CD4 T cells specific for a latency-associated γ-herpesvirus epitope are polyfunctional and cytotoxic

The oncogenic γ-herpesviruses EBV and Kaposi sarcoma-associated herpesvirus are ubiquitous human pathogens that establish lifelong latent infections maintained by intermittent viral reactivation and reinfection. Effector CD4 T cells are critical for control of viral latency and in immune therapies f...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	The Journal of immunology (1950) 2014-12, Vol.193 (12), p.5827-5834
Hauptverfasser:	Freeman, Michael L, Burkum, Claire E, Cookenham, Tres, Roberts, Alan D, Lanzer, Kathleen G, Huston, Gail E, Jensen, Meghan K, Sidney, John, Peters, Bjoern, Kohlmeier, Jacob E, Woodland, David L, van Dyk, Linda F, Sette, Alessandro, Blackman, Marcia A
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals CD4-Positive T-Lymphocytes - immunology CD4-Positive T-Lymphocytes - metabolism Cytokines - biosynthesis Cytotoxicity, Immunologic Epitopes, T-Lymphocyte - chemistry Epitopes, T-Lymphocyte - immunology Epstein-Barr virus Gammaherpesvirinae - immunology Herpesviridae Infections - immunology Herpesviridae Infections - virology Herpesvirus Interferon-gamma - biosynthesis Lymphocyte Activation - immunology Mice Molecular Sequence Data Peptides - chemistry Peptides - immunology T-Cell Antigen Receptor Specificity - immunology Virus Latency
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!