RP-HPLC METHOD DEVELOPMENT AND VALIDATION OF STABILITY INDICATING METHOD A FOR ESTIMATION OF LOSARTAN POTASSIUM UNDER STRESS CONDITION AND TABLET DOSAGE FORM

RP-HPLC METHOD DEVELOPMENT AND VALIDATION OF STABILITY INDICATING METHOD A FOR ESTIMATION OF LOSARTAN POTASSIUM UNDER STRESS CONDITION AND TABLET DOSAGE FORM

Losartan potassium, a highly effective blood pressure lowering agent, has widely used for treatment of hypertension. Simple, economic, selective, and precise and stability indicating HPLC method has been developed and validated for analysis of losartan potassium in bulk drug and formulation dosage f...

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Veröffentlicht in:International journal of pharmaceutical sciences and research 2016-06, Vol.7 (6), p.2343-2343
Hauptverfasser: Mohammed, Amna B W E, Rudwan, Elsadig H
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Rudwan, Elsadig H
description Losartan potassium, a highly effective blood pressure lowering agent, has widely used for treatment of hypertension. Simple, economic, selective, and precise and stability indicating HPLC method has been developed and validated for analysis of losartan potassium in bulk drug and formulation dosage form. In order to optimize more one response at time, the chemo metric approach which includes 2 super( 3) factorial design at two level with three factors was set up to standardize the chromatographic condition. The mobile phase was 40:60 ACN: Buffer consist of 0.05% of orthophosphoric acid and 0.05% Triethylamine at flow rate 1.0ml/minute the eluent was monitored at 225nm. The calibration plots constructed using the concentration of 6.4 to 9.6 mu g/ml (80-120%) with r super( 2) =0.999, recovery =99.44% was indicative of accuracy of proposed method. The precision was calculated as repeatability, intraday for the drug.
doi_str_mv 10.13040/IJPSR.0975-8232.7(6).2343-51
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title RP-HPLC METHOD DEVELOPMENT AND VALIDATION OF STABILITY INDICATING METHOD A FOR ESTIMATION OF LOSARTAN POTASSIUM UNDER STRESS CONDITION AND TABLET DOSAGE FORM
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