Association between androgen receptor expression, Ki-67 and the 21-gene recurrence score in non-metastatic, lymph node-negative, estrogen receptor-positive and HER2-negative breast cancer
BackgroundThe mechanisms underlying the favourable prognosis of androgen receptor (AR) expression in breast cancer are unknown.MethodsThe associations between the 21-gene recurrence score (RS), AR, grade, mitotic score, Ki-67 and estrogen receptor (ER) and progesterone receptor (PgR) expression were...
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| Veröffentlicht in: | Journal of clinical pathology 2015-10, Vol.68 (10), p.839-843 |
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| creator | Vera-Badillo, Francisco E Chang, Martin C Kuruzar, Gordana Ocana, Alberto Templeton, Arnoud J Seruga, Bostjan Goldstein, Robyn Bedard, Philippe L Tannock, Ian F Amir, Eitan |
| description | BackgroundThe mechanisms underlying the favourable prognosis of androgen receptor (AR) expression in breast cancer are unknown.MethodsThe associations between the 21-gene recurrence score (RS), AR, grade, mitotic score, Ki-67 and estrogen receptor (ER) and progesterone receptor (PgR) expression were explored in sequential women with lymph node-negative, ER-positive and HER2-negative breast cancer. Statistical significance of this exploratory study was defined as p3). Median RS was 15 (range 1–53). AR expression showed a minimally significant positive correlation with ER (R=0.37), but no correlation with Ki-67 (R=−0.18). In univariable analysis, AR (p=0.01), ER (p |
| doi_str_mv | 10.1136/jclinpath-2015-203012 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1808717149</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1808717149</sourcerecordid><originalsourceid>FETCH-LOGICAL-b481t-6f7c78cda561c8b572c75b3e177f916e8c0732c67802cacdb80366530f3b97173</originalsourceid><addsrcrecordid>eNqNks1u1DAUhS0EotPCI4AssWExBl87sZ1lVZUWUQkJwTpynJtORokd7KTQZ-PlcJgyEmxgY1vX3z3HP4eQF8DfAEj1du-G3k923jHBocyD5CAekQ0UWrACCvWYbDgXwCpdqBNymtKec5Aa5FNyIhTXqlJ6Q36cpxRcb-c-eNrg_A3RU-vbGG7zIqLDaQ6R4vcpYkoZ2tIPPVN6Zei8Q5odMokrusSI3iFNLkSkvac-eDbibNOc9d2WDvfjtMvVFpnH21y7wy3FNP9pxqaQ-nXvl8f15SdxpGkTMatRZ7NPfEaedHZI-PxhPiNf3l1-vrhmNx-v3l-c37CmMDAz1WmnjWttqcCZptTC6bKRCFp3FSg0jmspnNKGC2dd2xgulSol72RTadDyjLw-6E4xfF3yeeuxTw6HwXoMS6rBcJM5KKp_o_n9qxKUlBl99Re6D0v0-SKZMsCLisMqWB4oF0NKEbt6iv1o430NvF6DUB-DUK9BqA9ByH0vH9SXZsT22PX75zPAD0Az7v9T8ydHmMI_</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1781049019</pqid></control><display><type>article</type><title>Association between androgen receptor expression, Ki-67 and the 21-gene recurrence score in non-metastatic, lymph node-negative, estrogen receptor-positive and HER2-negative breast cancer</title><source>MEDLINE</source><source>BMJ Journals - NESLi2</source><source>PubMed Central</source><creator>Vera-Badillo, Francisco E ; Chang, Martin C ; Kuruzar, Gordana ; Ocana, Alberto ; Templeton, Arnoud J ; Seruga, Bostjan ; Goldstein, Robyn ; Bedard, Philippe L ; Tannock, Ian F ; Amir, Eitan</creator><creatorcontrib>Vera-Badillo, Francisco E ; Chang, Martin C ; Kuruzar, Gordana ; Ocana, Alberto ; Templeton, Arnoud J ; Seruga, Bostjan ; Goldstein, Robyn ; Bedard, Philippe L ; Tannock, Ian F ; Amir, Eitan</creatorcontrib><description>BackgroundThe mechanisms underlying the favourable prognosis of androgen receptor (AR) expression in breast cancer are unknown.MethodsThe associations between the 21-gene recurrence score (RS), AR, grade, mitotic score, Ki-67 and estrogen receptor (ER) and progesterone receptor (PgR) expression were explored in sequential women with lymph node-negative, ER-positive and HER2-negative breast cancer. Statistical significance of this exploratory study was defined as p<0.10.ResultsAnalysis comprised 70 women. Most tumours had high AR expression (97% had scores >3). Median RS was 15 (range 1–53). AR expression showed a minimally significant positive correlation with ER (R=0.37), but no correlation with Ki-67 (R=−0.18). In univariable analysis, AR (p=0.01), ER (p<0.001) and PgR (p<0.001) had significant negative associations with RS. Ki-67 (p=0.16), grade (p=0.40) and mitotic score (p=0.23) showed no association with RS. Multivariable analysis showed similar associations.ConclusionsAR is associated with lower RS, but not with Ki-67.</description><identifier>ISSN: 0021-9746</identifier><identifier>EISSN: 1472-4146</identifier><identifier>DOI: 10.1136/jclinpath-2015-203012</identifier><identifier>PMID: 26076967</identifier><identifier>CODEN: JCPAAK</identifier><language>eng</language><publisher>England: BMJ Publishing Group LTD</publisher><subject>Adult ; Aged ; Biomarkers, Tumor - analysis ; Biomarkers, Tumor - genetics ; Breast cancer ; Breast Neoplasms - chemistry ; Breast Neoplasms - diagnosis ; Breast Neoplasms - genetics ; Breast Neoplasms - pathology ; Cell cycle ; Cell Proliferation ; Cloning ; Estrogens ; Female ; Gene expression ; Gene Expression Profiling - methods ; Humans ; Immunohistochemistry ; Ki-67 Antigen - analysis ; Linear Models ; Lymphatic system ; Medical prognosis ; Metastasis ; Middle Aged ; Mitotic Index ; Multivariate Analysis ; Neoplasm Grading ; Neoplasm Recurrence, Local - chemistry ; Neoplasm Recurrence, Local - genetics ; Neoplasm Recurrence, Local - pathology ; Predictive Value of Tests ; Receptor, ErbB-2 - analysis ; Receptors, Androgen - analysis ; Receptors, Estrogen - analysis ; Regression analysis ; Risk Factors ; Studies ; Tumors</subject><ispartof>Journal of clinical pathology, 2015-10, Vol.68 (10), p.839-843</ispartof><rights>Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions</rights><rights>Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.</rights><rights>Copyright: 2015 Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b481t-6f7c78cda561c8b572c75b3e177f916e8c0732c67802cacdb80366530f3b97173</citedby><cites>FETCH-LOGICAL-b481t-6f7c78cda561c8b572c75b3e177f916e8c0732c67802cacdb80366530f3b97173</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://jcp.bmj.com/content/68/10/839.full.pdf$$EPDF$$P50$$Gbmj$$H</linktopdf><linktohtml>$$Uhttps://jcp.bmj.com/content/68/10/839.full$$EHTML$$P50$$Gbmj$$H</linktohtml><link.rule.ids>114,115,314,780,784,3196,23571,27924,27925,77472,77503</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26076967$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Vera-Badillo, Francisco E</creatorcontrib><creatorcontrib>Chang, Martin C</creatorcontrib><creatorcontrib>Kuruzar, Gordana</creatorcontrib><creatorcontrib>Ocana, Alberto</creatorcontrib><creatorcontrib>Templeton, Arnoud J</creatorcontrib><creatorcontrib>Seruga, Bostjan</creatorcontrib><creatorcontrib>Goldstein, Robyn</creatorcontrib><creatorcontrib>Bedard, Philippe L</creatorcontrib><creatorcontrib>Tannock, Ian F</creatorcontrib><creatorcontrib>Amir, Eitan</creatorcontrib><title>Association between androgen receptor expression, Ki-67 and the 21-gene recurrence score in non-metastatic, lymph node-negative, estrogen receptor-positive and HER2-negative breast cancer</title><title>Journal of clinical pathology</title><addtitle>J Clin Pathol</addtitle><description>BackgroundThe mechanisms underlying the favourable prognosis of androgen receptor (AR) expression in breast cancer are unknown.MethodsThe associations between the 21-gene recurrence score (RS), AR, grade, mitotic score, Ki-67 and estrogen receptor (ER) and progesterone receptor (PgR) expression were explored in sequential women with lymph node-negative, ER-positive and HER2-negative breast cancer. Statistical significance of this exploratory study was defined as p<0.10.ResultsAnalysis comprised 70 women. Most tumours had high AR expression (97% had scores >3). Median RS was 15 (range 1–53). AR expression showed a minimally significant positive correlation with ER (R=0.37), but no correlation with Ki-67 (R=−0.18). In univariable analysis, AR (p=0.01), ER (p<0.001) and PgR (p<0.001) had significant negative associations with RS. Ki-67 (p=0.16), grade (p=0.40) and mitotic score (p=0.23) showed no association with RS. Multivariable analysis showed similar associations.ConclusionsAR is associated with lower RS, but not with Ki-67.</description><subject>Adult</subject><subject>Aged</subject><subject>Biomarkers, Tumor - analysis</subject><subject>Biomarkers, Tumor - genetics</subject><subject>Breast cancer</subject><subject>Breast Neoplasms - chemistry</subject><subject>Breast Neoplasms - diagnosis</subject><subject>Breast Neoplasms - genetics</subject><subject>Breast Neoplasms - pathology</subject><subject>Cell cycle</subject><subject>Cell Proliferation</subject><subject>Cloning</subject><subject>Estrogens</subject><subject>Female</subject><subject>Gene expression</subject><subject>Gene Expression Profiling - methods</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>Ki-67 Antigen - analysis</subject><subject>Linear Models</subject><subject>Lymphatic system</subject><subject>Medical prognosis</subject><subject>Metastasis</subject><subject>Middle Aged</subject><subject>Mitotic Index</subject><subject>Multivariate Analysis</subject><subject>Neoplasm Grading</subject><subject>Neoplasm Recurrence, Local - chemistry</subject><subject>Neoplasm Recurrence, Local - genetics</subject><subject>Neoplasm Recurrence, Local - pathology</subject><subject>Predictive Value of Tests</subject><subject>Receptor, ErbB-2 - analysis</subject><subject>Receptors, Androgen - analysis</subject><subject>Receptors, Estrogen - analysis</subject><subject>Regression analysis</subject><subject>Risk Factors</subject><subject>Studies</subject><subject>Tumors</subject><issn>0021-9746</issn><issn>1472-4146</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqNks1u1DAUhS0EotPCI4AssWExBl87sZ1lVZUWUQkJwTpynJtORokd7KTQZ-PlcJgyEmxgY1vX3z3HP4eQF8DfAEj1du-G3k923jHBocyD5CAekQ0UWrACCvWYbDgXwCpdqBNymtKec5Aa5FNyIhTXqlJ6Q36cpxRcb-c-eNrg_A3RU-vbGG7zIqLDaQ6R4vcpYkoZ2tIPPVN6Zei8Q5odMokrusSI3iFNLkSkvac-eDbibNOc9d2WDvfjtMvVFpnH21y7wy3FNP9pxqaQ-nXvl8f15SdxpGkTMatRZ7NPfEaedHZI-PxhPiNf3l1-vrhmNx-v3l-c37CmMDAz1WmnjWttqcCZptTC6bKRCFp3FSg0jmspnNKGC2dd2xgulSol72RTadDyjLw-6E4xfF3yeeuxTw6HwXoMS6rBcJM5KKp_o_n9qxKUlBl99Re6D0v0-SKZMsCLisMqWB4oF0NKEbt6iv1o430NvF6DUB-DUK9BqA9ByH0vH9SXZsT22PX75zPAD0Az7v9T8ydHmMI_</recordid><startdate>20151001</startdate><enddate>20151001</enddate><creator>Vera-Badillo, Francisco E</creator><creator>Chang, Martin C</creator><creator>Kuruzar, Gordana</creator><creator>Ocana, Alberto</creator><creator>Templeton, Arnoud J</creator><creator>Seruga, Bostjan</creator><creator>Goldstein, Robyn</creator><creator>Bedard, Philippe L</creator><creator>Tannock, Ian F</creator><creator>Amir, Eitan</creator><general>BMJ Publishing Group LTD</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88I</scope><scope>8AF</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>BTHHO</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7X8</scope><scope>7T5</scope><scope>H94</scope></search><sort><creationdate>20151001</creationdate><title>Association between androgen receptor expression, Ki-67 and the 21-gene recurrence score in non-metastatic, lymph node-negative, estrogen receptor-positive and HER2-negative breast cancer</title><author>Vera-Badillo, Francisco E ; Chang, Martin C ; Kuruzar, Gordana ; Ocana, Alberto ; Templeton, Arnoud J ; Seruga, Bostjan ; Goldstein, Robyn ; Bedard, Philippe L ; Tannock, Ian F ; Amir, Eitan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b481t-6f7c78cda561c8b572c75b3e177f916e8c0732c67802cacdb80366530f3b97173</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Biomarkers, Tumor - analysis</topic><topic>Biomarkers, Tumor - genetics</topic><topic>Breast cancer</topic><topic>Breast Neoplasms - chemistry</topic><topic>Breast Neoplasms - diagnosis</topic><topic>Breast Neoplasms - genetics</topic><topic>Breast Neoplasms - pathology</topic><topic>Cell cycle</topic><topic>Cell Proliferation</topic><topic>Cloning</topic><topic>Estrogens</topic><topic>Female</topic><topic>Gene expression</topic><topic>Gene Expression Profiling - methods</topic><topic>Humans</topic><topic>Immunohistochemistry</topic><topic>Ki-67 Antigen - analysis</topic><topic>Linear Models</topic><topic>Lymphatic system</topic><topic>Medical prognosis</topic><topic>Metastasis</topic><topic>Middle Aged</topic><topic>Mitotic Index</topic><topic>Multivariate Analysis</topic><topic>Neoplasm Grading</topic><topic>Neoplasm Recurrence, Local - chemistry</topic><topic>Neoplasm Recurrence, Local - genetics</topic><topic>Neoplasm Recurrence, Local - pathology</topic><topic>Predictive Value of Tests</topic><topic>Receptor, ErbB-2 - analysis</topic><topic>Receptors, Androgen - analysis</topic><topic>Receptors, Estrogen - analysis</topic><topic>Regression analysis</topic><topic>Risk Factors</topic><topic>Studies</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Vera-Badillo, Francisco E</creatorcontrib><creatorcontrib>Chang, Martin C</creatorcontrib><creatorcontrib>Kuruzar, Gordana</creatorcontrib><creatorcontrib>Ocana, Alberto</creatorcontrib><creatorcontrib>Templeton, Arnoud J</creatorcontrib><creatorcontrib>Seruga, Bostjan</creatorcontrib><creatorcontrib>Goldstein, Robyn</creatorcontrib><creatorcontrib>Bedard, Philippe L</creatorcontrib><creatorcontrib>Tannock, Ian F</creatorcontrib><creatorcontrib>Amir, Eitan</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>ProQuest Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>STEM Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>BMJ Journals</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection (Proquest) (PQ_SDU_P3)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>PML(ProQuest Medical Library)</collection><collection>ProQuest Science Journals</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><jtitle>Journal of clinical pathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Vera-Badillo, Francisco E</au><au>Chang, Martin C</au><au>Kuruzar, Gordana</au><au>Ocana, Alberto</au><au>Templeton, Arnoud J</au><au>Seruga, Bostjan</au><au>Goldstein, Robyn</au><au>Bedard, Philippe L</au><au>Tannock, Ian F</au><au>Amir, Eitan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Association between androgen receptor expression, Ki-67 and the 21-gene recurrence score in non-metastatic, lymph node-negative, estrogen receptor-positive and HER2-negative breast cancer</atitle><jtitle>Journal of clinical pathology</jtitle><addtitle>J Clin Pathol</addtitle><date>2015-10-01</date><risdate>2015</risdate><volume>68</volume><issue>10</issue><spage>839</spage><epage>843</epage><pages>839-843</pages><issn>0021-9746</issn><eissn>1472-4146</eissn><coden>JCPAAK</coden><abstract>BackgroundThe mechanisms underlying the favourable prognosis of androgen receptor (AR) expression in breast cancer are unknown.MethodsThe associations between the 21-gene recurrence score (RS), AR, grade, mitotic score, Ki-67 and estrogen receptor (ER) and progesterone receptor (PgR) expression were explored in sequential women with lymph node-negative, ER-positive and HER2-negative breast cancer. Statistical significance of this exploratory study was defined as p<0.10.ResultsAnalysis comprised 70 women. Most tumours had high AR expression (97% had scores >3). Median RS was 15 (range 1–53). AR expression showed a minimally significant positive correlation with ER (R=0.37), but no correlation with Ki-67 (R=−0.18). In univariable analysis, AR (p=0.01), ER (p<0.001) and PgR (p<0.001) had significant negative associations with RS. Ki-67 (p=0.16), grade (p=0.40) and mitotic score (p=0.23) showed no association with RS. Multivariable analysis showed similar associations.ConclusionsAR is associated with lower RS, but not with Ki-67.</abstract><cop>England</cop><pub>BMJ Publishing Group LTD</pub><pmid>26076967</pmid><doi>10.1136/jclinpath-2015-203012</doi><tpages>5</tpages></addata></record> |
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| subjects | Adult Aged Biomarkers, Tumor - analysis Biomarkers, Tumor - genetics Breast cancer Breast Neoplasms - chemistry Breast Neoplasms - diagnosis Breast Neoplasms - genetics Breast Neoplasms - pathology Cell cycle Cell Proliferation Cloning Estrogens Female Gene expression Gene Expression Profiling - methods Humans Immunohistochemistry Ki-67 Antigen - analysis Linear Models Lymphatic system Medical prognosis Metastasis Middle Aged Mitotic Index Multivariate Analysis Neoplasm Grading Neoplasm Recurrence, Local - chemistry Neoplasm Recurrence, Local - genetics Neoplasm Recurrence, Local - pathology Predictive Value of Tests Receptor, ErbB-2 - analysis Receptors, Androgen - analysis Receptors, Estrogen - analysis Regression analysis Risk Factors Studies Tumors |
| title | Association between androgen receptor expression, Ki-67 and the 21-gene recurrence score in non-metastatic, lymph node-negative, estrogen receptor-positive and HER2-negative breast cancer |
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