Performance characteristics of the simplified version of ankylosing spondylitis disease activity score (SASDAS)
Various types of disease activity measures are available for axial spondyloarthritis (axSpA), and there is no gold standard for all individual patients. The ankylosing spondylitis disease activity score (ASDAS) is highly discriminatory, sensitive to change, and associated with structural progression...
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| Veröffentlicht in: | Clinical rheumatology 2016-07, Vol.35 (7), p.1753-1758 |
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| creator | Solmaz, Dilek Yildirim, Tulay Avci, Okan Tomas, Nazmiye Akar, Servet |
| description | Various types of disease activity measures are available for axial spondyloarthritis (axSpA), and there is no gold standard for all individual patients. The ankylosing spondylitis disease activity score (ASDAS) is highly discriminatory, sensitive to change, and associated with structural progression. A simplified version of the ASDAS (SASDAS) was proposed and found to be a simple and practical tool to assess disease activity. Our aim was to test the performance characteristics of the SASDAS and compare it with validated tools. In total, 97 consecutive ankylosing spondylitis (AS) patients were included in the study. Disease activity was assessed by the ASDAS-erythrocyte sedimentation rate (ESR), ASDAS-C-reactive protein (CRP), bath ankylosing spondylitis disease activity index (BASDAI), and SASDAS. The relationship among these activity indices and the level of agreement of various activity categories were tested. There was a strong correlation between the SASDAS and other activity indices, including the BASDAI (
r
= 0.916,
p
|
| doi_str_mv | 10.1007/s10067-015-3147-z |
| format | Article |
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r
= 0.916,
p
< 0.001), ASDAS-CRP (
r
= 0.847,
p
< 0.001), and ASDAS-ESR (
r
= 0.942,
p
< 0.001). Although the agreement between the ASDAS-ESR and SASDAS was good (weighted kappa of 0.744 and total agreement of 77 %), there was moderate agreement between the ASDAS-CRP and SASDAS (weighted kappa of 0.579 and total agreement of 66 %). The disagreement was particularly striking in “moderate” and “high disease activity” states. Approximately 40 % of patients classified as moderate activity according to the ASDAS-ESR and 45 % according to the ASDAS-CRP were differentially categorized by the SASDAS. The results of the present analysis suggest that the simplified version of the ASDAS-ESR should be further validated in various settings and populations due to a questionable level of agreement between the ASDAS-CRP and SASDAS.</description><identifier>ISSN: 0770-3198</identifier><identifier>EISSN: 1434-9949</identifier><identifier>DOI: 10.1007/s10067-015-3147-z</identifier><identifier>PMID: 26670454</identifier><language>eng</language><publisher>London: Springer London</publisher><subject>Adult ; Blood Sedimentation ; C-Reactive Protein - analysis ; Disease Progression ; Female ; Humans ; Male ; Medicine ; Medicine & Public Health ; Middle Aged ; Original Article ; Quality of Life ; Rheumatology ; Severity of Illness Index ; Spondylitis, Ankylosing - diagnosis ; Spondylitis, Ankylosing - physiopathology ; Surveys and Questionnaires ; Turkey</subject><ispartof>Clinical rheumatology, 2016-07, Vol.35 (7), p.1753-1758</ispartof><rights>International League of Associations for Rheumatology (ILAR) 2015</rights><rights>International League of Associations for Rheumatology (ILAR) 2016</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c405t-43a2f5076a3ebdbfc08b01c30f850dd82dce57126175e39e99778f47b80a61c3</citedby><cites>FETCH-LOGICAL-c405t-43a2f5076a3ebdbfc08b01c30f850dd82dce57126175e39e99778f47b80a61c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10067-015-3147-z$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10067-015-3147-z$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26670454$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Solmaz, Dilek</creatorcontrib><creatorcontrib>Yildirim, Tulay</creatorcontrib><creatorcontrib>Avci, Okan</creatorcontrib><creatorcontrib>Tomas, Nazmiye</creatorcontrib><creatorcontrib>Akar, Servet</creatorcontrib><title>Performance characteristics of the simplified version of ankylosing spondylitis disease activity score (SASDAS)</title><title>Clinical rheumatology</title><addtitle>Clin Rheumatol</addtitle><addtitle>Clin Rheumatol</addtitle><description>Various types of disease activity measures are available for axial spondyloarthritis (axSpA), and there is no gold standard for all individual patients. The ankylosing spondylitis disease activity score (ASDAS) is highly discriminatory, sensitive to change, and associated with structural progression. A simplified version of the ASDAS (SASDAS) was proposed and found to be a simple and practical tool to assess disease activity. Our aim was to test the performance characteristics of the SASDAS and compare it with validated tools. In total, 97 consecutive ankylosing spondylitis (AS) patients were included in the study. Disease activity was assessed by the ASDAS-erythrocyte sedimentation rate (ESR), ASDAS-C-reactive protein (CRP), bath ankylosing spondylitis disease activity index (BASDAI), and SASDAS. The relationship among these activity indices and the level of agreement of various activity categories were tested. There was a strong correlation between the SASDAS and other activity indices, including the BASDAI (
r
= 0.916,
p
< 0.001), ASDAS-CRP (
r
= 0.847,
p
< 0.001), and ASDAS-ESR (
r
= 0.942,
p
< 0.001). Although the agreement between the ASDAS-ESR and SASDAS was good (weighted kappa of 0.744 and total agreement of 77 %), there was moderate agreement between the ASDAS-CRP and SASDAS (weighted kappa of 0.579 and total agreement of 66 %). The disagreement was particularly striking in “moderate” and “high disease activity” states. Approximately 40 % of patients classified as moderate activity according to the ASDAS-ESR and 45 % according to the ASDAS-CRP were differentially categorized by the SASDAS. The results of the present analysis suggest that the simplified version of the ASDAS-ESR should be further validated in various settings and populations due to a questionable level of agreement between the ASDAS-CRP and SASDAS.</description><subject>Adult</subject><subject>Blood Sedimentation</subject><subject>C-Reactive Protein - analysis</subject><subject>Disease Progression</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Original Article</subject><subject>Quality of Life</subject><subject>Rheumatology</subject><subject>Severity of Illness Index</subject><subject>Spondylitis, Ankylosing - diagnosis</subject><subject>Spondylitis, Ankylosing - physiopathology</subject><subject>Surveys and Questionnaires</subject><subject>Turkey</subject><issn>0770-3198</issn><issn>1434-9949</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNqFkV1rFDEUhoModq3-AG8k4E29GD3JfCS5XFq_oKCwvQ-ZzEmbOjNZc2YL219v1q0igniTXLzPecPJw9hLAW8FgHpH5exUBaKtatGo6v4RW4mmbipjGvOYrUApKInRJ-wZ0S0ASG3EU3Yiu05B0zYrlr5iDilPbvbI_Y3Lzi-YIy3RE0-BLzfIKU7bMYaIA7_DTDHNh8TN3_Zjojhfc9qmediPcYnEh0joCHnpiXdx2XPyKSM_26w3F-vNm-fsSXAj4YuH-5RdfXh_df6puvzy8fP5-rLyDbRL1dROhhZU52rshz540D0IX0PQLQyDloPHVgnZCdVibdAYpXRoVK_BdYU7ZWfH2m1O33dIi50ieRxHN2PakRUatJKdker_qDK6_KeUpqCv_0Jv0y7PZY-flARhpCyUOFI-J6KMwW5znFzeWwH24M0evdnizR682fsy8-qheddPOPye-CWqAPIIUInma8x_PP3P1h_1caO4</recordid><startdate>20160701</startdate><enddate>20160701</enddate><creator>Solmaz, Dilek</creator><creator>Yildirim, Tulay</creator><creator>Avci, Okan</creator><creator>Tomas, Nazmiye</creator><creator>Akar, Servet</creator><general>Springer London</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7T5</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20160701</creationdate><title>Performance characteristics of the simplified version of ankylosing spondylitis disease activity score (SASDAS)</title><author>Solmaz, Dilek ; Yildirim, Tulay ; Avci, Okan ; Tomas, Nazmiye ; Akar, Servet</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c405t-43a2f5076a3ebdbfc08b01c30f850dd82dce57126175e39e99778f47b80a61c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Adult</topic><topic>Blood Sedimentation</topic><topic>C-Reactive Protein - analysis</topic><topic>Disease Progression</topic><topic>Female</topic><topic>Humans</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Original Article</topic><topic>Quality of Life</topic><topic>Rheumatology</topic><topic>Severity of Illness Index</topic><topic>Spondylitis, Ankylosing - diagnosis</topic><topic>Spondylitis, Ankylosing - physiopathology</topic><topic>Surveys and Questionnaires</topic><topic>Turkey</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Solmaz, Dilek</creatorcontrib><creatorcontrib>Yildirim, Tulay</creatorcontrib><creatorcontrib>Avci, Okan</creatorcontrib><creatorcontrib>Tomas, Nazmiye</creatorcontrib><creatorcontrib>Akar, Servet</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Immunology Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical rheumatology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Solmaz, Dilek</au><au>Yildirim, Tulay</au><au>Avci, Okan</au><au>Tomas, Nazmiye</au><au>Akar, Servet</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Performance characteristics of the simplified version of ankylosing spondylitis disease activity score (SASDAS)</atitle><jtitle>Clinical rheumatology</jtitle><stitle>Clin Rheumatol</stitle><addtitle>Clin Rheumatol</addtitle><date>2016-07-01</date><risdate>2016</risdate><volume>35</volume><issue>7</issue><spage>1753</spage><epage>1758</epage><pages>1753-1758</pages><issn>0770-3198</issn><eissn>1434-9949</eissn><abstract>Various types of disease activity measures are available for axial spondyloarthritis (axSpA), and there is no gold standard for all individual patients. The ankylosing spondylitis disease activity score (ASDAS) is highly discriminatory, sensitive to change, and associated with structural progression. A simplified version of the ASDAS (SASDAS) was proposed and found to be a simple and practical tool to assess disease activity. Our aim was to test the performance characteristics of the SASDAS and compare it with validated tools. In total, 97 consecutive ankylosing spondylitis (AS) patients were included in the study. Disease activity was assessed by the ASDAS-erythrocyte sedimentation rate (ESR), ASDAS-C-reactive protein (CRP), bath ankylosing spondylitis disease activity index (BASDAI), and SASDAS. The relationship among these activity indices and the level of agreement of various activity categories were tested. There was a strong correlation between the SASDAS and other activity indices, including the BASDAI (
r
= 0.916,
p
< 0.001), ASDAS-CRP (
r
= 0.847,
p
< 0.001), and ASDAS-ESR (
r
= 0.942,
p
< 0.001). Although the agreement between the ASDAS-ESR and SASDAS was good (weighted kappa of 0.744 and total agreement of 77 %), there was moderate agreement between the ASDAS-CRP and SASDAS (weighted kappa of 0.579 and total agreement of 66 %). The disagreement was particularly striking in “moderate” and “high disease activity” states. Approximately 40 % of patients classified as moderate activity according to the ASDAS-ESR and 45 % according to the ASDAS-CRP were differentially categorized by the SASDAS. The results of the present analysis suggest that the simplified version of the ASDAS-ESR should be further validated in various settings and populations due to a questionable level of agreement between the ASDAS-CRP and SASDAS.</abstract><cop>London</cop><pub>Springer London</pub><pmid>26670454</pmid><doi>10.1007/s10067-015-3147-z</doi><tpages>6</tpages></addata></record> |
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| ispartof | Clinical rheumatology, 2016-07, Vol.35 (7), p.1753-1758 |
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| source | MEDLINE; Springer Nature - Complete Springer Journals |
| subjects | Adult Blood Sedimentation C-Reactive Protein - analysis Disease Progression Female Humans Male Medicine Medicine & Public Health Middle Aged Original Article Quality of Life Rheumatology Severity of Illness Index Spondylitis, Ankylosing - diagnosis Spondylitis, Ankylosing - physiopathology Surveys and Questionnaires Turkey |
| title | Performance characteristics of the simplified version of ankylosing spondylitis disease activity score (SASDAS) |
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