Assessing Alzheimer's disease patients' quality of life: Discrepancies between patient and caregiver perspectives
Abstract Introduction Quality of life (QOL) is an important dimension to consider in Alzheimer's disease (AD), but few large-scale studies have analyzed self and caregiver reports of patient QOL. Methods Patient QOL was evaluated in a cohort of 574 AD patients with the QOL-AD scale over 2 years...
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| Veröffentlicht in: | Alzheimer's & dementia 2016-04, Vol.12 (4), p.427-437 |
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| creator | Andrieu, Sandrine Coley, Nicola Rolland, Yves Cantet, Christelle Arnaud, Catherine Guyonnet, Sophie Nourhashemi, Fati Grand, Alain Vellas, Bruno |
| description | Abstract Introduction Quality of life (QOL) is an important dimension to consider in Alzheimer's disease (AD), but few large-scale studies have analyzed self and caregiver reports of patient QOL. Methods Patient QOL was evaluated in a cohort of 574 AD patients with the QOL-AD scale over 2 years. Results Caregiver reports of patient QOL were lower at baseline than self reports. Older patient age was associated with overestimation of QOL by caregivers, whereas neuropsychiatric inventory score and caregiver burden were associated with underestimation. Activities of daily living limitation, depressive symptoms, and caregiver burden were systematically associated with poorer QOL, whereas caregiver relationship and apathy were associated with poorer QOL only for self reports or caregiver reports, respectively. Cognitive function and professional care were not associated with QOL. Self-rated patient QOL did not change over time, whereas disease severity markers and caregiver-rated patient QOL declined. Discussion It is important to assess both self and caregiver ratings when assessing patient QOL. |
| doi_str_mv | 10.1016/j.jalz.2015.09.003 |
| format | Article |
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Methods Patient QOL was evaluated in a cohort of 574 AD patients with the QOL-AD scale over 2 years. Results Caregiver reports of patient QOL were lower at baseline than self reports. Older patient age was associated with overestimation of QOL by caregivers, whereas neuropsychiatric inventory score and caregiver burden were associated with underestimation. Activities of daily living limitation, depressive symptoms, and caregiver burden were systematically associated with poorer QOL, whereas caregiver relationship and apathy were associated with poorer QOL only for self reports or caregiver reports, respectively. Cognitive function and professional care were not associated with QOL. Self-rated patient QOL did not change over time, whereas disease severity markers and caregiver-rated patient QOL declined. Discussion It is important to assess both self and caregiver ratings when assessing patient QOL.</description><identifier>ISSN: 1552-5260</identifier><identifier>EISSN: 1552-5279</identifier><identifier>DOI: 10.1016/j.jalz.2015.09.003</identifier><identifier>PMID: 26602086</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Age Factors ; Aged ; Aged, 80 and over ; Aging - psychology ; Alzheimer Disease - psychology ; Alzheimer's disease ; Caregivers ; Caregivers - psychology ; Cost of Illness ; Disease Progression ; Female ; Follow-Up Studies ; Humans ; Longitudinal ; Longitudinal Studies ; Male ; Neurology ; Proxy report ; Psychological Tests ; QOL-AD ; Quality of life ; Quality of Life - psychology ; Self Report ; Severity of Illness Index ; Time Factors</subject><ispartof>Alzheimer's & dementia, 2016-04, Vol.12 (4), p.427-437</ispartof><rights>The Alzheimer's Association</rights><rights>2016 The Alzheimer's Association</rights><rights>Copyright © 2016 The Alzheimer's Association. Published by Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5683-cb26890abc5e7c090e726998102b3636a748543189fbc56f8c35c08e3e82abff3</citedby><cites>FETCH-LOGICAL-c5683-cb26890abc5e7c090e726998102b3636a748543189fbc56f8c35c08e3e82abff3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1016%2Fj.jalz.2015.09.003$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1016%2Fj.jalz.2015.09.003$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26602086$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Andrieu, Sandrine</creatorcontrib><creatorcontrib>Coley, Nicola</creatorcontrib><creatorcontrib>Rolland, Yves</creatorcontrib><creatorcontrib>Cantet, Christelle</creatorcontrib><creatorcontrib>Arnaud, Catherine</creatorcontrib><creatorcontrib>Guyonnet, Sophie</creatorcontrib><creatorcontrib>Nourhashemi, Fati</creatorcontrib><creatorcontrib>Grand, Alain</creatorcontrib><creatorcontrib>Vellas, Bruno</creatorcontrib><creatorcontrib>PLASA group</creatorcontrib><title>Assessing Alzheimer's disease patients' quality of life: Discrepancies between patient and caregiver perspectives</title><title>Alzheimer's & dementia</title><addtitle>Alzheimers Dement</addtitle><description>Abstract Introduction Quality of life (QOL) is an important dimension to consider in Alzheimer's disease (AD), but few large-scale studies have analyzed self and caregiver reports of patient QOL. Methods Patient QOL was evaluated in a cohort of 574 AD patients with the QOL-AD scale over 2 years. Results Caregiver reports of patient QOL were lower at baseline than self reports. Older patient age was associated with overestimation of QOL by caregivers, whereas neuropsychiatric inventory score and caregiver burden were associated with underestimation. Activities of daily living limitation, depressive symptoms, and caregiver burden were systematically associated with poorer QOL, whereas caregiver relationship and apathy were associated with poorer QOL only for self reports or caregiver reports, respectively. Cognitive function and professional care were not associated with QOL. Self-rated patient QOL did not change over time, whereas disease severity markers and caregiver-rated patient QOL declined. Discussion It is important to assess both self and caregiver ratings when assessing patient QOL.</description><subject>Age Factors</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Aging - psychology</subject><subject>Alzheimer Disease - psychology</subject><subject>Alzheimer's disease</subject><subject>Caregivers</subject><subject>Caregivers - psychology</subject><subject>Cost of Illness</subject><subject>Disease Progression</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Humans</subject><subject>Longitudinal</subject><subject>Longitudinal Studies</subject><subject>Male</subject><subject>Neurology</subject><subject>Proxy report</subject><subject>Psychological Tests</subject><subject>QOL-AD</subject><subject>Quality of life</subject><subject>Quality of Life - psychology</subject><subject>Self Report</subject><subject>Severity of Illness Index</subject><subject>Time Factors</subject><issn>1552-5260</issn><issn>1552-5279</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkk1v1DAQhiMEoqXwBzgg38plw9jZODZClaLyWa3EAbhwsRxnUhyySdaTtNr-ehy27YEDcPGX3vcda55JkuccUg5cvmrT1nY3qQCep6BTgOxBcszzXKxyUeiH92cJR8kTohZgDYrnj5MjISUIUPI42ZVESOT7S1Z2Nz_QbzGcEqs9oSVko5089hOdst1sOz_t2dCwzjf4mr315AKOtnceiVU4XSP2dwZm-5o5G_DSX2FgIwYa0U3xQk-TR43tCJ_d7ifJt_fvvp5_XG0-f_h0Xm5WLpcqW7lKSKXBVi7HwoEGLITUWnEQVSYzaYu1ytcZV7qJEtkol-UOFGaohK2aJjtJXh5yxzDsZqTJbOOPsetsj8NMhitQBVc5qH9LC5VpDsVaRqk4SF0YiAI2Zgx-a8PecDALFdOahYpZqBjQJlKJphe3-XO1xfrecochCsqD4Np3uP-PSFNuvl9cxGV5i835XeTNIQNjU688BkORTO-w9iG23tSD__sfz_6wu8733tnuJ-6R2mEOfcRluCFhwHxZZmsZrVhe6DhY2S_o58c-</recordid><startdate>201604</startdate><enddate>201604</enddate><creator>Andrieu, Sandrine</creator><creator>Coley, Nicola</creator><creator>Rolland, Yves</creator><creator>Cantet, Christelle</creator><creator>Arnaud, Catherine</creator><creator>Guyonnet, Sophie</creator><creator>Nourhashemi, Fati</creator><creator>Grand, Alain</creator><creator>Vellas, Bruno</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7TK</scope></search><sort><creationdate>201604</creationdate><title>Assessing Alzheimer's disease patients' quality of life: Discrepancies between patient and caregiver perspectives</title><author>Andrieu, Sandrine ; Coley, Nicola ; Rolland, Yves ; Cantet, Christelle ; Arnaud, Catherine ; Guyonnet, Sophie ; Nourhashemi, Fati ; Grand, Alain ; Vellas, Bruno</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5683-cb26890abc5e7c090e726998102b3636a748543189fbc56f8c35c08e3e82abff3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Age Factors</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Aging - psychology</topic><topic>Alzheimer Disease - psychology</topic><topic>Alzheimer's disease</topic><topic>Caregivers</topic><topic>Caregivers - psychology</topic><topic>Cost of Illness</topic><topic>Disease Progression</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Humans</topic><topic>Longitudinal</topic><topic>Longitudinal Studies</topic><topic>Male</topic><topic>Neurology</topic><topic>Proxy report</topic><topic>Psychological Tests</topic><topic>QOL-AD</topic><topic>Quality of life</topic><topic>Quality of Life - psychology</topic><topic>Self Report</topic><topic>Severity of Illness Index</topic><topic>Time Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Andrieu, Sandrine</creatorcontrib><creatorcontrib>Coley, Nicola</creatorcontrib><creatorcontrib>Rolland, Yves</creatorcontrib><creatorcontrib>Cantet, Christelle</creatorcontrib><creatorcontrib>Arnaud, Catherine</creatorcontrib><creatorcontrib>Guyonnet, Sophie</creatorcontrib><creatorcontrib>Nourhashemi, Fati</creatorcontrib><creatorcontrib>Grand, Alain</creatorcontrib><creatorcontrib>Vellas, Bruno</creatorcontrib><creatorcontrib>PLASA group</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Neurosciences Abstracts</collection><jtitle>Alzheimer's & dementia</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Andrieu, Sandrine</au><au>Coley, Nicola</au><au>Rolland, Yves</au><au>Cantet, Christelle</au><au>Arnaud, Catherine</au><au>Guyonnet, Sophie</au><au>Nourhashemi, Fati</au><au>Grand, Alain</au><au>Vellas, Bruno</au><aucorp>PLASA group</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Assessing Alzheimer's disease patients' quality of life: Discrepancies between patient and caregiver perspectives</atitle><jtitle>Alzheimer's & dementia</jtitle><addtitle>Alzheimers Dement</addtitle><date>2016-04</date><risdate>2016</risdate><volume>12</volume><issue>4</issue><spage>427</spage><epage>437</epage><pages>427-437</pages><issn>1552-5260</issn><eissn>1552-5279</eissn><abstract>Abstract Introduction Quality of life (QOL) is an important dimension to consider in Alzheimer's disease (AD), but few large-scale studies have analyzed self and caregiver reports of patient QOL. Methods Patient QOL was evaluated in a cohort of 574 AD patients with the QOL-AD scale over 2 years. Results Caregiver reports of patient QOL were lower at baseline than self reports. Older patient age was associated with overestimation of QOL by caregivers, whereas neuropsychiatric inventory score and caregiver burden were associated with underestimation. Activities of daily living limitation, depressive symptoms, and caregiver burden were systematically associated with poorer QOL, whereas caregiver relationship and apathy were associated with poorer QOL only for self reports or caregiver reports, respectively. Cognitive function and professional care were not associated with QOL. Self-rated patient QOL did not change over time, whereas disease severity markers and caregiver-rated patient QOL declined. 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| subjects | Age Factors Aged Aged, 80 and over Aging - psychology Alzheimer Disease - psychology Alzheimer's disease Caregivers Caregivers - psychology Cost of Illness Disease Progression Female Follow-Up Studies Humans Longitudinal Longitudinal Studies Male Neurology Proxy report Psychological Tests QOL-AD Quality of life Quality of Life - psychology Self Report Severity of Illness Index Time Factors |
| title | Assessing Alzheimer's disease patients' quality of life: Discrepancies between patient and caregiver perspectives |
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