicine 2016-07, Vol.22 (7), p.812-821
Hauptverfasser:	Reinisch, Andreas, Thomas, Daniel, Corces, M Ryan, Zhang, Xiaohua, Gratzinger, Dita, Hong, Wan-Jen, Schallmoser, Katharina, Strunk, Dirk, Majeti, Ravindra
Format:	Artikel
Sprache:	eng
Schlagworte:	13/100 13/106 13/31 631/532/1542 631/532/2074 631/532/2139 631/532/71 631/67/327 64/60 82/1 Animals Biomedicine Bone and Bones Bone marrow Bone Marrow Cells Bone Marrow Transplantation Bone Transplantation Cancer Research Cell Differentiation Cellular biology Disease Models, Animal Fetal Blood Hematology Hematopoiesis Hematopoietic Stem Cells Humans Infectious Diseases Leukemia Leukemia, Myeloid, Acute Leukemia, Promyelocytic, Acute Mesenchymal Stem Cells Metabolic Diseases Mice Mice, SCID Molecular Medicine Neoplasm Transplantation Neurosciences Observations Primary Myelofibrosis technical-report Transplantation Transplantation, Heterologous Tumor Microenvironment Xenotransplantation
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