Double oral esomeprazole after a 3-day intravenous esomeprazole infusion reduces recurrent peptic ulcer bleeding in high-risk patients: a randomised controlled study
Background Patients with high Rockall scores have increased risk of ulcer rebleeding after 3-day esomeprazole infusions. Objective To investigate whether double oral esomeprazole given after a 3-day esomeprazole infusion decreases ulcer rebleeding for patients with high Rockall scores. Design We pro...
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| Veröffentlicht in: | Gut 2014-12, Vol.63 (12), p.1864-1872 |
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| creator | Cheng, Hsiu-Chi Wu, Chung-Tai Chang, Wei-Lun Cheng, Wei-Chun Chen, Wei-Ying Sheu, Bor-Shyang |
| description | Background Patients with high Rockall scores have increased risk of ulcer rebleeding after 3-day esomeprazole infusions. Objective To investigate whether double oral esomeprazole given after a 3-day esomeprazole infusion decreases ulcer rebleeding for patients with high Rockall scores. Design We prospectively enrolled 293 patients with peptic ulcer bleeding who had achieved endoscopic haemostasis. After a 3-day esomeprazole infusion, patients with Rockall scores ≥6 were randomised into the oral double-dose group (n=93) or the oral standard-dose group (n=94) to receive 11 days of oral esomeprazole 40 mg twice daily or once daily, respectively. The patients with Rockall scores |
| doi_str_mv | 10.1136/gutjnl-2013-306531 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1808720716</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1619318195</sourcerecordid><originalsourceid>FETCH-LOGICAL-b472t-72dc6be1f056b84d4593c551f3ccbc5de99ba8793e277b392b45371164dfdb533</originalsourceid><addsrcrecordid>eNqNkUuLFDEUhYMoTjv6B1xIwI2baFJ5u5PxCQNudF3kVT1pq5MyqQy0_8f_acYaBd3o6obwnXPu5QDwmODnhFDxYt_WQ5rRgAlFFAtOyR2wI0woRAel7oIdxkQiLpk-Aw9qPWCMldLkPjgbmOCKa7UD31_nZucAczEzDDUfw1LMt9x_zLSGAg2kyJsTjGkt5jqk3OqfWExTqzEnWIJvLtQ-XSslpBUuYVmjg2123aiHBB_TvgvgVdxfoRLrF7iYNXa0vuxBxSSfj7EGD13ucXme-7OuzZ8egnuTmWt4dDvPwee3bz5dvEeXH999uHh1iSyTw4rk4J2wgUyYC6uYZ1xTxzmZqHPWcR-0tkZJTcMgpaV6sIxTSYhgfvKWU3oOnm2-S8lfW6jr2PdxYZ5NCv3ykSis5IAlEf9GBdGUKKJ5R5_-hR5yK6kfMhIpNRNM_6SGjXIl11rCNC4lHk05jQSPN32PW9_jTd_j1ncXPbm1bvYY_G_Jr4I7gDbAHg__Y_gDpCG5cQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1779464995</pqid></control><display><type>article</type><title>Double oral esomeprazole after a 3-day intravenous esomeprazole infusion reduces recurrent peptic ulcer bleeding in high-risk patients: a randomised controlled study</title><source>MEDLINE</source><source>BMJ Journals - NESLi2</source><source>PubMed Central</source><creator>Cheng, Hsiu-Chi ; Wu, Chung-Tai ; Chang, Wei-Lun ; Cheng, Wei-Chun ; Chen, Wei-Ying ; Sheu, Bor-Shyang</creator><creatorcontrib>Cheng, Hsiu-Chi ; Wu, Chung-Tai ; Chang, Wei-Lun ; Cheng, Wei-Chun ; Chen, Wei-Ying ; Sheu, Bor-Shyang</creatorcontrib><description>Background Patients with high Rockall scores have increased risk of ulcer rebleeding after 3-day esomeprazole infusions. Objective To investigate whether double oral esomeprazole given after a 3-day esomeprazole infusion decreases ulcer rebleeding for patients with high Rockall scores. Design We prospectively enrolled 293 patients with peptic ulcer bleeding who had achieved endoscopic haemostasis. After a 3-day esomeprazole infusion, patients with Rockall scores ≥6 were randomised into the oral double-dose group (n=93) or the oral standard-dose group (n=94) to receive 11 days of oral esomeprazole 40 mg twice daily or once daily, respectively. The patients with Rockall scores <6 served as controls (n=89); they received 11 days of oral esomeprazole 40 mg once daily. Thereafter, all patients received oral esomeprazole 40 mg once daily for two more weeks until the end of the 28-day study period. The primary end point was peptic ulcer rebleeding. Results Among patients with Rockall scores ≥6, the oral double-dose group had a higher cumulative rebleeding-free proportion than the oral standard-dose group (p=0.02, log-rank test). The proportion of patients free from recurrent bleeding during the 4th–28th day in the oral double-dose group remained lower than that of the group with Rockall scores <6 (p=0.03, log-rank test). Among patients with Rockall scores ≥6, the rebleeding rate was lower in the oral double-dose group than in the oral standard-dose group (4th–28th day: 10.8% vs 28.7%, p=0.002). Conclusions Double oral esomeprazole at 40 mg twice daily after esomeprazole infusion reduced recurrent peptic ulcer bleeding in high-risk patients with Rockall scores ≥6. Trial registration number NCT01591083.</description><identifier>ISSN: 0017-5749</identifier><identifier>EISSN: 1468-3288</identifier><identifier>DOI: 10.1136/gutjnl-2013-306531</identifier><identifier>PMID: 24658598</identifier><identifier>CODEN: GUTTAK</identifier><language>eng</language><publisher>England: BMJ Publishing Group LTD</publisher><subject>Administration, Oral ; Adult ; Aged ; Bias ; Dose-Response Relationship, Drug ; Drug Administration Schedule ; Drug dosages ; Duodenal Ulcer - complications ; Duodenal Ulcer - diagnosis ; Duodenal Ulcer - physiopathology ; Endoscopy ; Esomeprazole - administration & dosage ; Female ; Hemostasis, Endoscopic - methods ; Humans ; Infusions, Intravenous ; Male ; Middle Aged ; Mortality ; Ostomy ; Patients ; Peptic Ulcer Hemorrhage - diagnosis ; Peptic Ulcer Hemorrhage - etiology ; Peptic Ulcer Hemorrhage - physiopathology ; Peptic Ulcer Hemorrhage - therapy ; Prescription drugs ; Proton Pump Inhibitors - administration & dosage ; Protons ; Secondary Prevention ; Severity of Illness Index ; Stomach Ulcer - complications ; Stomach Ulcer - diagnosis ; Stomach Ulcer - physiopathology ; Studies ; Treatment Outcome ; Ulcers</subject><ispartof>Gut, 2014-12, Vol.63 (12), p.1864-1872</ispartof><rights>Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions</rights><rights>Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.</rights><rights>Copyright: 2014 Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b472t-72dc6be1f056b84d4593c551f3ccbc5de99ba8793e277b392b45371164dfdb533</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttp://gut.bmj.com/content/63/12/1864.full.pdf$$EPDF$$P50$$Gbmj$$H</linktopdf><linktohtml>$$Uhttp://gut.bmj.com/content/63/12/1864.full$$EHTML$$P50$$Gbmj$$H</linktohtml><link.rule.ids>114,115,314,777,781,3183,23552,27905,27906,77349,77380</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24658598$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Cheng, Hsiu-Chi</creatorcontrib><creatorcontrib>Wu, Chung-Tai</creatorcontrib><creatorcontrib>Chang, Wei-Lun</creatorcontrib><creatorcontrib>Cheng, Wei-Chun</creatorcontrib><creatorcontrib>Chen, Wei-Ying</creatorcontrib><creatorcontrib>Sheu, Bor-Shyang</creatorcontrib><title>Double oral esomeprazole after a 3-day intravenous esomeprazole infusion reduces recurrent peptic ulcer bleeding in high-risk patients: a randomised controlled study</title><title>Gut</title><addtitle>Gut</addtitle><description>Background Patients with high Rockall scores have increased risk of ulcer rebleeding after 3-day esomeprazole infusions. Objective To investigate whether double oral esomeprazole given after a 3-day esomeprazole infusion decreases ulcer rebleeding for patients with high Rockall scores. Design We prospectively enrolled 293 patients with peptic ulcer bleeding who had achieved endoscopic haemostasis. After a 3-day esomeprazole infusion, patients with Rockall scores ≥6 were randomised into the oral double-dose group (n=93) or the oral standard-dose group (n=94) to receive 11 days of oral esomeprazole 40 mg twice daily or once daily, respectively. The patients with Rockall scores <6 served as controls (n=89); they received 11 days of oral esomeprazole 40 mg once daily. Thereafter, all patients received oral esomeprazole 40 mg once daily for two more weeks until the end of the 28-day study period. The primary end point was peptic ulcer rebleeding. Results Among patients with Rockall scores ≥6, the oral double-dose group had a higher cumulative rebleeding-free proportion than the oral standard-dose group (p=0.02, log-rank test). The proportion of patients free from recurrent bleeding during the 4th–28th day in the oral double-dose group remained lower than that of the group with Rockall scores <6 (p=0.03, log-rank test). Among patients with Rockall scores ≥6, the rebleeding rate was lower in the oral double-dose group than in the oral standard-dose group (4th–28th day: 10.8% vs 28.7%, p=0.002). Conclusions Double oral esomeprazole at 40 mg twice daily after esomeprazole infusion reduced recurrent peptic ulcer bleeding in high-risk patients with Rockall scores ≥6. Trial registration number NCT01591083.</description><subject>Administration, Oral</subject><subject>Adult</subject><subject>Aged</subject><subject>Bias</subject><subject>Dose-Response Relationship, Drug</subject><subject>Drug Administration Schedule</subject><subject>Drug dosages</subject><subject>Duodenal Ulcer - complications</subject><subject>Duodenal Ulcer - diagnosis</subject><subject>Duodenal Ulcer - physiopathology</subject><subject>Endoscopy</subject><subject>Esomeprazole - administration & dosage</subject><subject>Female</subject><subject>Hemostasis, Endoscopic - methods</subject><subject>Humans</subject><subject>Infusions, Intravenous</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Mortality</subject><subject>Ostomy</subject><subject>Patients</subject><subject>Peptic Ulcer Hemorrhage - diagnosis</subject><subject>Peptic Ulcer Hemorrhage - etiology</subject><subject>Peptic Ulcer Hemorrhage - physiopathology</subject><subject>Peptic Ulcer Hemorrhage - therapy</subject><subject>Prescription drugs</subject><subject>Proton Pump Inhibitors - administration & dosage</subject><subject>Protons</subject><subject>Secondary Prevention</subject><subject>Severity of Illness Index</subject><subject>Stomach Ulcer - complications</subject><subject>Stomach Ulcer - diagnosis</subject><subject>Stomach Ulcer - physiopathology</subject><subject>Studies</subject><subject>Treatment Outcome</subject><subject>Ulcers</subject><issn>0017-5749</issn><issn>1468-3288</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqNkUuLFDEUhYMoTjv6B1xIwI2baFJ5u5PxCQNudF3kVT1pq5MyqQy0_8f_acYaBd3o6obwnXPu5QDwmODnhFDxYt_WQ5rRgAlFFAtOyR2wI0woRAel7oIdxkQiLpk-Aw9qPWCMldLkPjgbmOCKa7UD31_nZucAczEzDDUfw1LMt9x_zLSGAg2kyJsTjGkt5jqk3OqfWExTqzEnWIJvLtQ-XSslpBUuYVmjg2123aiHBB_TvgvgVdxfoRLrF7iYNXa0vuxBxSSfj7EGD13ucXme-7OuzZ8egnuTmWt4dDvPwee3bz5dvEeXH999uHh1iSyTw4rk4J2wgUyYC6uYZ1xTxzmZqHPWcR-0tkZJTcMgpaV6sIxTSYhgfvKWU3oOnm2-S8lfW6jr2PdxYZ5NCv3ykSis5IAlEf9GBdGUKKJ5R5_-hR5yK6kfMhIpNRNM_6SGjXIl11rCNC4lHk05jQSPN32PW9_jTd_j1ncXPbm1bvYY_G_Jr4I7gDbAHg__Y_gDpCG5cQ</recordid><startdate>20141201</startdate><enddate>20141201</enddate><creator>Cheng, Hsiu-Chi</creator><creator>Wu, Chung-Tai</creator><creator>Chang, Wei-Lun</creator><creator>Cheng, Wei-Chun</creator><creator>Chen, Wei-Ying</creator><creator>Sheu, Bor-Shyang</creator><general>BMJ Publishing Group LTD</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88I</scope><scope>8AF</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>BTHHO</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7X8</scope><scope>7T5</scope><scope>H94</scope></search><sort><creationdate>20141201</creationdate><title>Double oral esomeprazole after a 3-day intravenous esomeprazole infusion reduces recurrent peptic ulcer bleeding in high-risk patients: a randomised controlled study</title><author>Cheng, Hsiu-Chi ; Wu, Chung-Tai ; Chang, Wei-Lun ; Cheng, Wei-Chun ; Chen, Wei-Ying ; Sheu, Bor-Shyang</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b472t-72dc6be1f056b84d4593c551f3ccbc5de99ba8793e277b392b45371164dfdb533</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Administration, Oral</topic><topic>Adult</topic><topic>Aged</topic><topic>Bias</topic><topic>Dose-Response Relationship, Drug</topic><topic>Drug Administration Schedule</topic><topic>Drug dosages</topic><topic>Duodenal Ulcer - complications</topic><topic>Duodenal Ulcer - diagnosis</topic><topic>Duodenal Ulcer - physiopathology</topic><topic>Endoscopy</topic><topic>Esomeprazole - administration & dosage</topic><topic>Female</topic><topic>Hemostasis, Endoscopic - methods</topic><topic>Humans</topic><topic>Infusions, Intravenous</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Mortality</topic><topic>Ostomy</topic><topic>Patients</topic><topic>Peptic Ulcer Hemorrhage - diagnosis</topic><topic>Peptic Ulcer Hemorrhage - etiology</topic><topic>Peptic Ulcer Hemorrhage - physiopathology</topic><topic>Peptic Ulcer Hemorrhage - therapy</topic><topic>Prescription drugs</topic><topic>Proton Pump Inhibitors - administration & dosage</topic><topic>Protons</topic><topic>Secondary Prevention</topic><topic>Severity of Illness Index</topic><topic>Stomach Ulcer - complications</topic><topic>Stomach Ulcer - diagnosis</topic><topic>Stomach Ulcer - physiopathology</topic><topic>Studies</topic><topic>Treatment Outcome</topic><topic>Ulcers</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cheng, Hsiu-Chi</creatorcontrib><creatorcontrib>Wu, Chung-Tai</creatorcontrib><creatorcontrib>Chang, Wei-Lun</creatorcontrib><creatorcontrib>Cheng, Wei-Chun</creatorcontrib><creatorcontrib>Chen, Wei-Ying</creatorcontrib><creatorcontrib>Sheu, Bor-Shyang</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>STEM Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>BMJ Journals</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>Biological Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><jtitle>Gut</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cheng, Hsiu-Chi</au><au>Wu, Chung-Tai</au><au>Chang, Wei-Lun</au><au>Cheng, Wei-Chun</au><au>Chen, Wei-Ying</au><au>Sheu, Bor-Shyang</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Double oral esomeprazole after a 3-day intravenous esomeprazole infusion reduces recurrent peptic ulcer bleeding in high-risk patients: a randomised controlled study</atitle><jtitle>Gut</jtitle><addtitle>Gut</addtitle><date>2014-12-01</date><risdate>2014</risdate><volume>63</volume><issue>12</issue><spage>1864</spage><epage>1872</epage><pages>1864-1872</pages><issn>0017-5749</issn><eissn>1468-3288</eissn><coden>GUTTAK</coden><abstract>Background Patients with high Rockall scores have increased risk of ulcer rebleeding after 3-day esomeprazole infusions. Objective To investigate whether double oral esomeprazole given after a 3-day esomeprazole infusion decreases ulcer rebleeding for patients with high Rockall scores. Design We prospectively enrolled 293 patients with peptic ulcer bleeding who had achieved endoscopic haemostasis. After a 3-day esomeprazole infusion, patients with Rockall scores ≥6 were randomised into the oral double-dose group (n=93) or the oral standard-dose group (n=94) to receive 11 days of oral esomeprazole 40 mg twice daily or once daily, respectively. The patients with Rockall scores <6 served as controls (n=89); they received 11 days of oral esomeprazole 40 mg once daily. Thereafter, all patients received oral esomeprazole 40 mg once daily for two more weeks until the end of the 28-day study period. The primary end point was peptic ulcer rebleeding. Results Among patients with Rockall scores ≥6, the oral double-dose group had a higher cumulative rebleeding-free proportion than the oral standard-dose group (p=0.02, log-rank test). The proportion of patients free from recurrent bleeding during the 4th–28th day in the oral double-dose group remained lower than that of the group with Rockall scores <6 (p=0.03, log-rank test). Among patients with Rockall scores ≥6, the rebleeding rate was lower in the oral double-dose group than in the oral standard-dose group (4th–28th day: 10.8% vs 28.7%, p=0.002). Conclusions Double oral esomeprazole at 40 mg twice daily after esomeprazole infusion reduced recurrent peptic ulcer bleeding in high-risk patients with Rockall scores ≥6. Trial registration number NCT01591083.</abstract><cop>England</cop><pub>BMJ Publishing Group LTD</pub><pmid>24658598</pmid><doi>10.1136/gutjnl-2013-306531</doi><tpages>9</tpages></addata></record> |
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| ispartof | Gut, 2014-12, Vol.63 (12), p.1864-1872 |
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| subjects | Administration, Oral Adult Aged Bias Dose-Response Relationship, Drug Drug Administration Schedule Drug dosages Duodenal Ulcer - complications Duodenal Ulcer - diagnosis Duodenal Ulcer - physiopathology Endoscopy Esomeprazole - administration & dosage Female Hemostasis, Endoscopic - methods Humans Infusions, Intravenous Male Middle Aged Mortality Ostomy Patients Peptic Ulcer Hemorrhage - diagnosis Peptic Ulcer Hemorrhage - etiology Peptic Ulcer Hemorrhage - physiopathology Peptic Ulcer Hemorrhage - therapy Prescription drugs Proton Pump Inhibitors - administration & dosage Protons Secondary Prevention Severity of Illness Index Stomach Ulcer - complications Stomach Ulcer - diagnosis Stomach Ulcer - physiopathology Studies Treatment Outcome Ulcers |
| title | Double oral esomeprazole after a 3-day intravenous esomeprazole infusion reduces recurrent peptic ulcer bleeding in high-risk patients: a randomised controlled study |
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