Edoxaban vs. warfarin in patients with atrial fibrillation on amiodarone: a subgroup analysis of the ENGAGE AF-TIMI 48 trial

In the ENGAGE AF-TIMI 48 trial, the higher-dose edoxaban (HDE) regimen had a similar incidence of ischaemic stroke compared with warfarin, whereas a higher incidence was observed with the lower-dose regimen (LDE). Amiodarone increases edoxaban plasma levels via P-glycoprotein inhibition. The current...

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Veröffentlicht in:	European heart journal 2015-09, Vol.36 (33), p.2239-2245
Hauptverfasser:	Steffel, J, Giugliano, R P, Braunwald, E, Murphy, S A, Atar, D, Heidbuchel, H, Camm, A J, Antman, E M, Ruff, C T
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Amiodarone - therapeutic use Anti-Arrhythmia Agents - therapeutic use Anticoagulants - therapeutic use Atrial Fibrillation - drug therapy Female Hemorrhage - etiology Humans Male Middle Aged Pyridines - therapeutic use Stroke - etiology Thiazoles - therapeutic use Treatment Outcome Warfarin - therapeutic use
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