Prevalence of Human Immunodeficiency Virus, Hepatitis B Virus, and Hepatitis C Virus Infections Among Transgender Persons Referred to an Italian Center for Total Sex Reassignment Surgery

INTRODUCTIONThe burden of human immunodeficiency virus (HIV), hepatitis B virus (HBV), and hepatitis C virus (HCV) infections in transgender population is an underestimated issue. We performed a study to evaluate the prevalence of such infections in transgender persons addressed our center for total...

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Veröffentlicht in:Sexually transmitted diseases 2016-07, Vol.43 (7), p.407-411
Hauptverfasser: Luzzati, Roberto, Zatta, Marta, Pavan, Nicola, Serafin, Maurizia, Maurel, Cristina, Trombetta, Carlo, Barbone, Fabio
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container_end_page 411
container_issue 7
container_start_page 407
container_title Sexually transmitted diseases
container_volume 43
creator Luzzati, Roberto
Zatta, Marta
Pavan, Nicola
Serafin, Maurizia
Maurel, Cristina
Trombetta, Carlo
Barbone, Fabio
description INTRODUCTIONThe burden of human immunodeficiency virus (HIV), hepatitis B virus (HBV), and hepatitis C virus (HCV) infections in transgender population is an underestimated issue. We performed a study to evaluate the prevalence of such infections in transgender persons addressed our center for total sex reassignment surgery (SRS). MATERIALS AND METHODSAll transgender persons undergoing SRS from 2000 to 2014 were evaluated retrospectively. Participant characteristics and results of HIV, HBV, and HCV testing were collected. Exact Fisher test, Cochran-Armitage tests for trend and correct prevalence ratios were estimated. RESULTSAmong 498 transgender persons, 243 had confirmed serological data. Of them, 25 were female-to-male and 218 male-to-female (MtF) subjects. The prevalence of HIV, HBV and HCV infections was 0%, 4.0%, and 8.0% in female-to-male, and 12.1%, 4.6%, and 3.7% in MtF. Among MtF, younger age and earlier year of SRS were associated with lower HIV prevalence. From the multivariate model, the mutually adjustment prevalence ratios were 1.9 (95% confidence interval [95% CI], 1.2–3.1) for SRS in 2005–2010 and 3.6 (95% CI, 1.3–9.4) in 2010–2014, as compared with SRS in 2000–2004; and 4.7 (95% CI, 2.4–9.4) for South Americans as compared with others. Among the HCV-positive MtF, 57.1% were also HIV-positive. Regarding HBV, the immunity was 38.5% and, after mutual adjustment, the prevalence ratios were 2.1 (95% CI, 1.3–3.4) for South Americans versus others and 2.2 (95% CI, 1.6–3.1) for year of birth ≥ 1980. DISCUSSIONThe prevalence of HBV and HCV infections among our transgender persons overlaps that reported in the general population, but HCV prevalence was much higher in HIV-infected MtF. The high burden of HIV infection among MtF and its recent incremented prevalence points out that social and medical support should be strongly promoted in such population.
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We performed a study to evaluate the prevalence of such infections in transgender persons addressed our center for total sex reassignment surgery (SRS). MATERIALS AND METHODSAll transgender persons undergoing SRS from 2000 to 2014 were evaluated retrospectively. Participant characteristics and results of HIV, HBV, and HCV testing were collected. Exact Fisher test, Cochran-Armitage tests for trend and correct prevalence ratios were estimated. RESULTSAmong 498 transgender persons, 243 had confirmed serological data. Of them, 25 were female-to-male and 218 male-to-female (MtF) subjects. The prevalence of HIV, HBV and HCV infections was 0%, 4.0%, and 8.0% in female-to-male, and 12.1%, 4.6%, and 3.7% in MtF. Among MtF, younger age and earlier year of SRS were associated with lower HIV prevalence. From the multivariate model, the mutually adjustment prevalence ratios were 1.9 (95% confidence interval [95% CI], 1.2–3.1) for SRS in 2005–2010 and 3.6 (95% CI, 1.3–9.4) in 2010–2014, as compared with SRS in 2000–2004; and 4.7 (95% CI, 2.4–9.4) for South Americans as compared with others. Among the HCV-positive MtF, 57.1% were also HIV-positive. Regarding HBV, the immunity was 38.5% and, after mutual adjustment, the prevalence ratios were 2.1 (95% CI, 1.3–3.4) for South Americans versus others and 2.2 (95% CI, 1.6–3.1) for year of birth ≥ 1980. DISCUSSIONThe prevalence of HBV and HCV infections among our transgender persons overlaps that reported in the general population, but HCV prevalence was much higher in HIV-infected MtF. The high burden of HIV infection among MtF and its recent incremented prevalence points out that social and medical support should be strongly promoted in such population.</description><identifier>ISSN: 0148-5717</identifier><identifier>EISSN: 1537-4521</identifier><identifier>DOI: 10.1097/OLQ.0000000000000452</identifier><identifier>PMID: 27322038</identifier><identifier>CODEN: STRDDM</identifier><language>eng</language><publisher>United States: Lippincott Williams &amp; Wilkins, a business of Wolters Kluwer Health</publisher><subject>Adjustment ; Adult ; Age differences ; Burden ; Childbirth &amp; labor ; Coinfection ; Confidence intervals ; Female ; Health services ; Hepacivirus - immunology ; Hepacivirus - isolation &amp; purification ; Hepatitis ; Hepatitis B ; Hepatitis B - epidemiology ; Hepatitis B - virology ; Hepatitis B virus ; Hepatitis B virus - immunology ; Hepatitis B virus - isolation &amp; purification ; Hepatitis C ; Hepatitis C - epidemiology ; Hepatitis C - virology ; Hepatitis C virus ; HIV ; HIV - immunology ; HIV - isolation &amp; purification ; HIV Infections - epidemiology ; HIV Infections - virology ; HIV Seropositivity ; Human immunodeficiency virus ; Humans ; Immune disorders ; Immunity ; Infections ; Italy - epidemiology ; Lentivirus ; Male ; Medical tests ; Original Study ; Pneumoviridae ; Prevalence ; Racial differences ; Retrospective Studies ; Retroviridae ; Risk factors ; Sex ; Sex change surgery ; Sex Reassignment Surgery ; Sexually transmitted diseases ; STD ; Surgery ; Transgender persons ; Transgender Persons - statistics &amp; numerical data ; Transsexuality ; Viruses</subject><ispartof>Sexually transmitted diseases, 2016-07, Vol.43 (7), p.407-411</ispartof><rights>Copyright © 2016 American Sexually Transmitted Diseases Association</rights><rights>Copyright 2016 American Sexually Transmitted Diseases Association</rights><rights>Copyright Lippincott Williams &amp; Wilkins Jul 2016</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4351-a6a9b3aaa3f131a085281e756f202962f877092e1706362350b00ef9b2d457253</citedby><cites>FETCH-LOGICAL-c4351-a6a9b3aaa3f131a085281e756f202962f877092e1706362350b00ef9b2d457253</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/48512068$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/48512068$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>314,780,784,803,27923,27924,30998,58016,58249</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27322038$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Luzzati, Roberto</creatorcontrib><creatorcontrib>Zatta, Marta</creatorcontrib><creatorcontrib>Pavan, Nicola</creatorcontrib><creatorcontrib>Serafin, Maurizia</creatorcontrib><creatorcontrib>Maurel, Cristina</creatorcontrib><creatorcontrib>Trombetta, Carlo</creatorcontrib><creatorcontrib>Barbone, Fabio</creatorcontrib><title>Prevalence of Human Immunodeficiency Virus, Hepatitis B Virus, and Hepatitis C Virus Infections Among Transgender Persons Referred to an Italian Center for Total Sex Reassignment Surgery</title><title>Sexually transmitted diseases</title><addtitle>Sex Transm Dis</addtitle><description>INTRODUCTIONThe burden of human immunodeficiency virus (HIV), hepatitis B virus (HBV), and hepatitis C virus (HCV) infections in transgender population is an underestimated issue. We performed a study to evaluate the prevalence of such infections in transgender persons addressed our center for total sex reassignment surgery (SRS). MATERIALS AND METHODSAll transgender persons undergoing SRS from 2000 to 2014 were evaluated retrospectively. Participant characteristics and results of HIV, HBV, and HCV testing were collected. Exact Fisher test, Cochran-Armitage tests for trend and correct prevalence ratios were estimated. RESULTSAmong 498 transgender persons, 243 had confirmed serological data. Of them, 25 were female-to-male and 218 male-to-female (MtF) subjects. The prevalence of HIV, HBV and HCV infections was 0%, 4.0%, and 8.0% in female-to-male, and 12.1%, 4.6%, and 3.7% in MtF. Among MtF, younger age and earlier year of SRS were associated with lower HIV prevalence. From the multivariate model, the mutually adjustment prevalence ratios were 1.9 (95% confidence interval [95% CI], 1.2–3.1) for SRS in 2005–2010 and 3.6 (95% CI, 1.3–9.4) in 2010–2014, as compared with SRS in 2000–2004; and 4.7 (95% CI, 2.4–9.4) for South Americans as compared with others. Among the HCV-positive MtF, 57.1% were also HIV-positive. Regarding HBV, the immunity was 38.5% and, after mutual adjustment, the prevalence ratios were 2.1 (95% CI, 1.3–3.4) for South Americans versus others and 2.2 (95% CI, 1.6–3.1) for year of birth ≥ 1980. DISCUSSIONThe prevalence of HBV and HCV infections among our transgender persons overlaps that reported in the general population, but HCV prevalence was much higher in HIV-infected MtF. The high burden of HIV infection among MtF and its recent incremented prevalence points out that social and medical support should be strongly promoted in such population.</description><subject>Adjustment</subject><subject>Adult</subject><subject>Age differences</subject><subject>Burden</subject><subject>Childbirth &amp; labor</subject><subject>Coinfection</subject><subject>Confidence intervals</subject><subject>Female</subject><subject>Health services</subject><subject>Hepacivirus - immunology</subject><subject>Hepacivirus - isolation &amp; purification</subject><subject>Hepatitis</subject><subject>Hepatitis B</subject><subject>Hepatitis B - epidemiology</subject><subject>Hepatitis B - virology</subject><subject>Hepatitis B virus</subject><subject>Hepatitis B virus - immunology</subject><subject>Hepatitis B virus - isolation &amp; purification</subject><subject>Hepatitis C</subject><subject>Hepatitis C - epidemiology</subject><subject>Hepatitis C - virology</subject><subject>Hepatitis C virus</subject><subject>HIV</subject><subject>HIV - immunology</subject><subject>HIV - isolation &amp; 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labor</topic><topic>Coinfection</topic><topic>Confidence intervals</topic><topic>Female</topic><topic>Health services</topic><topic>Hepacivirus - immunology</topic><topic>Hepacivirus - isolation &amp; purification</topic><topic>Hepatitis</topic><topic>Hepatitis B</topic><topic>Hepatitis B - epidemiology</topic><topic>Hepatitis B - virology</topic><topic>Hepatitis B virus</topic><topic>Hepatitis B virus - immunology</topic><topic>Hepatitis B virus - isolation &amp; purification</topic><topic>Hepatitis C</topic><topic>Hepatitis C - epidemiology</topic><topic>Hepatitis C - virology</topic><topic>Hepatitis C virus</topic><topic>HIV</topic><topic>HIV - immunology</topic><topic>HIV - isolation &amp; purification</topic><topic>HIV Infections - epidemiology</topic><topic>HIV Infections - virology</topic><topic>HIV Seropositivity</topic><topic>Human immunodeficiency virus</topic><topic>Humans</topic><topic>Immune disorders</topic><topic>Immunity</topic><topic>Infections</topic><topic>Italy - epidemiology</topic><topic>Lentivirus</topic><topic>Male</topic><topic>Medical tests</topic><topic>Original Study</topic><topic>Pneumoviridae</topic><topic>Prevalence</topic><topic>Racial differences</topic><topic>Retrospective Studies</topic><topic>Retroviridae</topic><topic>Risk factors</topic><topic>Sex</topic><topic>Sex change surgery</topic><topic>Sex Reassignment Surgery</topic><topic>Sexually transmitted diseases</topic><topic>STD</topic><topic>Surgery</topic><topic>Transgender persons</topic><topic>Transgender Persons - statistics &amp; numerical data</topic><topic>Transsexuality</topic><topic>Viruses</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Luzzati, Roberto</creatorcontrib><creatorcontrib>Zatta, Marta</creatorcontrib><creatorcontrib>Pavan, Nicola</creatorcontrib><creatorcontrib>Serafin, Maurizia</creatorcontrib><creatorcontrib>Maurel, Cristina</creatorcontrib><creatorcontrib>Trombetta, Carlo</creatorcontrib><creatorcontrib>Barbone, Fabio</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Applied Social Sciences Index &amp; Abstracts (ASSIA)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Health and Safety Science Abstracts (Full archive)</collection><collection>Virology and AIDS Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health &amp; Medical Complete (Alumni)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Nursing &amp; Allied Health Premium</collection><collection>MEDLINE - Academic</collection><collection>Immunology Abstracts</collection><collection>Safety Science and Risk</collection><jtitle>Sexually transmitted diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Luzzati, Roberto</au><au>Zatta, Marta</au><au>Pavan, Nicola</au><au>Serafin, Maurizia</au><au>Maurel, Cristina</au><au>Trombetta, Carlo</au><au>Barbone, Fabio</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prevalence of Human Immunodeficiency Virus, Hepatitis B Virus, and Hepatitis C Virus Infections Among Transgender Persons Referred to an Italian Center for Total Sex Reassignment Surgery</atitle><jtitle>Sexually transmitted diseases</jtitle><addtitle>Sex Transm Dis</addtitle><date>2016-07</date><risdate>2016</risdate><volume>43</volume><issue>7</issue><spage>407</spage><epage>411</epage><pages>407-411</pages><issn>0148-5717</issn><eissn>1537-4521</eissn><coden>STRDDM</coden><abstract>INTRODUCTIONThe burden of human immunodeficiency virus (HIV), hepatitis B virus (HBV), and hepatitis C virus (HCV) infections in transgender population is an underestimated issue. We performed a study to evaluate the prevalence of such infections in transgender persons addressed our center for total sex reassignment surgery (SRS). MATERIALS AND METHODSAll transgender persons undergoing SRS from 2000 to 2014 were evaluated retrospectively. Participant characteristics and results of HIV, HBV, and HCV testing were collected. Exact Fisher test, Cochran-Armitage tests for trend and correct prevalence ratios were estimated. RESULTSAmong 498 transgender persons, 243 had confirmed serological data. Of them, 25 were female-to-male and 218 male-to-female (MtF) subjects. The prevalence of HIV, HBV and HCV infections was 0%, 4.0%, and 8.0% in female-to-male, and 12.1%, 4.6%, and 3.7% in MtF. Among MtF, younger age and earlier year of SRS were associated with lower HIV prevalence. From the multivariate model, the mutually adjustment prevalence ratios were 1.9 (95% confidence interval [95% CI], 1.2–3.1) for SRS in 2005–2010 and 3.6 (95% CI, 1.3–9.4) in 2010–2014, as compared with SRS in 2000–2004; and 4.7 (95% CI, 2.4–9.4) for South Americans as compared with others. Among the HCV-positive MtF, 57.1% were also HIV-positive. Regarding HBV, the immunity was 38.5% and, after mutual adjustment, the prevalence ratios were 2.1 (95% CI, 1.3–3.4) for South Americans versus others and 2.2 (95% CI, 1.6–3.1) for year of birth ≥ 1980. DISCUSSIONThe prevalence of HBV and HCV infections among our transgender persons overlaps that reported in the general population, but HCV prevalence was much higher in HIV-infected MtF. The high burden of HIV infection among MtF and its recent incremented prevalence points out that social and medical support should be strongly promoted in such population.</abstract><cop>United States</cop><pub>Lippincott Williams &amp; Wilkins, a business of Wolters Kluwer Health</pub><pmid>27322038</pmid><doi>10.1097/OLQ.0000000000000452</doi><tpages>5</tpages></addata></record>
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source MEDLINE; Applied Social Sciences Index & Abstracts (ASSIA); JSTOR Archive Collection A-Z Listing
subjects Adjustment
Adult
Age differences
Burden
Childbirth & labor
Coinfection
Confidence intervals
Female
Health services
Hepacivirus - immunology
Hepacivirus - isolation & purification
Hepatitis
Hepatitis B
Hepatitis B - epidemiology
Hepatitis B - virology
Hepatitis B virus
Hepatitis B virus - immunology
Hepatitis B virus - isolation & purification
Hepatitis C
Hepatitis C - epidemiology
Hepatitis C - virology
Hepatitis C virus
HIV
HIV - immunology
HIV - isolation & purification
HIV Infections - epidemiology
HIV Infections - virology
HIV Seropositivity
Human immunodeficiency virus
Humans
Immune disorders
Immunity
Infections
Italy - epidemiology
Lentivirus
Male
Medical tests
Original Study
Pneumoviridae
Prevalence
Racial differences
Retrospective Studies
Retroviridae
Risk factors
Sex
Sex change surgery
Sex Reassignment Surgery
Sexually transmitted diseases
STD
Surgery
Transgender persons
Transgender Persons - statistics & numerical data
Transsexuality
Viruses
title Prevalence of Human Immunodeficiency Virus, Hepatitis B Virus, and Hepatitis C Virus Infections Among Transgender Persons Referred to an Italian Center for Total Sex Reassignment Surgery
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