Multistate Outbreak of Respiratory Infections Among Unaccompanied Children, June 2014–July 2014
Background. From January 2014–July 2014, more than 46 000 unaccompanied children (UC) from Central America crossed the US–Mexico border. In June–July, UC aged 9–17 years in 4 shelters and 1 processing center in 4 states were hospitalized with acute respiratory illness. We conducted a multistate inve...
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| Veröffentlicht in: | Clinical infectious diseases 2016-07, Vol.63 (1), p.48-56 |
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| creator | Tomczyk, Sara Arriola, Carmen S. Beall, Bernard Benitez, Alvaro Benoit, Stephen R. Berman, LaShondra Bresee, Joseph Carvalho, Maria da Gloria Cohn, Amanda Cross, Kristen Diaz, Maureen H. Watkins, Louise K. Francois Gierke, Ryan Hagan, Jose E. Harris, Aaron M. Jain, Seema Kim, Lindsay Kobayashi, Miwako Lindstrom, Stephen McGee, Lesley McMorrow, Meredith Metcalf, Benjamin L. Moore, Matthew R. Moura, Iaci Nix, W. Allan Nyangoma, Edith Oberste, M. Steven Olsen, Sonja J. Pimenta, Fabiana Socias, Christina Thurman, Kathleen Waller, Jessica Waterman, Stephen H. Westercamp, Matthew Wharton, Melinda Whitney, Cynthia G. Winchell, Jonas M. Wolff, Bernard Kim, Curi |
| description | Background. From January 2014–July 2014, more than 46 000 unaccompanied children (UC) from Central America crossed the US–Mexico border. In June–July, UC aged 9–17 years in 4 shelters and 1 processing center in 4 states were hospitalized with acute respiratory illness. We conducted a multistate investigation to interrupt disease transmission. Methods. Medical charts were abstracted for hospitalized UC. Nonhospitalized UC with influenza-like illness were interviewed, and nasopharyngeal and oropharyngeal swabs were collected to detect respiratory pathogens. Nasopharyngeal swabs were used to assess pneumococcal colonization in symptomatic and asymptomatic UC. Pneumococcal blood isolates from hospitalized UC and nasopharyngeal isolates were characterized by serotyping and whole-genome sequencing. Results. Among 15 hospitalized UC, 4 (44%) of 9 tested positive for influenza viruses, and 6 (43%) of 14 with blood cultures grew pneumococcus, all serotype 5. Among 48 nonhospitalized children with influenza-like illness, 1 or more respiratory pathogens were identified in 46 (96%). Among 774 nonhospitalized UC, 185 (24%) yielded pneumococcus, and 70 (38%) were serotype 5. UC transferring through the processing center were more likely to be colonized with serotype 5 (odds ratio, 3.8; 95% confidence interval, 2.1–6.9). Analysis of core pneumococcal genomes detected 2 related, yet independent, clusters. No pneumococcus cases were reported after pneumococcal and influenza immunization campaigns. Conclusions. This respiratory disease outbreak was due to multiple pathogens, including Streptococcus pneumoniae serotype 5 and influenza viruses. Pneumococcal and influenza vaccinations prevented further transmission. Future efforts to prevent similar outbreaks will benefit from use of both vaccines. |
| doi_str_mv | 10.1093/cid/ciw147 |
| format | Article |
| fullrecord | <record><control><sourceid>jstor_proqu</sourceid><recordid>TN_cdi_proquest_miscellaneous_1808730394</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><jstor_id>26371578</jstor_id><sourcerecordid>26371578</sourcerecordid><originalsourceid>FETCH-LOGICAL-c406t-e8b532b6f60b80e968ccad1be1a840b036f4aed144ac9cc1014dddddc4ebe4833</originalsourceid><addsrcrecordid>eNqFkctKxDAUhoMoXkY37pWAGxGrySRtkqUMXlEGRNclTU-1Y5uMSYvMznfwDX0SM44XcGMg5Id8fHDOj9A2JUeUKHZs6jLeF8rFElqnKRNJliq6HDNJZcIlk2toI4QJIZRKkq6itaGIWSi1jvRN33R16HQHeNx3hQf9hF2FbyFMa68752f40lZgutrZgE9aZx_wvdXGuHaqbQ0lHj3WTenBHuKr3gIeEsrfX9-u-mb2mTfRSqWbAFtf7wDdn53ejS6S6_H55ejkOjGcZF0CskjZsMiqjBSSgMqkMbqkBVAtOSkIyyquoaSca6OModFczo_hUECckQ3Q_sI79e65h9DlbR0MNI224PqQx9GlYIQp_j8qVCplROfWvT_oxPXexkHmQiKiTslIHSwo410IHqp86utW-1lOST7vKI8d5YuOIrz7peyLFsof9LuUCOwsgEmI-__9z5igqZDsA7U-luQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1800739498</pqid></control><display><type>article</type><title>Multistate Outbreak of Respiratory Infections Among Unaccompanied Children, June 2014–July 2014</title><source>Jstor Complete Legacy</source><source>Oxford University Press Journals All Titles (1996-Current)</source><source>MEDLINE</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>Alma/SFX Local Collection</source><creator>Tomczyk, Sara ; Arriola, Carmen S. ; Beall, Bernard ; Benitez, Alvaro ; Benoit, Stephen R. ; Berman, LaShondra ; Bresee, Joseph ; Carvalho, Maria da Gloria ; Cohn, Amanda ; Cross, Kristen ; Diaz, Maureen H. ; Watkins, Louise K. Francois ; Gierke, Ryan ; Hagan, Jose E. ; Harris, Aaron M. ; Jain, Seema ; Kim, Lindsay ; Kobayashi, Miwako ; Lindstrom, Stephen ; McGee, Lesley ; McMorrow, Meredith ; Metcalf, Benjamin L. ; Moore, Matthew R. ; Moura, Iaci ; Nix, W. Allan ; Nyangoma, Edith ; Oberste, M. Steven ; Olsen, Sonja J. ; Pimenta, Fabiana ; Socias, Christina ; Thurman, Kathleen ; Waller, Jessica ; Waterman, Stephen H. ; Westercamp, Matthew ; Wharton, Melinda ; Whitney, Cynthia G. ; Winchell, Jonas M. ; Wolff, Bernard ; Kim, Curi</creator><creatorcontrib>Tomczyk, Sara ; Arriola, Carmen S. ; Beall, Bernard ; Benitez, Alvaro ; Benoit, Stephen R. ; Berman, LaShondra ; Bresee, Joseph ; Carvalho, Maria da Gloria ; Cohn, Amanda ; Cross, Kristen ; Diaz, Maureen H. ; Watkins, Louise K. Francois ; Gierke, Ryan ; Hagan, Jose E. ; Harris, Aaron M. ; Jain, Seema ; Kim, Lindsay ; Kobayashi, Miwako ; Lindstrom, Stephen ; McGee, Lesley ; McMorrow, Meredith ; Metcalf, Benjamin L. ; Moore, Matthew R. ; Moura, Iaci ; Nix, W. Allan ; Nyangoma, Edith ; Oberste, M. Steven ; Olsen, Sonja J. ; Pimenta, Fabiana ; Socias, Christina ; Thurman, Kathleen ; Waller, Jessica ; Waterman, Stephen H. ; Westercamp, Matthew ; Wharton, Melinda ; Whitney, Cynthia G. ; Winchell, Jonas M. ; Wolff, Bernard ; Kim, Curi</creatorcontrib><description>Background. From January 2014–July 2014, more than 46 000 unaccompanied children (UC) from Central America crossed the US–Mexico border. In June–July, UC aged 9–17 years in 4 shelters and 1 processing center in 4 states were hospitalized with acute respiratory illness. We conducted a multistate investigation to interrupt disease transmission. Methods. Medical charts were abstracted for hospitalized UC. Nonhospitalized UC with influenza-like illness were interviewed, and nasopharyngeal and oropharyngeal swabs were collected to detect respiratory pathogens. Nasopharyngeal swabs were used to assess pneumococcal colonization in symptomatic and asymptomatic UC. Pneumococcal blood isolates from hospitalized UC and nasopharyngeal isolates were characterized by serotyping and whole-genome sequencing. Results. Among 15 hospitalized UC, 4 (44%) of 9 tested positive for influenza viruses, and 6 (43%) of 14 with blood cultures grew pneumococcus, all serotype 5. Among 48 nonhospitalized children with influenza-like illness, 1 or more respiratory pathogens were identified in 46 (96%). Among 774 nonhospitalized UC, 185 (24%) yielded pneumococcus, and 70 (38%) were serotype 5. UC transferring through the processing center were more likely to be colonized with serotype 5 (odds ratio, 3.8; 95% confidence interval, 2.1–6.9). Analysis of core pneumococcal genomes detected 2 related, yet independent, clusters. No pneumococcus cases were reported after pneumococcal and influenza immunization campaigns. Conclusions. This respiratory disease outbreak was due to multiple pathogens, including Streptococcus pneumoniae serotype 5 and influenza viruses. Pneumococcal and influenza vaccinations prevented further transmission. Future efforts to prevent similar outbreaks will benefit from use of both vaccines.</description><identifier>ISSN: 1058-4838</identifier><identifier>EISSN: 1537-6591</identifier><identifier>DOI: 10.1093/cid/ciw147</identifier><identifier>PMID: 27001799</identifier><language>eng</language><publisher>United States: Oxford University Press</publisher><subject><![CDATA[Adolescent ; ARTICLES AND COMMENTARIES ; Bacteria ; Child ; Children & youth ; Disease Outbreaks - statistics & numerical data ; Disease transmission ; Female ; Genomes ; Hospitalization ; Humans ; Immunization ; Influenza ; Influenza Vaccines ; Influenza, Human - epidemiology ; Influenza, Human - prevention & control ; Influenza, Human - virology ; Male ; Mexico - ethnology ; Nasopharynx - microbiology ; Nasopharynx - virology ; Orthomyxoviridae ; Pneumococcal Vaccines ; Pneumonia, Pneumococcal - epidemiology ; Pneumonia, Pneumococcal - microbiology ; Pneumonia, Pneumococcal - prevention & control ; Refugees - statistics & numerical data ; Respiratory Tract Infections - epidemiology ; Respiratory Tract Infections - microbiology ; Respiratory Tract Infections - prevention & control ; Risk Factors ; Streptococcus pneumoniae ; United States - epidemiology ; Vaccines ; Vulnerable Populations - statistics & numerical data]]></subject><ispartof>Clinical infectious diseases, 2016-07, Vol.63 (1), p.48-56</ispartof><rights>Copyright © 2016 Oxford University Press on behalf of the Infectious Diseases Society of America</rights><rights>Published by Oxford University Press for the Infectious Diseases Society of America 2016. This work is written by (a) US Government employee(s) and is in the public domain in the US.</rights><rights>Copyright Oxford University Press, UK Jul 1, 2016</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c406t-e8b532b6f60b80e968ccad1be1a840b036f4aed144ac9cc1014dddddc4ebe4833</citedby><cites>FETCH-LOGICAL-c406t-e8b532b6f60b80e968ccad1be1a840b036f4aed144ac9cc1014dddddc4ebe4833</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/26371578$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/26371578$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>314,776,780,799,27901,27902,57992,58225</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27001799$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tomczyk, Sara</creatorcontrib><creatorcontrib>Arriola, Carmen S.</creatorcontrib><creatorcontrib>Beall, Bernard</creatorcontrib><creatorcontrib>Benitez, Alvaro</creatorcontrib><creatorcontrib>Benoit, Stephen R.</creatorcontrib><creatorcontrib>Berman, LaShondra</creatorcontrib><creatorcontrib>Bresee, Joseph</creatorcontrib><creatorcontrib>Carvalho, Maria da Gloria</creatorcontrib><creatorcontrib>Cohn, Amanda</creatorcontrib><creatorcontrib>Cross, Kristen</creatorcontrib><creatorcontrib>Diaz, Maureen H.</creatorcontrib><creatorcontrib>Watkins, Louise K. Francois</creatorcontrib><creatorcontrib>Gierke, Ryan</creatorcontrib><creatorcontrib>Hagan, Jose E.</creatorcontrib><creatorcontrib>Harris, Aaron M.</creatorcontrib><creatorcontrib>Jain, Seema</creatorcontrib><creatorcontrib>Kim, Lindsay</creatorcontrib><creatorcontrib>Kobayashi, Miwako</creatorcontrib><creatorcontrib>Lindstrom, Stephen</creatorcontrib><creatorcontrib>McGee, Lesley</creatorcontrib><creatorcontrib>McMorrow, Meredith</creatorcontrib><creatorcontrib>Metcalf, Benjamin L.</creatorcontrib><creatorcontrib>Moore, Matthew R.</creatorcontrib><creatorcontrib>Moura, Iaci</creatorcontrib><creatorcontrib>Nix, W. Allan</creatorcontrib><creatorcontrib>Nyangoma, Edith</creatorcontrib><creatorcontrib>Oberste, M. Steven</creatorcontrib><creatorcontrib>Olsen, Sonja J.</creatorcontrib><creatorcontrib>Pimenta, Fabiana</creatorcontrib><creatorcontrib>Socias, Christina</creatorcontrib><creatorcontrib>Thurman, Kathleen</creatorcontrib><creatorcontrib>Waller, Jessica</creatorcontrib><creatorcontrib>Waterman, Stephen H.</creatorcontrib><creatorcontrib>Westercamp, Matthew</creatorcontrib><creatorcontrib>Wharton, Melinda</creatorcontrib><creatorcontrib>Whitney, Cynthia G.</creatorcontrib><creatorcontrib>Winchell, Jonas M.</creatorcontrib><creatorcontrib>Wolff, Bernard</creatorcontrib><creatorcontrib>Kim, Curi</creatorcontrib><title>Multistate Outbreak of Respiratory Infections Among Unaccompanied Children, June 2014–July 2014</title><title>Clinical infectious diseases</title><addtitle>Clin Infect Dis</addtitle><description>Background. From January 2014–July 2014, more than 46 000 unaccompanied children (UC) from Central America crossed the US–Mexico border. In June–July, UC aged 9–17 years in 4 shelters and 1 processing center in 4 states were hospitalized with acute respiratory illness. We conducted a multistate investigation to interrupt disease transmission. Methods. Medical charts were abstracted for hospitalized UC. Nonhospitalized UC with influenza-like illness were interviewed, and nasopharyngeal and oropharyngeal swabs were collected to detect respiratory pathogens. Nasopharyngeal swabs were used to assess pneumococcal colonization in symptomatic and asymptomatic UC. Pneumococcal blood isolates from hospitalized UC and nasopharyngeal isolates were characterized by serotyping and whole-genome sequencing. Results. Among 15 hospitalized UC, 4 (44%) of 9 tested positive for influenza viruses, and 6 (43%) of 14 with blood cultures grew pneumococcus, all serotype 5. Among 48 nonhospitalized children with influenza-like illness, 1 or more respiratory pathogens were identified in 46 (96%). Among 774 nonhospitalized UC, 185 (24%) yielded pneumococcus, and 70 (38%) were serotype 5. UC transferring through the processing center were more likely to be colonized with serotype 5 (odds ratio, 3.8; 95% confidence interval, 2.1–6.9). Analysis of core pneumococcal genomes detected 2 related, yet independent, clusters. No pneumococcus cases were reported after pneumococcal and influenza immunization campaigns. Conclusions. This respiratory disease outbreak was due to multiple pathogens, including Streptococcus pneumoniae serotype 5 and influenza viruses. Pneumococcal and influenza vaccinations prevented further transmission. Future efforts to prevent similar outbreaks will benefit from use of both vaccines.</description><subject>Adolescent</subject><subject>ARTICLES AND COMMENTARIES</subject><subject>Bacteria</subject><subject>Child</subject><subject>Children & youth</subject><subject>Disease Outbreaks - statistics & numerical data</subject><subject>Disease transmission</subject><subject>Female</subject><subject>Genomes</subject><subject>Hospitalization</subject><subject>Humans</subject><subject>Immunization</subject><subject>Influenza</subject><subject>Influenza Vaccines</subject><subject>Influenza, Human - epidemiology</subject><subject>Influenza, Human - prevention & control</subject><subject>Influenza, Human - virology</subject><subject>Male</subject><subject>Mexico - ethnology</subject><subject>Nasopharynx - microbiology</subject><subject>Nasopharynx - virology</subject><subject>Orthomyxoviridae</subject><subject>Pneumococcal Vaccines</subject><subject>Pneumonia, Pneumococcal - epidemiology</subject><subject>Pneumonia, Pneumococcal - microbiology</subject><subject>Pneumonia, Pneumococcal - prevention & control</subject><subject>Refugees - statistics & numerical data</subject><subject>Respiratory Tract Infections - epidemiology</subject><subject>Respiratory Tract Infections - microbiology</subject><subject>Respiratory Tract Infections - prevention & control</subject><subject>Risk Factors</subject><subject>Streptococcus pneumoniae</subject><subject>United States - epidemiology</subject><subject>Vaccines</subject><subject>Vulnerable Populations - statistics & numerical data</subject><issn>1058-4838</issn><issn>1537-6591</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkctKxDAUhoMoXkY37pWAGxGrySRtkqUMXlEGRNclTU-1Y5uMSYvMznfwDX0SM44XcGMg5Id8fHDOj9A2JUeUKHZs6jLeF8rFElqnKRNJliq6HDNJZcIlk2toI4QJIZRKkq6itaGIWSi1jvRN33R16HQHeNx3hQf9hF2FbyFMa68752f40lZgutrZgE9aZx_wvdXGuHaqbQ0lHj3WTenBHuKr3gIeEsrfX9-u-mb2mTfRSqWbAFtf7wDdn53ejS6S6_H55ejkOjGcZF0CskjZsMiqjBSSgMqkMbqkBVAtOSkIyyquoaSca6OModFczo_hUECckQ3Q_sI79e65h9DlbR0MNI224PqQx9GlYIQp_j8qVCplROfWvT_oxPXexkHmQiKiTslIHSwo410IHqp86utW-1lOST7vKI8d5YuOIrz7peyLFsof9LuUCOwsgEmI-__9z5igqZDsA7U-luQ</recordid><startdate>20160701</startdate><enddate>20160701</enddate><creator>Tomczyk, Sara</creator><creator>Arriola, Carmen S.</creator><creator>Beall, Bernard</creator><creator>Benitez, Alvaro</creator><creator>Benoit, Stephen R.</creator><creator>Berman, LaShondra</creator><creator>Bresee, Joseph</creator><creator>Carvalho, Maria da Gloria</creator><creator>Cohn, Amanda</creator><creator>Cross, Kristen</creator><creator>Diaz, Maureen H.</creator><creator>Watkins, Louise K. Francois</creator><creator>Gierke, Ryan</creator><creator>Hagan, Jose E.</creator><creator>Harris, Aaron M.</creator><creator>Jain, Seema</creator><creator>Kim, Lindsay</creator><creator>Kobayashi, Miwako</creator><creator>Lindstrom, Stephen</creator><creator>McGee, Lesley</creator><creator>McMorrow, Meredith</creator><creator>Metcalf, Benjamin L.</creator><creator>Moore, Matthew R.</creator><creator>Moura, Iaci</creator><creator>Nix, W. Allan</creator><creator>Nyangoma, Edith</creator><creator>Oberste, M. Steven</creator><creator>Olsen, Sonja J.</creator><creator>Pimenta, Fabiana</creator><creator>Socias, Christina</creator><creator>Thurman, Kathleen</creator><creator>Waller, Jessica</creator><creator>Waterman, Stephen H.</creator><creator>Westercamp, Matthew</creator><creator>Wharton, Melinda</creator><creator>Whitney, Cynthia G.</creator><creator>Winchell, Jonas M.</creator><creator>Wolff, Bernard</creator><creator>Kim, Curi</creator><general>Oxford University Press</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7T2</scope><scope>7T7</scope><scope>7U7</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>K9.</scope><scope>M7N</scope><scope>P64</scope><scope>7X8</scope><scope>7U2</scope></search><sort><creationdate>20160701</creationdate><title>Multistate Outbreak of Respiratory Infections Among Unaccompanied Children, June 2014–July 2014</title><author>Tomczyk, Sara ; Arriola, Carmen S. ; Beall, Bernard ; Benitez, Alvaro ; Benoit, Stephen R. ; Berman, LaShondra ; Bresee, Joseph ; Carvalho, Maria da Gloria ; Cohn, Amanda ; Cross, Kristen ; Diaz, Maureen H. ; Watkins, Louise K. Francois ; Gierke, Ryan ; Hagan, Jose E. ; Harris, Aaron M. ; Jain, Seema ; Kim, Lindsay ; Kobayashi, Miwako ; Lindstrom, Stephen ; McGee, Lesley ; McMorrow, Meredith ; Metcalf, Benjamin L. ; Moore, Matthew R. ; Moura, Iaci ; Nix, W. Allan ; Nyangoma, Edith ; Oberste, M. Steven ; Olsen, Sonja J. ; Pimenta, Fabiana ; Socias, Christina ; Thurman, Kathleen ; Waller, Jessica ; Waterman, Stephen H. ; Westercamp, Matthew ; Wharton, Melinda ; Whitney, Cynthia G. ; Winchell, Jonas M. ; Wolff, Bernard ; Kim, Curi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c406t-e8b532b6f60b80e968ccad1be1a840b036f4aed144ac9cc1014dddddc4ebe4833</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Adolescent</topic><topic>ARTICLES AND COMMENTARIES</topic><topic>Bacteria</topic><topic>Child</topic><topic>Children & youth</topic><topic>Disease Outbreaks - statistics & numerical data</topic><topic>Disease transmission</topic><topic>Female</topic><topic>Genomes</topic><topic>Hospitalization</topic><topic>Humans</topic><topic>Immunization</topic><topic>Influenza</topic><topic>Influenza Vaccines</topic><topic>Influenza, Human - epidemiology</topic><topic>Influenza, Human - prevention & control</topic><topic>Influenza, Human - virology</topic><topic>Male</topic><topic>Mexico - ethnology</topic><topic>Nasopharynx - microbiology</topic><topic>Nasopharynx - virology</topic><topic>Orthomyxoviridae</topic><topic>Pneumococcal Vaccines</topic><topic>Pneumonia, Pneumococcal - epidemiology</topic><topic>Pneumonia, Pneumococcal - microbiology</topic><topic>Pneumonia, Pneumococcal - prevention & control</topic><topic>Refugees - statistics & numerical data</topic><topic>Respiratory Tract Infections - epidemiology</topic><topic>Respiratory Tract Infections - microbiology</topic><topic>Respiratory Tract Infections - prevention & control</topic><topic>Risk Factors</topic><topic>Streptococcus pneumoniae</topic><topic>United States - epidemiology</topic><topic>Vaccines</topic><topic>Vulnerable Populations - statistics & numerical data</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tomczyk, Sara</creatorcontrib><creatorcontrib>Arriola, Carmen S.</creatorcontrib><creatorcontrib>Beall, Bernard</creatorcontrib><creatorcontrib>Benitez, Alvaro</creatorcontrib><creatorcontrib>Benoit, Stephen R.</creatorcontrib><creatorcontrib>Berman, LaShondra</creatorcontrib><creatorcontrib>Bresee, Joseph</creatorcontrib><creatorcontrib>Carvalho, Maria da Gloria</creatorcontrib><creatorcontrib>Cohn, Amanda</creatorcontrib><creatorcontrib>Cross, Kristen</creatorcontrib><creatorcontrib>Diaz, Maureen H.</creatorcontrib><creatorcontrib>Watkins, Louise K. Francois</creatorcontrib><creatorcontrib>Gierke, Ryan</creatorcontrib><creatorcontrib>Hagan, Jose E.</creatorcontrib><creatorcontrib>Harris, Aaron M.</creatorcontrib><creatorcontrib>Jain, Seema</creatorcontrib><creatorcontrib>Kim, Lindsay</creatorcontrib><creatorcontrib>Kobayashi, Miwako</creatorcontrib><creatorcontrib>Lindstrom, Stephen</creatorcontrib><creatorcontrib>McGee, Lesley</creatorcontrib><creatorcontrib>McMorrow, Meredith</creatorcontrib><creatorcontrib>Metcalf, Benjamin L.</creatorcontrib><creatorcontrib>Moore, Matthew R.</creatorcontrib><creatorcontrib>Moura, Iaci</creatorcontrib><creatorcontrib>Nix, W. Allan</creatorcontrib><creatorcontrib>Nyangoma, Edith</creatorcontrib><creatorcontrib>Oberste, M. Steven</creatorcontrib><creatorcontrib>Olsen, Sonja J.</creatorcontrib><creatorcontrib>Pimenta, Fabiana</creatorcontrib><creatorcontrib>Socias, Christina</creatorcontrib><creatorcontrib>Thurman, Kathleen</creatorcontrib><creatorcontrib>Waller, Jessica</creatorcontrib><creatorcontrib>Waterman, Stephen H.</creatorcontrib><creatorcontrib>Westercamp, Matthew</creatorcontrib><creatorcontrib>Wharton, Melinda</creatorcontrib><creatorcontrib>Whitney, Cynthia G.</creatorcontrib><creatorcontrib>Winchell, Jonas M.</creatorcontrib><creatorcontrib>Wolff, Bernard</creatorcontrib><creatorcontrib>Kim, Curi</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Health and Safety Science Abstracts (Full archive)</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Toxicology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><collection>Safety Science and Risk</collection><jtitle>Clinical infectious diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tomczyk, Sara</au><au>Arriola, Carmen S.</au><au>Beall, Bernard</au><au>Benitez, Alvaro</au><au>Benoit, Stephen R.</au><au>Berman, LaShondra</au><au>Bresee, Joseph</au><au>Carvalho, Maria da Gloria</au><au>Cohn, Amanda</au><au>Cross, Kristen</au><au>Diaz, Maureen H.</au><au>Watkins, Louise K. Francois</au><au>Gierke, Ryan</au><au>Hagan, Jose E.</au><au>Harris, Aaron M.</au><au>Jain, Seema</au><au>Kim, Lindsay</au><au>Kobayashi, Miwako</au><au>Lindstrom, Stephen</au><au>McGee, Lesley</au><au>McMorrow, Meredith</au><au>Metcalf, Benjamin L.</au><au>Moore, Matthew R.</au><au>Moura, Iaci</au><au>Nix, W. Allan</au><au>Nyangoma, Edith</au><au>Oberste, M. Steven</au><au>Olsen, Sonja J.</au><au>Pimenta, Fabiana</au><au>Socias, Christina</au><au>Thurman, Kathleen</au><au>Waller, Jessica</au><au>Waterman, Stephen H.</au><au>Westercamp, Matthew</au><au>Wharton, Melinda</au><au>Whitney, Cynthia G.</au><au>Winchell, Jonas M.</au><au>Wolff, Bernard</au><au>Kim, Curi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Multistate Outbreak of Respiratory Infections Among Unaccompanied Children, June 2014–July 2014</atitle><jtitle>Clinical infectious diseases</jtitle><addtitle>Clin Infect Dis</addtitle><date>2016-07-01</date><risdate>2016</risdate><volume>63</volume><issue>1</issue><spage>48</spage><epage>56</epage><pages>48-56</pages><issn>1058-4838</issn><eissn>1537-6591</eissn><abstract>Background. From January 2014–July 2014, more than 46 000 unaccompanied children (UC) from Central America crossed the US–Mexico border. In June–July, UC aged 9–17 years in 4 shelters and 1 processing center in 4 states were hospitalized with acute respiratory illness. We conducted a multistate investigation to interrupt disease transmission. Methods. Medical charts were abstracted for hospitalized UC. Nonhospitalized UC with influenza-like illness were interviewed, and nasopharyngeal and oropharyngeal swabs were collected to detect respiratory pathogens. Nasopharyngeal swabs were used to assess pneumococcal colonization in symptomatic and asymptomatic UC. Pneumococcal blood isolates from hospitalized UC and nasopharyngeal isolates were characterized by serotyping and whole-genome sequencing. Results. Among 15 hospitalized UC, 4 (44%) of 9 tested positive for influenza viruses, and 6 (43%) of 14 with blood cultures grew pneumococcus, all serotype 5. Among 48 nonhospitalized children with influenza-like illness, 1 or more respiratory pathogens were identified in 46 (96%). Among 774 nonhospitalized UC, 185 (24%) yielded pneumococcus, and 70 (38%) were serotype 5. UC transferring through the processing center were more likely to be colonized with serotype 5 (odds ratio, 3.8; 95% confidence interval, 2.1–6.9). Analysis of core pneumococcal genomes detected 2 related, yet independent, clusters. No pneumococcus cases were reported after pneumococcal and influenza immunization campaigns. Conclusions. This respiratory disease outbreak was due to multiple pathogens, including Streptococcus pneumoniae serotype 5 and influenza viruses. Pneumococcal and influenza vaccinations prevented further transmission. Future efforts to prevent similar outbreaks will benefit from use of both vaccines.</abstract><cop>United States</cop><pub>Oxford University Press</pub><pmid>27001799</pmid><doi>10.1093/cid/ciw147</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1058-4838 |
| ispartof | Clinical infectious diseases, 2016-07, Vol.63 (1), p.48-56 |
| issn | 1058-4838 1537-6591 |
| language | eng |
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| source | Jstor Complete Legacy; Oxford University Press Journals All Titles (1996-Current); MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | Adolescent ARTICLES AND COMMENTARIES Bacteria Child Children & youth Disease Outbreaks - statistics & numerical data Disease transmission Female Genomes Hospitalization Humans Immunization Influenza Influenza Vaccines Influenza, Human - epidemiology Influenza, Human - prevention & control Influenza, Human - virology Male Mexico - ethnology Nasopharynx - microbiology Nasopharynx - virology Orthomyxoviridae Pneumococcal Vaccines Pneumonia, Pneumococcal - epidemiology Pneumonia, Pneumococcal - microbiology Pneumonia, Pneumococcal - prevention & control Refugees - statistics & numerical data Respiratory Tract Infections - epidemiology Respiratory Tract Infections - microbiology Respiratory Tract Infections - prevention & control Risk Factors Streptococcus pneumoniae United States - epidemiology Vaccines Vulnerable Populations - statistics & numerical data |
| title | Multistate Outbreak of Respiratory Infections Among Unaccompanied Children, June 2014–July 2014 |
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