Association between age at onset of multiple sclerosis and vitamin D level-related factors
To compare vitamin D level-associated single-nucleotide polymorphisms (SNPs) in GC and CYP2R1, multiple sclerosis (MS) risk SNPs in CYP27B1, CYP24A1, and HLA-DRB1*1501, and adolescent exposure to environmental risk factors for hypovitaminosis D, with MS age at onset. This cross-sectional study inclu...
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| Veröffentlicht in: | Neurology 2016-01, Vol.86 (1), p.88-93 |
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| creator | Laursen, Julie Hejgaard Søndergaard, Helle Bach Sørensen, Per Soelberg Sellebjerg, Finn Oturai, Annette Bang |
| description | To compare vitamin D level-associated single-nucleotide polymorphisms (SNPs) in GC and CYP2R1, multiple sclerosis (MS) risk SNPs in CYP27B1, CYP24A1, and HLA-DRB1*1501, and adolescent exposure to environmental risk factors for hypovitaminosis D, with MS age at onset.
This cross-sectional study included 1161 Danish patients with MS; lifestyle questionnaires and blood samples for genotyping were collected from all participants from 2009 to 2012. Information on age at onset was obtained from the Danish MS Treatment Registry. Written informed consent was obtained from all study participants, and the study was approved by the local ethics committee.
Younger age at onset was significantly associated with low exposure to summer sun in adolescence, higher body mass index at 20 years of age, and the HLA-DRB1*1501 risk allele in both univariate analyses and in a multivariable regression analysis. No association was found between age at onset and any of the other SNPs or vitamin D-associated environmental factors.
We demonstrate an independent effect by HLA-DRB1*1501, adolescent summer sun habits, and body mass index at the age of 20 on age at onset of MS. |
| doi_str_mv | 10.1212/WNL.0000000000002075 |
| format | Article |
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This cross-sectional study included 1161 Danish patients with MS; lifestyle questionnaires and blood samples for genotyping were collected from all participants from 2009 to 2012. Information on age at onset was obtained from the Danish MS Treatment Registry. Written informed consent was obtained from all study participants, and the study was approved by the local ethics committee.
Younger age at onset was significantly associated with low exposure to summer sun in adolescence, higher body mass index at 20 years of age, and the HLA-DRB1*1501 risk allele in both univariate analyses and in a multivariable regression analysis. No association was found between age at onset and any of the other SNPs or vitamin D-associated environmental factors.
We demonstrate an independent effect by HLA-DRB1*1501, adolescent summer sun habits, and body mass index at the age of 20 on age at onset of MS.</description><identifier>ISSN: 0028-3878</identifier><identifier>EISSN: 1526-632X</identifier><identifier>DOI: 10.1212/WNL.0000000000002075</identifier><identifier>PMID: 26446064</identifier><language>eng</language><publisher>United States</publisher><subject>Adult ; Age of Onset ; Cross-Sectional Studies ; Female ; Genetic Association Studies - trends ; HLA-DRB1 Chains - genetics ; Humans ; Life Style ; Male ; Middle Aged ; Multiple Sclerosis - blood ; Multiple Sclerosis - diagnosis ; Multiple Sclerosis - genetics ; Risk Factors ; Sunbathing - trends ; Surveys and Questionnaires ; Vitamin D - blood ; Vitamin D Deficiency - blood ; Vitamin D Deficiency - diagnosis ; Vitamin D Deficiency - genetics ; Young Adult</subject><ispartof>Neurology, 2016-01, Vol.86 (1), p.88-93</ispartof><rights>2015 American Academy of Neurology.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c340t-12b403584399670ad83afd6b1c88286f21be9d8a12b7e425bcf81feffc3a2a853</citedby><cites>FETCH-LOGICAL-c340t-12b403584399670ad83afd6b1c88286f21be9d8a12b7e425bcf81feffc3a2a853</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26446064$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Laursen, Julie Hejgaard</creatorcontrib><creatorcontrib>Søndergaard, Helle Bach</creatorcontrib><creatorcontrib>Sørensen, Per Soelberg</creatorcontrib><creatorcontrib>Sellebjerg, Finn</creatorcontrib><creatorcontrib>Oturai, Annette Bang</creatorcontrib><title>Association between age at onset of multiple sclerosis and vitamin D level-related factors</title><title>Neurology</title><addtitle>Neurology</addtitle><description>To compare vitamin D level-associated single-nucleotide polymorphisms (SNPs) in GC and CYP2R1, multiple sclerosis (MS) risk SNPs in CYP27B1, CYP24A1, and HLA-DRB1*1501, and adolescent exposure to environmental risk factors for hypovitaminosis D, with MS age at onset.
This cross-sectional study included 1161 Danish patients with MS; lifestyle questionnaires and blood samples for genotyping were collected from all participants from 2009 to 2012. Information on age at onset was obtained from the Danish MS Treatment Registry. Written informed consent was obtained from all study participants, and the study was approved by the local ethics committee.
Younger age at onset was significantly associated with low exposure to summer sun in adolescence, higher body mass index at 20 years of age, and the HLA-DRB1*1501 risk allele in both univariate analyses and in a multivariable regression analysis. No association was found between age at onset and any of the other SNPs or vitamin D-associated environmental factors.
We demonstrate an independent effect by HLA-DRB1*1501, adolescent summer sun habits, and body mass index at the age of 20 on age at onset of MS.</description><subject>Adult</subject><subject>Age of Onset</subject><subject>Cross-Sectional Studies</subject><subject>Female</subject><subject>Genetic Association Studies - trends</subject><subject>HLA-DRB1 Chains - genetics</subject><subject>Humans</subject><subject>Life Style</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Multiple Sclerosis - blood</subject><subject>Multiple Sclerosis - diagnosis</subject><subject>Multiple Sclerosis - genetics</subject><subject>Risk Factors</subject><subject>Sunbathing - trends</subject><subject>Surveys and Questionnaires</subject><subject>Vitamin D - blood</subject><subject>Vitamin D Deficiency - blood</subject><subject>Vitamin D Deficiency - diagnosis</subject><subject>Vitamin D Deficiency - genetics</subject><subject>Young Adult</subject><issn>0028-3878</issn><issn>1526-632X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFUU1LAzEQDaLY-vEPRHL0sjXfmz2W-glFL4riZclmJxLJ7tZNWvHfu6VVxItzmIGZ994w8xA6oWRCGWXnT3fzCfkVjORyB42pZCpTnD3vovHQ1BnXuR6hgxjfCBmGebGPRkwJoYgSY_QyjbGz3iTftbiC9AHQYvMK2CTctRGG7HCzDMkvAuBoA_Rd9BGbtsYrn0zjW3yBA6wgZD0Ek6DGztjU9fEI7TkTIhxv6yF6vLp8mN1k8_vr29l0nlkuSMooqwThUgteFConptbcuFpV1GrNtHKMVlDU2gy4HASTlXWaOnDOcsOMlvwQnW10F333voSYysZHCyGYFrplLKkmOmdaS_I_NJdMakWLtarYQO1wcOzBlYveN6b_LCkp1waUgwHlXwMG2ul2w7JqoP4hfX-cfwHWiIDd</recordid><startdate>20160105</startdate><enddate>20160105</enddate><creator>Laursen, Julie Hejgaard</creator><creator>Søndergaard, Helle Bach</creator><creator>Sørensen, Per Soelberg</creator><creator>Sellebjerg, Finn</creator><creator>Oturai, Annette Bang</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7TK</scope></search><sort><creationdate>20160105</creationdate><title>Association between age at onset of multiple sclerosis and vitamin D level-related factors</title><author>Laursen, Julie Hejgaard ; Søndergaard, Helle Bach ; Sørensen, Per Soelberg ; Sellebjerg, Finn ; Oturai, Annette Bang</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c340t-12b403584399670ad83afd6b1c88286f21be9d8a12b7e425bcf81feffc3a2a853</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Adult</topic><topic>Age of Onset</topic><topic>Cross-Sectional Studies</topic><topic>Female</topic><topic>Genetic Association Studies - trends</topic><topic>HLA-DRB1 Chains - genetics</topic><topic>Humans</topic><topic>Life Style</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Multiple Sclerosis - blood</topic><topic>Multiple Sclerosis - diagnosis</topic><topic>Multiple Sclerosis - genetics</topic><topic>Risk Factors</topic><topic>Sunbathing - trends</topic><topic>Surveys and Questionnaires</topic><topic>Vitamin D - blood</topic><topic>Vitamin D Deficiency - blood</topic><topic>Vitamin D Deficiency - diagnosis</topic><topic>Vitamin D Deficiency - genetics</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Laursen, Julie Hejgaard</creatorcontrib><creatorcontrib>Søndergaard, Helle Bach</creatorcontrib><creatorcontrib>Sørensen, Per Soelberg</creatorcontrib><creatorcontrib>Sellebjerg, Finn</creatorcontrib><creatorcontrib>Oturai, Annette Bang</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Neurosciences Abstracts</collection><jtitle>Neurology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Laursen, Julie Hejgaard</au><au>Søndergaard, Helle Bach</au><au>Sørensen, Per Soelberg</au><au>Sellebjerg, Finn</au><au>Oturai, Annette Bang</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Association between age at onset of multiple sclerosis and vitamin D level-related factors</atitle><jtitle>Neurology</jtitle><addtitle>Neurology</addtitle><date>2016-01-05</date><risdate>2016</risdate><volume>86</volume><issue>1</issue><spage>88</spage><epage>93</epage><pages>88-93</pages><issn>0028-3878</issn><eissn>1526-632X</eissn><abstract>To compare vitamin D level-associated single-nucleotide polymorphisms (SNPs) in GC and CYP2R1, multiple sclerosis (MS) risk SNPs in CYP27B1, CYP24A1, and HLA-DRB1*1501, and adolescent exposure to environmental risk factors for hypovitaminosis D, with MS age at onset.
This cross-sectional study included 1161 Danish patients with MS; lifestyle questionnaires and blood samples for genotyping were collected from all participants from 2009 to 2012. Information on age at onset was obtained from the Danish MS Treatment Registry. Written informed consent was obtained from all study participants, and the study was approved by the local ethics committee.
Younger age at onset was significantly associated with low exposure to summer sun in adolescence, higher body mass index at 20 years of age, and the HLA-DRB1*1501 risk allele in both univariate analyses and in a multivariable regression analysis. No association was found between age at onset and any of the other SNPs or vitamin D-associated environmental factors.
We demonstrate an independent effect by HLA-DRB1*1501, adolescent summer sun habits, and body mass index at the age of 20 on age at onset of MS.</abstract><cop>United States</cop><pmid>26446064</pmid><doi>10.1212/WNL.0000000000002075</doi><tpages>6</tpages></addata></record> |
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| ispartof | Neurology, 2016-01, Vol.86 (1), p.88-93 |
| issn | 0028-3878 1526-632X |
| language | eng |
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| source | MEDLINE; Alma/SFX Local Collection; Journals@Ovid Complete |
| subjects | Adult Age of Onset Cross-Sectional Studies Female Genetic Association Studies - trends HLA-DRB1 Chains - genetics Humans Life Style Male Middle Aged Multiple Sclerosis - blood Multiple Sclerosis - diagnosis Multiple Sclerosis - genetics Risk Factors Sunbathing - trends Surveys and Questionnaires Vitamin D - blood Vitamin D Deficiency - blood Vitamin D Deficiency - diagnosis Vitamin D Deficiency - genetics Young Adult |
| title | Association between age at onset of multiple sclerosis and vitamin D level-related factors |
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