Electrode array-eluted dexamethasone protects against electrode insertion trauma induced hearing and hair cell losses, damage to neural elements, increases in impedance and fibrosis: A dose response study

We evaluated the effects of dexamethasone base (DXMb) containing electrode arrays in a guinea pig model of cochlear implantation to determine if eluted DXMb could protect the cochlea against electrode insertion trauma (EIT)-induced: 1) loss of hair cells; 2) disruption of neural elements; 3) increas...

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Veröffentlicht in:	Hearing research 2016-07, Vol.337, p.12-24
Hauptverfasser:	Bas, Esperanza, Bohorquez, Jorge, Goncalves, Stefania, Perez, Enrique, Dinh, Christine T., Garnham, Carolyn, Hessler, Roland, Eshraghi, Adrien A., Van De Water, Thomas R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cochlea - physiology Cochlea - surgery Cochlear implantation Cochlear Implantation - adverse effects Cochlear Implantation - methods Dexamethasone - pharmacology Dose-Response Relationship, Drug Electrodes - adverse effects Female Fibrosis - pathology Guinea Pigs Hair cell loss Hair Cells, Auditory - pathology Hearing Hearing loss Increased impedance Insertion trauma Local delivery of dexamethasone Male Neurons - pathology Otoprotection Scala Tympani - physiology Silicones - chemistry Stress, Mechanical
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