Repeated exposures of the male Sprague Dawley rat reproductive tract to environmental toxicants: Do earlier exposures to di-(2-ethylhexyl)phthalate (DEHP) alter the effects of later exposures?

•Neither in utero nor juvenile (PND21-35) exposure to DEHP affected testis weight or histology.•After in utero DEHP, however, subsequent juvenile exposure did result in significantly reduced testis weight and altered histology.•Both in utero and juvenile exposures resulted in reductions in serum tes...

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Veröffentlicht in:	Reproductive toxicology (Elmsford, N.Y.) N.Y.), 2016-06, Vol.61, p.136-141
Hauptverfasser:	Traore, Kassim, Martinez-Arguelles, Daniel B., Papadopoulos, Vassilios, Chen, Haolin, Zirkin, Barry R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Di-(2-ethylhexyl)phthalate (DEHP) Diethylhexyl Phthalate - toxicity Endocrine disruptors Endocrine Disruptors - toxicity Environmental Pollutants - toxicity Environmental toxicants Female Leydig cells Male Organ Size - drug effects Plasticizers - toxicity Pregnancy Prenatal Exposure Delayed Effects Rats Rats, Sprague-Dawley Testis - drug effects Testis - pathology Testosterone Testosterone - blood
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