Impact of varicocele on biological markers of gonadal function
Purpose The aim of this study is to evaluate the potential effect of varicocele in the hormonal and clinical profile of adolescents. Methods Twenty adolescents at Tanner stage 4–5 with left varicocele were studied and compared with a control group of 20 healthy adolescents. All patients underwent ul...
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| Veröffentlicht in: | Hernia : the journal of hernias and abdominal wall surgery 2016-06, Vol.20 (3), p.435-439 |
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| container_title | Hernia : the journal of hernias and abdominal wall surgery |
| container_volume | 20 |
| creator | Blevrakis, E. Chatzidarellis, E. Anyfantakis, D. Sakellaris, G. Raissaki, M. Zoras, O. Mamoulakis, C. Sofras, F. Chrysos, E. |
| description | Purpose
The aim of this study is to evaluate the potential effect of varicocele in the hormonal and clinical profile of adolescents.
Methods
Twenty adolescents at Tanner stage 4–5 with left varicocele were studied and compared with a control group of 20 healthy adolescents. All patients underwent ultrasonographic testicular volumetry as well as hormonal evaluation of inhibin B, testosterone, baseline and gonadotropin-releasing hormone stimulated, follicle-stimulating hormone as well as luteinizing hormone. Statistical analysis was performed using the student’s
t
test with
p
value |
| doi_str_mv | 10.1007/s10029-015-1361-x |
| format | Article |
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The aim of this study is to evaluate the potential effect of varicocele in the hormonal and clinical profile of adolescents.
Methods
Twenty adolescents at Tanner stage 4–5 with left varicocele were studied and compared with a control group of 20 healthy adolescents. All patients underwent ultrasonographic testicular volumetry as well as hormonal evaluation of inhibin B, testosterone, baseline and gonadotropin-releasing hormone stimulated, follicle-stimulating hormone as well as luteinizing hormone. Statistical analysis was performed using the student’s
t
test with
p
value <0.05 taken as statistical significant.
Results
Patients with varicocele showed reduced levels of inhibin B compared to controls and a significant reduction in the testicular volume on the affected side. The response of luteinizing hormone to gonadotropin-releasing hormone stimulation was significantly higher in the varicocele group compared to the control group. Furthermore a significant inverse relationship of inhibin B compared to follicle-stimulating hormone was noted.
Conclusion
Serum inhibin B levels could represent a useful marker of Sertoli cell damage caused by varicocele.</description><identifier>ISSN: 1265-4906</identifier><identifier>EISSN: 1248-9204</identifier><identifier>DOI: 10.1007/s10029-015-1361-x</identifier><identifier>PMID: 25731948</identifier><language>eng</language><publisher>Paris: Springer Paris</publisher><subject>Abdominal Surgery ; Adolescent ; Biomarkers - blood ; Follicle Stimulating Hormone - blood ; Gonadotropin-Releasing Hormone - blood ; Gonadotropins, Pituitary - blood ; Humans ; Inhibins - blood ; Luteinizing Hormone - blood ; Male ; Medicine ; Medicine & Public Health ; Original Article ; Testosterone - blood ; Varicocele - blood ; Varicocele - physiopathology</subject><ispartof>Hernia : the journal of hernias and abdominal wall surgery, 2016-06, Vol.20 (3), p.435-439</ispartof><rights>Springer-Verlag France 2015</rights><rights>Springer-Verlag France 2016</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c405t-9b80d359c2074c3d5678f955df74c96a560b11b6b562520f6290a9d6746d71f23</citedby><cites>FETCH-LOGICAL-c405t-9b80d359c2074c3d5678f955df74c96a560b11b6b562520f6290a9d6746d71f23</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10029-015-1361-x$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10029-015-1361-x$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27903,27904,41467,42536,51297</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25731948$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Blevrakis, E.</creatorcontrib><creatorcontrib>Chatzidarellis, E.</creatorcontrib><creatorcontrib>Anyfantakis, D.</creatorcontrib><creatorcontrib>Sakellaris, G.</creatorcontrib><creatorcontrib>Raissaki, M.</creatorcontrib><creatorcontrib>Zoras, O.</creatorcontrib><creatorcontrib>Mamoulakis, C.</creatorcontrib><creatorcontrib>Sofras, F.</creatorcontrib><creatorcontrib>Chrysos, E.</creatorcontrib><title>Impact of varicocele on biological markers of gonadal function</title><title>Hernia : the journal of hernias and abdominal wall surgery</title><addtitle>Hernia</addtitle><addtitle>Hernia</addtitle><description>Purpose
The aim of this study is to evaluate the potential effect of varicocele in the hormonal and clinical profile of adolescents.
Methods
Twenty adolescents at Tanner stage 4–5 with left varicocele were studied and compared with a control group of 20 healthy adolescents. All patients underwent ultrasonographic testicular volumetry as well as hormonal evaluation of inhibin B, testosterone, baseline and gonadotropin-releasing hormone stimulated, follicle-stimulating hormone as well as luteinizing hormone. Statistical analysis was performed using the student’s
t
test with
p
value <0.05 taken as statistical significant.
Results
Patients with varicocele showed reduced levels of inhibin B compared to controls and a significant reduction in the testicular volume on the affected side. The response of luteinizing hormone to gonadotropin-releasing hormone stimulation was significantly higher in the varicocele group compared to the control group. Furthermore a significant inverse relationship of inhibin B compared to follicle-stimulating hormone was noted.
Conclusion
Serum inhibin B levels could represent a useful marker of Sertoli cell damage caused by varicocele.</description><subject>Abdominal Surgery</subject><subject>Adolescent</subject><subject>Biomarkers - blood</subject><subject>Follicle Stimulating Hormone - blood</subject><subject>Gonadotropin-Releasing Hormone - blood</subject><subject>Gonadotropins, Pituitary - blood</subject><subject>Humans</subject><subject>Inhibins - blood</subject><subject>Luteinizing Hormone - blood</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Original Article</subject><subject>Testosterone - blood</subject><subject>Varicocele - blood</subject><subject>Varicocele - physiopathology</subject><issn>1265-4906</issn><issn>1248-9204</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNqFkU1LxDAQhoMo7rr6A7xIwYuX6iTNR3MRZPFjYcGLnkOapkvXtlmTraz_3qxdRQTxkmQyz7zJzIvQKYZLDCCuQlyJTAGzFGccp5s9NMaE5qkkQPe3Z85SKoGP0FEISwDIKc8P0YgwkWFJ8zG6nrUrbdaJq5I37WvjjG1s4rqkqF3jFrXRTdJq_2J92DIL1-kyXlV9Z9a1647RQaWbYE92-wQ9390-TR_S-eP9bHozTw0Ftk5lkUOZMWkICGqyknGRV5Kxsoqh5JpxKDAueME4YQQqTiRoWXJBeSlwRbIJuhh0V9699jasVVuH-NVGd9b1QeEccpERJuX_qJBYUIqxiOj5L3Tpet_FRj4pkgFhLFJ4oIx3IXhbqZWv40zeFQa19UENPqjog9r6oDax5myn3BetLb8rvgYfATIAIaa6hfU_nv5T9QNZnZA8</recordid><startdate>20160601</startdate><enddate>20160601</enddate><creator>Blevrakis, E.</creator><creator>Chatzidarellis, E.</creator><creator>Anyfantakis, D.</creator><creator>Sakellaris, G.</creator><creator>Raissaki, M.</creator><creator>Zoras, O.</creator><creator>Mamoulakis, C.</creator><creator>Sofras, F.</creator><creator>Chrysos, E.</creator><general>Springer Paris</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7T5</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20160601</creationdate><title>Impact of varicocele on biological markers of gonadal function</title><author>Blevrakis, E. ; Chatzidarellis, E. ; Anyfantakis, D. ; Sakellaris, G. ; Raissaki, M. ; Zoras, O. ; Mamoulakis, C. ; Sofras, F. ; Chrysos, E.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c405t-9b80d359c2074c3d5678f955df74c96a560b11b6b562520f6290a9d6746d71f23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Abdominal Surgery</topic><topic>Adolescent</topic><topic>Biomarkers - blood</topic><topic>Follicle Stimulating Hormone - blood</topic><topic>Gonadotropin-Releasing Hormone - blood</topic><topic>Gonadotropins, Pituitary - blood</topic><topic>Humans</topic><topic>Inhibins - blood</topic><topic>Luteinizing Hormone - blood</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Original Article</topic><topic>Testosterone - blood</topic><topic>Varicocele - blood</topic><topic>Varicocele - physiopathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Blevrakis, E.</creatorcontrib><creatorcontrib>Chatzidarellis, E.</creatorcontrib><creatorcontrib>Anyfantakis, D.</creatorcontrib><creatorcontrib>Sakellaris, G.</creatorcontrib><creatorcontrib>Raissaki, M.</creatorcontrib><creatorcontrib>Zoras, O.</creatorcontrib><creatorcontrib>Mamoulakis, C.</creatorcontrib><creatorcontrib>Sofras, F.</creatorcontrib><creatorcontrib>Chrysos, E.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Immunology Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Hernia : the journal of hernias and abdominal wall surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Blevrakis, E.</au><au>Chatzidarellis, E.</au><au>Anyfantakis, D.</au><au>Sakellaris, G.</au><au>Raissaki, M.</au><au>Zoras, O.</au><au>Mamoulakis, C.</au><au>Sofras, F.</au><au>Chrysos, E.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Impact of varicocele on biological markers of gonadal function</atitle><jtitle>Hernia : the journal of hernias and abdominal wall surgery</jtitle><stitle>Hernia</stitle><addtitle>Hernia</addtitle><date>2016-06-01</date><risdate>2016</risdate><volume>20</volume><issue>3</issue><spage>435</spage><epage>439</epage><pages>435-439</pages><issn>1265-4906</issn><eissn>1248-9204</eissn><abstract>Purpose
The aim of this study is to evaluate the potential effect of varicocele in the hormonal and clinical profile of adolescents.
Methods
Twenty adolescents at Tanner stage 4–5 with left varicocele were studied and compared with a control group of 20 healthy adolescents. All patients underwent ultrasonographic testicular volumetry as well as hormonal evaluation of inhibin B, testosterone, baseline and gonadotropin-releasing hormone stimulated, follicle-stimulating hormone as well as luteinizing hormone. Statistical analysis was performed using the student’s
t
test with
p
value <0.05 taken as statistical significant.
Results
Patients with varicocele showed reduced levels of inhibin B compared to controls and a significant reduction in the testicular volume on the affected side. The response of luteinizing hormone to gonadotropin-releasing hormone stimulation was significantly higher in the varicocele group compared to the control group. Furthermore a significant inverse relationship of inhibin B compared to follicle-stimulating hormone was noted.
Conclusion
Serum inhibin B levels could represent a useful marker of Sertoli cell damage caused by varicocele.</abstract><cop>Paris</cop><pub>Springer Paris</pub><pmid>25731948</pmid><doi>10.1007/s10029-015-1361-x</doi><tpages>5</tpages></addata></record> |
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| identifier | ISSN: 1265-4906 |
| ispartof | Hernia : the journal of hernias and abdominal wall surgery, 2016-06, Vol.20 (3), p.435-439 |
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| source | MEDLINE; SpringerLink Journals - AutoHoldings |
| subjects | Abdominal Surgery Adolescent Biomarkers - blood Follicle Stimulating Hormone - blood Gonadotropin-Releasing Hormone - blood Gonadotropins, Pituitary - blood Humans Inhibins - blood Luteinizing Hormone - blood Male Medicine Medicine & Public Health Original Article Testosterone - blood Varicocele - blood Varicocele - physiopathology |
| title | Impact of varicocele on biological markers of gonadal function |
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