One-year clinical study of NeuroRegen scaffold implantation following scar resection in complete chronic spinal cord injury patients
The objective of this clinical study was to assess the safety and feasibility of the collagen scaffold, NeuroRegen scaffold, one year after scar tissue resection and implantation. Scar tissue is a physical and chemical barrier that prevents neural regeneration However, identification of scar tissue...
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| Veröffentlicht in: | Science China. Life sciences 2016-07, Vol.59 (7), p.647-655 |
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| creator | Xiao, Zhifeng Tang, Fengwu Tang, Jiaguang Yang, Huilin Zhao, Yannan Chen, Bing Han, Sufang Wang, Nuo Li, Xing Cheng, Shixiang Han, Guang Zhao, Changyu Yang, Xiaoxiong Chen, Yumei Shi, Qin Hou, Shuxun Zhang, Sai Dai, Jianwu |
| description | The objective of this clinical study was to assess the safety and feasibility of the collagen scaffold, NeuroRegen scaffold, one year after scar tissue resection and implantation. Scar tissue is a physical and chemical barrier that prevents neural regeneration However, identification of scar tissue is still a major challenge. In this study, the nerve electrophysiology method was used to distinguish scar tissue from normal neural tissue, and then different lengths of scars ranging from 0.5-4.5 cm were surgically resected in five complete chronic spinal cord injury （SCI） patients. The NeuroRegen scaffold along with autologous bone marrow mononuclear cells （BMMCs）, which have been proven to promote neural regeneration and SCI recovery in animal models, were transplanted into the gap in the spinal cord following scar tissue resection. No obvious adverse effects related to scar resection or NeuroRegen scaffold transplantation were observed immediately after surgery or at the 12-month follow-up. In addition, patients showed partially autonomic nervous function improvement, and the recovery of somatosensory evoked potentials （SSEP） from the lower limbs was also detected. The results indicate that scar resection and NeuroRegen scaffold transplantation could be a promising clinical approach to treating SCI. |
| doi_str_mv | 10.1007/s11427-016-5080-z |
| format | Article |
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Scar tissue is a physical and chemical barrier that prevents neural regeneration However, identification of scar tissue is still a major challenge. In this study, the nerve electrophysiology method was used to distinguish scar tissue from normal neural tissue, and then different lengths of scars ranging from 0.5-4.5 cm were surgically resected in five complete chronic spinal cord injury （SCI） patients. The NeuroRegen scaffold along with autologous bone marrow mononuclear cells （BMMCs）, which have been proven to promote neural regeneration and SCI recovery in animal models, were transplanted into the gap in the spinal cord following scar tissue resection. No obvious adverse effects related to scar resection or NeuroRegen scaffold transplantation were observed immediately after surgery or at the 12-month follow-up. In addition, patients showed partially autonomic nervous function improvement, and the recovery of somatosensory evoked potentials （SSEP） from the lower limbs was also detected. The results indicate that scar resection and NeuroRegen scaffold transplantation could be a promising clinical approach to treating SCI.</description><identifier>ISSN: 1674-7305</identifier><identifier>EISSN: 1869-1889</identifier><identifier>DOI: 10.1007/s11427-016-5080-z</identifier><identifier>PMID: 27333785</identifier><language>eng</language><publisher>Beijing: Science China Press</publisher><subject>Adult ; Biomedical and Life Sciences ; Cicatrix - surgery ; Cover Article ; Female ; Humans ; Life Sciences ; Male ; Middle Aged ; Nerve Regeneration ; Spinal Cord Injuries - physiopathology ; Spinal Cord Injuries - surgery ; Tissue Scaffolds ; Treatment Outcome ; 临床 ; 患者 ; 慢性 ; 支架 ; 瘢痕 ; 神经组织 ; 脊髓损伤 ; 骨髓单个核细胞</subject><ispartof>Science China. Life sciences, 2016-07, Vol.59 (7), p.647-655</ispartof><rights>The Author(s) 2016</rights><rights>Science in China Press and Springer-Verlag GmbH 2016</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c541t-474a0fb887237f290902bf52a9c7055de7c8e76b095714b8dccfc7222cf76f1e3</citedby><cites>FETCH-LOGICAL-c541t-474a0fb887237f290902bf52a9c7055de7c8e76b095714b8dccfc7222cf76f1e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Uhttp://image.cqvip.com/vip1000/qk/60112X/60112X.jpg</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s11427-016-5080-z$$EPDF$$P50$$Gspringer$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s11427-016-5080-z$$EHTML$$P50$$Gspringer$$Hfree_for_read</linktohtml><link.rule.ids>314,776,780,27903,27904,41467,42536,51297</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27333785$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Xiao, Zhifeng</creatorcontrib><creatorcontrib>Tang, Fengwu</creatorcontrib><creatorcontrib>Tang, Jiaguang</creatorcontrib><creatorcontrib>Yang, Huilin</creatorcontrib><creatorcontrib>Zhao, Yannan</creatorcontrib><creatorcontrib>Chen, Bing</creatorcontrib><creatorcontrib>Han, Sufang</creatorcontrib><creatorcontrib>Wang, Nuo</creatorcontrib><creatorcontrib>Li, Xing</creatorcontrib><creatorcontrib>Cheng, Shixiang</creatorcontrib><creatorcontrib>Han, Guang</creatorcontrib><creatorcontrib>Zhao, Changyu</creatorcontrib><creatorcontrib>Yang, Xiaoxiong</creatorcontrib><creatorcontrib>Chen, Yumei</creatorcontrib><creatorcontrib>Shi, Qin</creatorcontrib><creatorcontrib>Hou, Shuxun</creatorcontrib><creatorcontrib>Zhang, Sai</creatorcontrib><creatorcontrib>Dai, Jianwu</creatorcontrib><title>One-year clinical study of NeuroRegen scaffold implantation following scar resection in complete chronic spinal cord injury patients</title><title>Science China. Life sciences</title><addtitle>Sci. China Life Sci</addtitle><addtitle>Sci China Life Sci</addtitle><description>The objective of this clinical study was to assess the safety and feasibility of the collagen scaffold, NeuroRegen scaffold, one year after scar tissue resection and implantation. Scar tissue is a physical and chemical barrier that prevents neural regeneration However, identification of scar tissue is still a major challenge. In this study, the nerve electrophysiology method was used to distinguish scar tissue from normal neural tissue, and then different lengths of scars ranging from 0.5-4.5 cm were surgically resected in five complete chronic spinal cord injury （SCI） patients. The NeuroRegen scaffold along with autologous bone marrow mononuclear cells （BMMCs）, which have been proven to promote neural regeneration and SCI recovery in animal models, were transplanted into the gap in the spinal cord following scar tissue resection. No obvious adverse effects related to scar resection or NeuroRegen scaffold transplantation were observed immediately after surgery or at the 12-month follow-up. In addition, patients showed partially autonomic nervous function improvement, and the recovery of somatosensory evoked potentials （SSEP） from the lower limbs was also detected. The results indicate that scar resection and NeuroRegen scaffold transplantation could be a promising clinical approach to treating SCI.</description><subject>Adult</subject><subject>Biomedical and Life Sciences</subject><subject>Cicatrix - surgery</subject><subject>Cover Article</subject><subject>Female</subject><subject>Humans</subject><subject>Life Sciences</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Nerve Regeneration</subject><subject>Spinal Cord Injuries - physiopathology</subject><subject>Spinal Cord Injuries - surgery</subject><subject>Tissue Scaffolds</subject><subject>Treatment Outcome</subject><subject>临床</subject><subject>患者</subject><subject>慢性</subject><subject>支架</subject><subject>瘢痕</subject><subject>神经组织</subject><subject>脊髓损伤</subject><subject>骨髓单个核细胞</subject><issn>1674-7305</issn><issn>1869-1889</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNqNkU1r3DAQhk1paUKaH9BLEe2lFzX6sD3SsYR-BEIDIT0bWx5tvHglR7Ipm3N_eGezm1B6KNFFQvPMoxFvUbyV4pMUAs6ylKUCLmTNK2EEv39RHEtTWy6NsS_pXEPJQYvqqDjNeS1oaS0UwOviSIHWGkx1XPy-Csi32CbmxiEMrh1Znpd-y6JnP3BJ8RpXGFh2rfdx7NmwmcY2zO08xMDoZoy_hrDa1RNLmNE9FIbAXCQSZ2TuNkUSszwNgewuJrKE9ZK2bCINhjm_KV75dsx4ethPip9fv9ycf-eXV98uzj9fcleVcuYllK3wnTGgNHhlhRWq85VqrQNRVT2CMwh1J2wFsuxM75x3oJRyHmovUZ8UH_feKcW7BfPcbIbscKQfYVxyI40gN9RWPAdVJahaVYR--AddxyXRXx8oaRQNB0TJPeVSzDmhb6Y0bNq0baRodoE2-0AbCrTZBdrcU8-7g3npNtg_dTzGR4DaA5lKYYXpr6f_Y31_mOQ2htUd9T2J69qWYJXV-g-QV7hp</recordid><startdate>20160701</startdate><enddate>20160701</enddate><creator>Xiao, Zhifeng</creator><creator>Tang, Fengwu</creator><creator>Tang, Jiaguang</creator><creator>Yang, Huilin</creator><creator>Zhao, Yannan</creator><creator>Chen, Bing</creator><creator>Han, Sufang</creator><creator>Wang, Nuo</creator><creator>Li, Xing</creator><creator>Cheng, Shixiang</creator><creator>Han, Guang</creator><creator>Zhao, Changyu</creator><creator>Yang, Xiaoxiong</creator><creator>Chen, Yumei</creator><creator>Shi, Qin</creator><creator>Hou, Shuxun</creator><creator>Zhang, Sai</creator><creator>Dai, Jianwu</creator><general>Science China Press</general><general>Springer Nature B.V</general><scope>2RA</scope><scope>92L</scope><scope>CQIGP</scope><scope>~WA</scope><scope>C6C</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7TK</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>8AO</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20160701</creationdate><title>One-year clinical study of NeuroRegen scaffold implantation following scar resection in complete chronic spinal cord injury patients</title><author>Xiao, Zhifeng ; 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China Life Sci</stitle><addtitle>Sci China Life Sci</addtitle><date>2016-07-01</date><risdate>2016</risdate><volume>59</volume><issue>7</issue><spage>647</spage><epage>655</epage><pages>647-655</pages><issn>1674-7305</issn><eissn>1869-1889</eissn><abstract>The objective of this clinical study was to assess the safety and feasibility of the collagen scaffold, NeuroRegen scaffold, one year after scar tissue resection and implantation. Scar tissue is a physical and chemical barrier that prevents neural regeneration However, identification of scar tissue is still a major challenge. In this study, the nerve electrophysiology method was used to distinguish scar tissue from normal neural tissue, and then different lengths of scars ranging from 0.5-4.5 cm were surgically resected in five complete chronic spinal cord injury （SCI） patients. The NeuroRegen scaffold along with autologous bone marrow mononuclear cells （BMMCs）, which have been proven to promote neural regeneration and SCI recovery in animal models, were transplanted into the gap in the spinal cord following scar tissue resection. No obvious adverse effects related to scar resection or NeuroRegen scaffold transplantation were observed immediately after surgery or at the 12-month follow-up. In addition, patients showed partially autonomic nervous function improvement, and the recovery of somatosensory evoked potentials （SSEP） from the lower limbs was also detected. The results indicate that scar resection and NeuroRegen scaffold transplantation could be a promising clinical approach to treating SCI.</abstract><cop>Beijing</cop><pub>Science China Press</pub><pmid>27333785</pmid><doi>10.1007/s11427-016-5080-z</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Science China. Life sciences, 2016-07, Vol.59 (7), p.647-655 |
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| subjects | Adult Biomedical and Life Sciences Cicatrix - surgery Cover Article Female Humans Life Sciences Male Middle Aged Nerve Regeneration Spinal Cord Injuries - physiopathology Spinal Cord Injuries - surgery Tissue Scaffolds Treatment Outcome 临床 患者 慢性 支架 瘢痕 神经组织 脊髓损伤 骨髓单个核细胞 |
| title | One-year clinical study of NeuroRegen scaffold implantation following scar resection in complete chronic spinal cord injury patients |
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