Prevalence of Human Immunodeficiency Virus, Hepatitis B Virus, and Hepatitis C Virus Infections Among Transgender Persons Referred to an Italian Center for Total Sex Reassignment Surgery
INTRODUCTIONThe burden of human immunodeficiency virus (HIV), hepatitis B virus (HBV), and hepatitis C virus (HCV) infections in transgender population is an underestimated issue. We performed a study to evaluate the prevalence of such infections in transgender persons addressed our center for total...
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description | INTRODUCTIONThe burden of human immunodeficiency virus (HIV), hepatitis B virus (HBV), and hepatitis C virus (HCV) infections in transgender population is an underestimated issue. We performed a study to evaluate the prevalence of such infections in transgender persons addressed our center for total sex reassignment surgery (SRS).
MATERIALS AND METHODSAll transgender persons undergoing SRS from 2000 to 2014 were evaluated retrospectively. Participant characteristics and results of HIV, HBV, and HCV testing were collected. Exact Fisher test, Cochran-Armitage tests for trend and correct prevalence ratios were estimated.
RESULTSAmong 498 transgender persons, 243 had confirmed serological data. Of them, 25 were female-to-male and 218 male-to-female (MtF) subjects. The prevalence of HIV, HBV and HCV infections was 0%, 4.0%, and 8.0% in female-to-male, and 12.1%, 4.6%, and 3.7% in MtF. Among MtF, younger age and earlier year of SRS were associated with lower HIV prevalence. From the multivariate model, the mutually adjustment prevalence ratios were 1.9 (95% confidence interval [95% CI], 1.2–3.1) for SRS in 2005–2010 and 3.6 (95% CI, 1.3–9.4) in 2010–2014, as compared with SRS in 2000–2004; and 4.7 (95% CI, 2.4–9.4) for South Americans as compared with others. Among the HCV-positive MtF, 57.1% were also HIV-positive. Regarding HBV, the immunity was 38.5% and, after mutual adjustment, the prevalence ratios were 2.1 (95% CI, 1.3–3.4) for South Americans versus others and 2.2 (95% CI, 1.6–3.1) for year of birth ≥ 1980.
DISCUSSIONThe prevalence of HBV and HCV infections among our transgender persons overlaps that reported in the general population, but HCV prevalence was much higher in HIV-infected MtF. The high burden of HIV infection among MtF and its recent incremented prevalence points out that social and medical support should be strongly promoted in such population. |
doi_str_mv | 10.1097/OLQ.0000000000000452 |
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MATERIALS AND METHODSAll transgender persons undergoing SRS from 2000 to 2014 were evaluated retrospectively. Participant characteristics and results of HIV, HBV, and HCV testing were collected. Exact Fisher test, Cochran-Armitage tests for trend and correct prevalence ratios were estimated.
RESULTSAmong 498 transgender persons, 243 had confirmed serological data. Of them, 25 were female-to-male and 218 male-to-female (MtF) subjects. The prevalence of HIV, HBV and HCV infections was 0%, 4.0%, and 8.0% in female-to-male, and 12.1%, 4.6%, and 3.7% in MtF. Among MtF, younger age and earlier year of SRS were associated with lower HIV prevalence. From the multivariate model, the mutually adjustment prevalence ratios were 1.9 (95% confidence interval [95% CI], 1.2–3.1) for SRS in 2005–2010 and 3.6 (95% CI, 1.3–9.4) in 2010–2014, as compared with SRS in 2000–2004; and 4.7 (95% CI, 2.4–9.4) for South Americans as compared with others. Among the HCV-positive MtF, 57.1% were also HIV-positive. Regarding HBV, the immunity was 38.5% and, after mutual adjustment, the prevalence ratios were 2.1 (95% CI, 1.3–3.4) for South Americans versus others and 2.2 (95% CI, 1.6–3.1) for year of birth ≥ 1980.
DISCUSSIONThe prevalence of HBV and HCV infections among our transgender persons overlaps that reported in the general population, but HCV prevalence was much higher in HIV-infected MtF. The high burden of HIV infection among MtF and its recent incremented prevalence points out that social and medical support should be strongly promoted in such population.</description><identifier>ISSN: 0148-5717</identifier><identifier>EISSN: 1537-4521</identifier><identifier>DOI: 10.1097/OLQ.0000000000000452</identifier><identifier>PMID: 27322038</identifier><identifier>CODEN: STRDDM</identifier><language>eng</language><publisher>United States: Lippincott Williams & Wilkins, a business of Wolters Kluwer Health</publisher><subject>Adjustment ; Adult ; Age differences ; Burden ; Childbirth & labor ; Coinfection ; Confidence intervals ; Female ; Health services ; Hepacivirus - immunology ; Hepacivirus - isolation & purification ; Hepatitis ; Hepatitis B ; Hepatitis B - epidemiology ; Hepatitis B - virology ; Hepatitis B virus ; Hepatitis B virus - immunology ; Hepatitis B virus - isolation & purification ; Hepatitis C ; Hepatitis C - epidemiology ; Hepatitis C - virology ; Hepatitis C virus ; HIV ; HIV - immunology ; HIV - isolation & purification ; HIV Infections - epidemiology ; HIV Infections - virology ; HIV Seropositivity ; Human immunodeficiency virus ; Humans ; Immune disorders ; Immunity ; Infections ; Italy - epidemiology ; Lentivirus ; Male ; Medical tests ; Original Study ; Pneumoviridae ; Prevalence ; Racial differences ; Retrospective Studies ; Retroviridae ; Risk factors ; Sex ; Sex change surgery ; Sex Reassignment Surgery ; Sexually transmitted diseases ; STD ; Surgery ; Transgender persons ; Transgender Persons - statistics & numerical data ; Transsexuality ; Viruses</subject><ispartof>Sexually transmitted diseases, 2016-07, Vol.43 (7), p.407-411</ispartof><rights>Copyright © 2016 American Sexually Transmitted Diseases Association</rights><rights>Copyright 2016 American Sexually Transmitted Diseases Association</rights><rights>Copyright Lippincott Williams & Wilkins Jul 2016</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4351-a6a9b3aaa3f131a085281e756f202962f877092e1706362350b00ef9b2d457253</citedby><cites>FETCH-LOGICAL-c4351-a6a9b3aaa3f131a085281e756f202962f877092e1706362350b00ef9b2d457253</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/48512068$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/48512068$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>314,780,784,803,27923,27924,30998,58016,58249</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27322038$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Luzzati, Roberto</creatorcontrib><creatorcontrib>Zatta, Marta</creatorcontrib><creatorcontrib>Pavan, Nicola</creatorcontrib><creatorcontrib>Serafin, Maurizia</creatorcontrib><creatorcontrib>Maurel, Cristina</creatorcontrib><creatorcontrib>Trombetta, Carlo</creatorcontrib><creatorcontrib>Barbone, Fabio</creatorcontrib><title>Prevalence of Human Immunodeficiency Virus, Hepatitis B Virus, and Hepatitis C Virus Infections Among Transgender Persons Referred to an Italian Center for Total Sex Reassignment Surgery</title><title>Sexually transmitted diseases</title><addtitle>Sex Transm Dis</addtitle><description>INTRODUCTIONThe burden of human immunodeficiency virus (HIV), hepatitis B virus (HBV), and hepatitis C virus (HCV) infections in transgender population is an underestimated issue. We performed a study to evaluate the prevalence of such infections in transgender persons addressed our center for total sex reassignment surgery (SRS).
MATERIALS AND METHODSAll transgender persons undergoing SRS from 2000 to 2014 were evaluated retrospectively. Participant characteristics and results of HIV, HBV, and HCV testing were collected. Exact Fisher test, Cochran-Armitage tests for trend and correct prevalence ratios were estimated.
RESULTSAmong 498 transgender persons, 243 had confirmed serological data. Of them, 25 were female-to-male and 218 male-to-female (MtF) subjects. The prevalence of HIV, HBV and HCV infections was 0%, 4.0%, and 8.0% in female-to-male, and 12.1%, 4.6%, and 3.7% in MtF. Among MtF, younger age and earlier year of SRS were associated with lower HIV prevalence. From the multivariate model, the mutually adjustment prevalence ratios were 1.9 (95% confidence interval [95% CI], 1.2–3.1) for SRS in 2005–2010 and 3.6 (95% CI, 1.3–9.4) in 2010–2014, as compared with SRS in 2000–2004; and 4.7 (95% CI, 2.4–9.4) for South Americans as compared with others. Among the HCV-positive MtF, 57.1% were also HIV-positive. Regarding HBV, the immunity was 38.5% and, after mutual adjustment, the prevalence ratios were 2.1 (95% CI, 1.3–3.4) for South Americans versus others and 2.2 (95% CI, 1.6–3.1) for year of birth ≥ 1980.
DISCUSSIONThe prevalence of HBV and HCV infections among our transgender persons overlaps that reported in the general population, but HCV prevalence was much higher in HIV-infected MtF. The high burden of HIV infection among MtF and its recent incremented prevalence points out that social and medical support should be strongly promoted in such population.</description><subject>Adjustment</subject><subject>Adult</subject><subject>Age differences</subject><subject>Burden</subject><subject>Childbirth & labor</subject><subject>Coinfection</subject><subject>Confidence intervals</subject><subject>Female</subject><subject>Health services</subject><subject>Hepacivirus - immunology</subject><subject>Hepacivirus - isolation & purification</subject><subject>Hepatitis</subject><subject>Hepatitis B</subject><subject>Hepatitis B - epidemiology</subject><subject>Hepatitis B - virology</subject><subject>Hepatitis B virus</subject><subject>Hepatitis B virus - immunology</subject><subject>Hepatitis B virus - isolation & purification</subject><subject>Hepatitis C</subject><subject>Hepatitis C - epidemiology</subject><subject>Hepatitis C - virology</subject><subject>Hepatitis C virus</subject><subject>HIV</subject><subject>HIV - immunology</subject><subject>HIV - isolation & purification</subject><subject>HIV Infections - epidemiology</subject><subject>HIV Infections - virology</subject><subject>HIV Seropositivity</subject><subject>Human immunodeficiency virus</subject><subject>Humans</subject><subject>Immune disorders</subject><subject>Immunity</subject><subject>Infections</subject><subject>Italy - epidemiology</subject><subject>Lentivirus</subject><subject>Male</subject><subject>Medical tests</subject><subject>Original Study</subject><subject>Pneumoviridae</subject><subject>Prevalence</subject><subject>Racial differences</subject><subject>Retrospective Studies</subject><subject>Retroviridae</subject><subject>Risk factors</subject><subject>Sex</subject><subject>Sex change surgery</subject><subject>Sex Reassignment Surgery</subject><subject>Sexually transmitted diseases</subject><subject>STD</subject><subject>Surgery</subject><subject>Transgender persons</subject><subject>Transgender Persons - statistics & numerical data</subject><subject>Transsexuality</subject><subject>Viruses</subject><issn>0148-5717</issn><issn>1537-4521</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>7QJ</sourceid><recordid>eNqFUk1v1DAQtRCILoV_AMgSFw5N8UccO8eyAnalldrShWvkTcZbL4m9tRPK_jV-XR22X-oFX8bz5r1nzXgQekvJMSWl_HS6OD8mj08u2DM0oYLLLF3pczQhNFeZkFQeoFcxbsiYE_oSHTDJGSNcTdDfswC_dQuuBuwNng2ddnjedYPzDRhb21TZ4Z82DPEIz2Cre9vbiD_fQdo1j-DpHsZzZ6DurXcRn3TerfEyaBfX4BoI-AxCHCvfwUAI0ODe4_HRXrc2xSm4PrGMD3jpE4Yv4E_i6hjt2nWpiC-GsIawe41eGN1GeHMbD9GPr1-W01m2OP02n54ssjrngma60OWKa625oZxqogRTFKQoDCOsLJhRUpKSAZWk4AXjgqwIAVOuWJMLyQQ_RB_3vtvgrwaIfdXZWEPbagd-iBVVRElGaJL_lypLVZacljxRPzyhbvwQXGpkZJVcckJHVr5n1cHHGMBU22A7HXYVJdW4BlVag-rpGiTZ-1vzYdVBcy-6-_cH32vfpmnHX-1wDaG6BN32l__8ZBpelroqiExZNkI0yd7tZZvY-3BvmytBGSkUvwGbbMY0</recordid><startdate>201607</startdate><enddate>201607</enddate><creator>Luzzati, Roberto</creator><creator>Zatta, Marta</creator><creator>Pavan, Nicola</creator><creator>Serafin, Maurizia</creator><creator>Maurel, Cristina</creator><creator>Trombetta, Carlo</creator><creator>Barbone, Fabio</creator><general>Lippincott Williams & Wilkins, a business of Wolters Kluwer Health</general><general>Copyright American Sexually Transmitted Diseases Association</general><general>Lippincott Williams & Wilkins Ovid Technologies</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QJ</scope><scope>7QL</scope><scope>7T2</scope><scope>7U9</scope><scope>C1K</scope><scope>H94</scope><scope>K9.</scope><scope>M7N</scope><scope>NAPCQ</scope><scope>7X8</scope><scope>7T5</scope><scope>7U2</scope></search><sort><creationdate>201607</creationdate><title>Prevalence of Human Immunodeficiency Virus, Hepatitis B Virus, and Hepatitis C Virus Infections Among Transgender Persons Referred to an Italian Center for Total Sex Reassignment Surgery</title><author>Luzzati, Roberto ; Zatta, Marta ; Pavan, Nicola ; Serafin, Maurizia ; Maurel, Cristina ; Trombetta, Carlo ; Barbone, Fabio</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4351-a6a9b3aaa3f131a085281e756f202962f877092e1706362350b00ef9b2d457253</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Adjustment</topic><topic>Adult</topic><topic>Age differences</topic><topic>Burden</topic><topic>Childbirth & labor</topic><topic>Coinfection</topic><topic>Confidence intervals</topic><topic>Female</topic><topic>Health services</topic><topic>Hepacivirus - immunology</topic><topic>Hepacivirus - isolation & purification</topic><topic>Hepatitis</topic><topic>Hepatitis B</topic><topic>Hepatitis B - epidemiology</topic><topic>Hepatitis B - virology</topic><topic>Hepatitis B virus</topic><topic>Hepatitis B virus - immunology</topic><topic>Hepatitis B virus - isolation & purification</topic><topic>Hepatitis C</topic><topic>Hepatitis C - epidemiology</topic><topic>Hepatitis C - virology</topic><topic>Hepatitis C virus</topic><topic>HIV</topic><topic>HIV - immunology</topic><topic>HIV - isolation & purification</topic><topic>HIV Infections - epidemiology</topic><topic>HIV Infections - virology</topic><topic>HIV Seropositivity</topic><topic>Human immunodeficiency virus</topic><topic>Humans</topic><topic>Immune disorders</topic><topic>Immunity</topic><topic>Infections</topic><topic>Italy - epidemiology</topic><topic>Lentivirus</topic><topic>Male</topic><topic>Medical tests</topic><topic>Original Study</topic><topic>Pneumoviridae</topic><topic>Prevalence</topic><topic>Racial differences</topic><topic>Retrospective Studies</topic><topic>Retroviridae</topic><topic>Risk factors</topic><topic>Sex</topic><topic>Sex change surgery</topic><topic>Sex Reassignment Surgery</topic><topic>Sexually transmitted diseases</topic><topic>STD</topic><topic>Surgery</topic><topic>Transgender persons</topic><topic>Transgender Persons - statistics & numerical data</topic><topic>Transsexuality</topic><topic>Viruses</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Luzzati, Roberto</creatorcontrib><creatorcontrib>Zatta, Marta</creatorcontrib><creatorcontrib>Pavan, Nicola</creatorcontrib><creatorcontrib>Serafin, Maurizia</creatorcontrib><creatorcontrib>Maurel, Cristina</creatorcontrib><creatorcontrib>Trombetta, Carlo</creatorcontrib><creatorcontrib>Barbone, Fabio</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Applied Social Sciences Index & Abstracts (ASSIA)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Health and Safety Science Abstracts (Full archive)</collection><collection>Virology and AIDS Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><collection>Immunology Abstracts</collection><collection>Safety Science and Risk</collection><jtitle>Sexually transmitted diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Luzzati, Roberto</au><au>Zatta, Marta</au><au>Pavan, Nicola</au><au>Serafin, Maurizia</au><au>Maurel, Cristina</au><au>Trombetta, Carlo</au><au>Barbone, Fabio</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prevalence of Human Immunodeficiency Virus, Hepatitis B Virus, and Hepatitis C Virus Infections Among Transgender Persons Referred to an Italian Center for Total Sex Reassignment Surgery</atitle><jtitle>Sexually transmitted diseases</jtitle><addtitle>Sex Transm Dis</addtitle><date>2016-07</date><risdate>2016</risdate><volume>43</volume><issue>7</issue><spage>407</spage><epage>411</epage><pages>407-411</pages><issn>0148-5717</issn><eissn>1537-4521</eissn><coden>STRDDM</coden><abstract>INTRODUCTIONThe burden of human immunodeficiency virus (HIV), hepatitis B virus (HBV), and hepatitis C virus (HCV) infections in transgender population is an underestimated issue. We performed a study to evaluate the prevalence of such infections in transgender persons addressed our center for total sex reassignment surgery (SRS).
MATERIALS AND METHODSAll transgender persons undergoing SRS from 2000 to 2014 were evaluated retrospectively. Participant characteristics and results of HIV, HBV, and HCV testing were collected. Exact Fisher test, Cochran-Armitage tests for trend and correct prevalence ratios were estimated.
RESULTSAmong 498 transgender persons, 243 had confirmed serological data. Of them, 25 were female-to-male and 218 male-to-female (MtF) subjects. The prevalence of HIV, HBV and HCV infections was 0%, 4.0%, and 8.0% in female-to-male, and 12.1%, 4.6%, and 3.7% in MtF. Among MtF, younger age and earlier year of SRS were associated with lower HIV prevalence. From the multivariate model, the mutually adjustment prevalence ratios were 1.9 (95% confidence interval [95% CI], 1.2–3.1) for SRS in 2005–2010 and 3.6 (95% CI, 1.3–9.4) in 2010–2014, as compared with SRS in 2000–2004; and 4.7 (95% CI, 2.4–9.4) for South Americans as compared with others. Among the HCV-positive MtF, 57.1% were also HIV-positive. Regarding HBV, the immunity was 38.5% and, after mutual adjustment, the prevalence ratios were 2.1 (95% CI, 1.3–3.4) for South Americans versus others and 2.2 (95% CI, 1.6–3.1) for year of birth ≥ 1980.
DISCUSSIONThe prevalence of HBV and HCV infections among our transgender persons overlaps that reported in the general population, but HCV prevalence was much higher in HIV-infected MtF. The high burden of HIV infection among MtF and its recent incremented prevalence points out that social and medical support should be strongly promoted in such population.</abstract><cop>United States</cop><pub>Lippincott Williams & Wilkins, a business of Wolters Kluwer Health</pub><pmid>27322038</pmid><doi>10.1097/OLQ.0000000000000452</doi><tpages>5</tpages></addata></record> |
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subjects | Adjustment Adult Age differences Burden Childbirth & labor Coinfection Confidence intervals Female Health services Hepacivirus - immunology Hepacivirus - isolation & purification Hepatitis Hepatitis B Hepatitis B - epidemiology Hepatitis B - virology Hepatitis B virus Hepatitis B virus - immunology Hepatitis B virus - isolation & purification Hepatitis C Hepatitis C - epidemiology Hepatitis C - virology Hepatitis C virus HIV HIV - immunology HIV - isolation & purification HIV Infections - epidemiology HIV Infections - virology HIV Seropositivity Human immunodeficiency virus Humans Immune disorders Immunity Infections Italy - epidemiology Lentivirus Male Medical tests Original Study Pneumoviridae Prevalence Racial differences Retrospective Studies Retroviridae Risk factors Sex Sex change surgery Sex Reassignment Surgery Sexually transmitted diseases STD Surgery Transgender persons Transgender Persons - statistics & numerical data Transsexuality Viruses |
title | Prevalence of Human Immunodeficiency Virus, Hepatitis B Virus, and Hepatitis C Virus Infections Among Transgender Persons Referred to an Italian Center for Total Sex Reassignment Surgery |
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