Probiotic lactobacilli inhibit early stages of Candida albicans biofilm development by reducing their growth, cell adhesion, and filamentation
We evaluated the inhibitory effects of the probiotic Lactobacillus species on different phases of Candida albicans biofilm development. Quantification of biofilm growth and ultrastructural analyses were performed on C. albicans biofilms treated with Lactobacillus rhamnosus , Lactobacillus casei , an...
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| Veröffentlicht in: | Applied microbiology and biotechnology 2016-07, Vol.100 (14), p.6415-6426 |
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| container_title | Applied microbiology and biotechnology |
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| creator | Matsubara, Victor Haruo Wang, Yi Bandara, H. M. H. N. Mayer, Marcia Pinto Alves Samaranayake, Lakshman P. |
| description | We evaluated the inhibitory effects of the probiotic
Lactobacillus
species on different phases of
Candida albicans
biofilm development. Quantification of biofilm growth and ultrastructural analyses were performed on
C. albicans
biofilms treated with
Lactobacillus rhamnosus
,
Lactobacillus casei
, and
Lactobacillus acidophilus
planktonic cell suspensions as well as their supernatants. Planktonic lactobacilli induced a significant reduction (
p
0.05), but significantly reduced the early stages of
Candida
biofilm formation (
p
|
| doi_str_mv | 10.1007/s00253-016-7527-3 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_proqu</sourceid><recordid>TN_cdi_proquest_miscellaneous_1808729885</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A470592028</galeid><sourcerecordid>A470592028</sourcerecordid><originalsourceid>FETCH-LOGICAL-c586t-c16b50b01b608f63e49c0233172173e3e1f00ff047e1314a00e1eee0a37b04243</originalsourceid><addsrcrecordid>eNqFkl2L1DAUhoso7rj6A7yRgDcK2_UkaZv2chn8WFhQ_LgOaXrayZJJxiRV50_4m02d9WNEkVwEcp73Je_hLYqHFM4pgHgWAVjNS6BNKWomSn6rWNGKsxIaWt0uVkBFnSdde1Lci_EagLK2ae4WJ0xAmxX1qvj6Jvje-GQ0sUon3yttrDXEuI3pTSKogt2TmNSEkfiRrJUbzKCIsr3RykWSxaOxWzLgJ7R-t0WXSL8nAYdZGzeRtEETyBT857Q5IxqtJWrYYDTenZFsRrJaLSqV8tP94s6obMQHN_dp8eHF8_frV-XV65eX64urUtdtk0pNm76GHmjfQDs2HKtOA-OcCkYFR450BBhHqARSTisFgBQRQXHRQ8Uqflo8Ofjugv84Y0xya-LyOeXQz1HSNi-IdW1b_x8VXdt1FWt4Rh__gV77Obgc5DuVkaptflGTsiiNG30KSi-m8qISUHcMWJup879Q-Qy4Ndo7zHvDY8HTI0FmEn5Jk5pjlJfv3h6z9MDq4GMMOMpdMFsV9pKCXKolD9WSuVpyqZZcwj26CTf3Wxx-Kn50KQPsAMQ8chOG39L_0_UbiUTW7g</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1798263486</pqid></control><display><type>article</type><title>Probiotic lactobacilli inhibit early stages of Candida albicans biofilm development by reducing their growth, cell adhesion, and filamentation</title><source>MEDLINE</source><source>SpringerLink</source><creator>Matsubara, Victor Haruo ; Wang, Yi ; Bandara, H. M. H. N. ; Mayer, Marcia Pinto Alves ; Samaranayake, Lakshman P.</creator><creatorcontrib>Matsubara, Victor Haruo ; Wang, Yi ; Bandara, H. M. H. N. ; Mayer, Marcia Pinto Alves ; Samaranayake, Lakshman P.</creatorcontrib><description>We evaluated the inhibitory effects of the probiotic
Lactobacillus
species on different phases of
Candida albicans
biofilm development. Quantification of biofilm growth and ultrastructural analyses were performed on
C. albicans
biofilms treated with
Lactobacillus rhamnosus
,
Lactobacillus casei
, and
Lactobacillus acidophilus
planktonic cell suspensions as well as their supernatants. Planktonic lactobacilli induced a significant reduction (
p
< 0.05) in the number of biofilm cells (25.5–61.8 %) depending on the probiotic strain and the biofilm phase.
L. rhamnosus
supernatants had no significant effect on the mature biofilm (
p
> 0.05), but significantly reduced the early stages of
Candida
biofilm formation (
p
< 0.01). Microscopic analyses revealed that
L. rhamnosus
suspensions reduced
Candida
hyphal differentiation, leading to a predominance of budding growth. All lactobacilli negatively impacted
C. albicans
yeast-to-hyphae differentiation and biofilm formation. The inhibitory effects of the probiotic
Lactobacillus
on
C. albicans
entailed both cell-cell interactions and secretion of exometabolites that may impact on pathogenic attributes associated with
C. albicans
colonization on host surfaces and yeast filamentation. This study clarifies, for the first time, the mechanics of how
Lactobacillus
species may antagonize
C. albicans
host colonization. Our data elucidate the inhibitory mechanisms that define the probiotic candicidal activity of lactobacilli, thus supporting their utility as an adjunctive therapeutic mode against mucosal candidal infections.</description><identifier>ISSN: 0175-7598</identifier><identifier>EISSN: 1432-0614</identifier><identifier>DOI: 10.1007/s00253-016-7527-3</identifier><identifier>PMID: 27087525</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Analysis ; Antibiosis ; Antifungal agents ; Applied Microbial and Cell Physiology ; Bacteria ; Biofilms ; Biomedical and Life Sciences ; Biotechnology ; Candida albicans ; Candida albicans - growth & development ; Candidiasis ; Care and treatment ; Cell Adhesion ; Cell adhesion & migration ; Colonization ; Culture Media ; Dentistry ; Drug resistance ; Fungi ; Health aspects ; Hyphae - growth & development ; Infections ; Lactobacillus ; Lactobacillus acidophilus ; Lactobacillus acidophilus - physiology ; Lactobacillus casei ; Lactobacillus rhamnosus ; Lactobacillus rhamnosus - physiology ; Life Sciences ; Microbial Genetics and Genomics ; Microbial mats ; Microbiology ; Microscopy ; Physiological aspects ; Probiotics ; Studies ; Yeasts</subject><ispartof>Applied microbiology and biotechnology, 2016-07, Vol.100 (14), p.6415-6426</ispartof><rights>Springer-Verlag Berlin Heidelberg 2016</rights><rights>COPYRIGHT 2016 Springer</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c586t-c16b50b01b608f63e49c0233172173e3e1f00ff047e1314a00e1eee0a37b04243</citedby><cites>FETCH-LOGICAL-c586t-c16b50b01b608f63e49c0233172173e3e1f00ff047e1314a00e1eee0a37b04243</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00253-016-7527-3$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00253-016-7527-3$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27087525$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Matsubara, Victor Haruo</creatorcontrib><creatorcontrib>Wang, Yi</creatorcontrib><creatorcontrib>Bandara, H. M. H. N.</creatorcontrib><creatorcontrib>Mayer, Marcia Pinto Alves</creatorcontrib><creatorcontrib>Samaranayake, Lakshman P.</creatorcontrib><title>Probiotic lactobacilli inhibit early stages of Candida albicans biofilm development by reducing their growth, cell adhesion, and filamentation</title><title>Applied microbiology and biotechnology</title><addtitle>Appl Microbiol Biotechnol</addtitle><addtitle>Appl Microbiol Biotechnol</addtitle><description>We evaluated the inhibitory effects of the probiotic
Lactobacillus
species on different phases of
Candida albicans
biofilm development. Quantification of biofilm growth and ultrastructural analyses were performed on
C. albicans
biofilms treated with
Lactobacillus rhamnosus
,
Lactobacillus casei
, and
Lactobacillus acidophilus
planktonic cell suspensions as well as their supernatants. Planktonic lactobacilli induced a significant reduction (
p
< 0.05) in the number of biofilm cells (25.5–61.8 %) depending on the probiotic strain and the biofilm phase.
L. rhamnosus
supernatants had no significant effect on the mature biofilm (
p
> 0.05), but significantly reduced the early stages of
Candida
biofilm formation (
p
< 0.01). Microscopic analyses revealed that
L. rhamnosus
suspensions reduced
Candida
hyphal differentiation, leading to a predominance of budding growth. All lactobacilli negatively impacted
C. albicans
yeast-to-hyphae differentiation and biofilm formation. The inhibitory effects of the probiotic
Lactobacillus
on
C. albicans
entailed both cell-cell interactions and secretion of exometabolites that may impact on pathogenic attributes associated with
C. albicans
colonization on host surfaces and yeast filamentation. This study clarifies, for the first time, the mechanics of how
Lactobacillus
species may antagonize
C. albicans
host colonization. Our data elucidate the inhibitory mechanisms that define the probiotic candicidal activity of lactobacilli, thus supporting their utility as an adjunctive therapeutic mode against mucosal candidal infections.</description><subject>Analysis</subject><subject>Antibiosis</subject><subject>Antifungal agents</subject><subject>Applied Microbial and Cell Physiology</subject><subject>Bacteria</subject><subject>Biofilms</subject><subject>Biomedical and Life Sciences</subject><subject>Biotechnology</subject><subject>Candida albicans</subject><subject>Candida albicans - growth & development</subject><subject>Candidiasis</subject><subject>Care and treatment</subject><subject>Cell Adhesion</subject><subject>Cell adhesion & migration</subject><subject>Colonization</subject><subject>Culture Media</subject><subject>Dentistry</subject><subject>Drug resistance</subject><subject>Fungi</subject><subject>Health aspects</subject><subject>Hyphae - growth & development</subject><subject>Infections</subject><subject>Lactobacillus</subject><subject>Lactobacillus acidophilus</subject><subject>Lactobacillus acidophilus - physiology</subject><subject>Lactobacillus casei</subject><subject>Lactobacillus rhamnosus</subject><subject>Lactobacillus rhamnosus - physiology</subject><subject>Life Sciences</subject><subject>Microbial Genetics and Genomics</subject><subject>Microbial mats</subject><subject>Microbiology</subject><subject>Microscopy</subject><subject>Physiological aspects</subject><subject>Probiotics</subject><subject>Studies</subject><subject>Yeasts</subject><issn>0175-7598</issn><issn>1432-0614</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNqFkl2L1DAUhoso7rj6A7yRgDcK2_UkaZv2chn8WFhQ_LgOaXrayZJJxiRV50_4m02d9WNEkVwEcp73Je_hLYqHFM4pgHgWAVjNS6BNKWomSn6rWNGKsxIaWt0uVkBFnSdde1Lci_EagLK2ae4WJ0xAmxX1qvj6Jvje-GQ0sUon3yttrDXEuI3pTSKogt2TmNSEkfiRrJUbzKCIsr3RykWSxaOxWzLgJ7R-t0WXSL8nAYdZGzeRtEETyBT857Q5IxqtJWrYYDTenZFsRrJaLSqV8tP94s6obMQHN_dp8eHF8_frV-XV65eX64urUtdtk0pNm76GHmjfQDs2HKtOA-OcCkYFR450BBhHqARSTisFgBQRQXHRQ8Uqflo8Ofjugv84Y0xya-LyOeXQz1HSNi-IdW1b_x8VXdt1FWt4Rh__gV77Obgc5DuVkaptflGTsiiNG30KSi-m8qISUHcMWJup879Q-Qy4Ndo7zHvDY8HTI0FmEn5Jk5pjlJfv3h6z9MDq4GMMOMpdMFsV9pKCXKolD9WSuVpyqZZcwj26CTf3Wxx-Kn50KQPsAMQ8chOG39L_0_UbiUTW7g</recordid><startdate>20160701</startdate><enddate>20160701</enddate><creator>Matsubara, Victor Haruo</creator><creator>Wang, Yi</creator><creator>Bandara, H. 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N. ; Mayer, Marcia Pinto Alves ; Samaranayake, Lakshman P.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c586t-c16b50b01b608f63e49c0233172173e3e1f00ff047e1314a00e1eee0a37b04243</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Analysis</topic><topic>Antibiosis</topic><topic>Antifungal agents</topic><topic>Applied Microbial and Cell Physiology</topic><topic>Bacteria</topic><topic>Biofilms</topic><topic>Biomedical and Life Sciences</topic><topic>Biotechnology</topic><topic>Candida albicans</topic><topic>Candida albicans - growth & development</topic><topic>Candidiasis</topic><topic>Care and treatment</topic><topic>Cell Adhesion</topic><topic>Cell adhesion & migration</topic><topic>Colonization</topic><topic>Culture Media</topic><topic>Dentistry</topic><topic>Drug resistance</topic><topic>Fungi</topic><topic>Health aspects</topic><topic>Hyphae - growth & development</topic><topic>Infections</topic><topic>Lactobacillus</topic><topic>Lactobacillus acidophilus</topic><topic>Lactobacillus acidophilus - physiology</topic><topic>Lactobacillus casei</topic><topic>Lactobacillus rhamnosus</topic><topic>Lactobacillus rhamnosus - physiology</topic><topic>Life Sciences</topic><topic>Microbial Genetics and Genomics</topic><topic>Microbial mats</topic><topic>Microbiology</topic><topic>Microscopy</topic><topic>Physiological aspects</topic><topic>Probiotics</topic><topic>Studies</topic><topic>Yeasts</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Matsubara, Victor Haruo</creatorcontrib><creatorcontrib>Wang, Yi</creatorcontrib><creatorcontrib>Bandara, H. 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M. H. N.</au><au>Mayer, Marcia Pinto Alves</au><au>Samaranayake, Lakshman P.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Probiotic lactobacilli inhibit early stages of Candida albicans biofilm development by reducing their growth, cell adhesion, and filamentation</atitle><jtitle>Applied microbiology and biotechnology</jtitle><stitle>Appl Microbiol Biotechnol</stitle><addtitle>Appl Microbiol Biotechnol</addtitle><date>2016-07-01</date><risdate>2016</risdate><volume>100</volume><issue>14</issue><spage>6415</spage><epage>6426</epage><pages>6415-6426</pages><issn>0175-7598</issn><eissn>1432-0614</eissn><abstract>We evaluated the inhibitory effects of the probiotic
Lactobacillus
species on different phases of
Candida albicans
biofilm development. Quantification of biofilm growth and ultrastructural analyses were performed on
C. albicans
biofilms treated with
Lactobacillus rhamnosus
,
Lactobacillus casei
, and
Lactobacillus acidophilus
planktonic cell suspensions as well as their supernatants. Planktonic lactobacilli induced a significant reduction (
p
< 0.05) in the number of biofilm cells (25.5–61.8 %) depending on the probiotic strain and the biofilm phase.
L. rhamnosus
supernatants had no significant effect on the mature biofilm (
p
> 0.05), but significantly reduced the early stages of
Candida
biofilm formation (
p
< 0.01). Microscopic analyses revealed that
L. rhamnosus
suspensions reduced
Candida
hyphal differentiation, leading to a predominance of budding growth. All lactobacilli negatively impacted
C. albicans
yeast-to-hyphae differentiation and biofilm formation. The inhibitory effects of the probiotic
Lactobacillus
on
C. albicans
entailed both cell-cell interactions and secretion of exometabolites that may impact on pathogenic attributes associated with
C. albicans
colonization on host surfaces and yeast filamentation. This study clarifies, for the first time, the mechanics of how
Lactobacillus
species may antagonize
C. albicans
host colonization. Our data elucidate the inhibitory mechanisms that define the probiotic candicidal activity of lactobacilli, thus supporting their utility as an adjunctive therapeutic mode against mucosal candidal infections.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>27087525</pmid><doi>10.1007/s00253-016-7527-3</doi><tpages>12</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0175-7598 |
| ispartof | Applied microbiology and biotechnology, 2016-07, Vol.100 (14), p.6415-6426 |
| issn | 0175-7598 1432-0614 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1808729885 |
| source | MEDLINE; SpringerLink |
| subjects | Analysis Antibiosis Antifungal agents Applied Microbial and Cell Physiology Bacteria Biofilms Biomedical and Life Sciences Biotechnology Candida albicans Candida albicans - growth & development Candidiasis Care and treatment Cell Adhesion Cell adhesion & migration Colonization Culture Media Dentistry Drug resistance Fungi Health aspects Hyphae - growth & development Infections Lactobacillus Lactobacillus acidophilus Lactobacillus acidophilus - physiology Lactobacillus casei Lactobacillus rhamnosus Lactobacillus rhamnosus - physiology Life Sciences Microbial Genetics and Genomics Microbial mats Microbiology Microscopy Physiological aspects Probiotics Studies Yeasts |
| title | Probiotic lactobacilli inhibit early stages of Candida albicans biofilm development by reducing their growth, cell adhesion, and filamentation |
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