Human metabolites and transformation products of cyclophosphamide and ifosfamide: analysis, occurrence and formation during abiotic treatments

This study describes a gas chromatography-mass spectrometry analytical method for the analysis of cytostatic cyclophosphamide (CP), ifosfamide (IF) and their selected metabolites/transformation products (TPs): carboxy-cyclophosphamide (carboxy-CP), keto-cyclophosphamide (keto-CP) and 3-dechloroethyl...

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Veröffentlicht in:	Environmental science and pollution research international 2016-06, Vol.23 (11), p.11209-11223
Hauptverfasser:	Česen, Marjeta, Kosjek, Tina, Busetti, Francesco, Kompare, Boris, Heath, Ester
Format:	Artikel
Sprache:	eng
Schlagworte:	Analytical methods Antineoplastic Agents, Alkylating - analysis Antineoplastic Agents, Alkylating - metabolism Aquatic Pollution Atmospheric Protection/Air Quality Control/Air Pollution Cell division Chemotherapy Chromatography Cyclophosphamide - analysis Cyclophosphamide - metabolism Cytotoxicity Earth and Environmental Science Ecotoxicology Effluents Environment Environmental Chemistry Environmental Health Environmental Monitoring - methods Environmental science Gas chromatography Gas Chromatography-Mass Spectrometry - methods Hospitals Humans Hydrogen peroxide Ifosfamide - analysis Ifosfamide - metabolism Liquid chromatography Mass spectrometry Metabolites Research Article Scientific imaging Studies Waste Water - analysis Waste Water Technology Water Management Water Pollutants, Chemical - analysis Water Pollutants, Chemical - metabolism Water Pollution Control Water treatment
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