Predominant development of mature and functional human NK cells in a novel human IL-2-producing transgenic NOG mouse

We generated a severe immunodeficient NOD/Shi-scid-IL-2Rγ(null) (NOG) mouse substrain expressing the transgenic human IL-2 gene (NOG-IL-2 Tg). Upon transfer of human cord blood-derived hematopoietic stem cells (HSCs), CD3(-)CD56(high)CD16(+/-) cells developed unexpectedly, predominantly in the NOG-I...

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Veröffentlicht in:	The Journal of immunology (1950) 2015-04, Vol.194 (7), p.3513-3525
Hauptverfasser:	Katano, Ikumi, Takahashi, Takeshi, Ito, Ryoji, Kamisako, Tsutomu, Mizusawa, Takuma, Ka, Yuyo, Ogura, Tomoyuki, Suemizu, Hiroshi, Kawakami, Yutaka, Ito, Mamoru
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibody-Dependent Cell Cytotoxicity Antigens, Surface - metabolism Cell Differentiation Cytotoxicity, Immunologic Disease Models, Animal Hematopoietic Stem Cell Transplantation Hematopoietic Stem Cells - cytology Hematopoietic Stem Cells - metabolism Humans Immunophenotyping Interleukin-2 - biosynthesis Interleukin-2 - genetics Killer Cells, Natural - cytology Killer Cells, Natural - immunology Killer Cells, Natural - metabolism Mice Mice, Transgenic Neoplasms - genetics Neoplasms - immunology Neoplasms - metabolism Neoplasms - pathology Phenotype Receptors, KIR - genetics Receptors, KIR - metabolism
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